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Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT-AF.

Abstract：

BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and death. Data on contemporary treatment patterns and outcomes associated with AF in clinical practice are limited. METHODS/DESIGN:The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation is a multicenter, prospective, ambulatory-based registry of incident and prevalent AF. The registry will be a nationwide collaboration of health care providers, including internists, primary care physicians, cardiologists, and electrophysiologists. Initial target enrollment is approximately 10,000 patients to be recruited from approximately 200 US outpatient practices. Enrolled patients will be observed for ≥2 years. A patient-reported outcomes substudy in ≥1,500 patients will provide serial quality-of-life assessments. The goal is to characterize treatment and outcomes of patients with AF, thereby promoting better quality of AF care and improved patient outcomes. CONCLUSION:The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation will provide insights into "real-world" treatment including rate and rhythm control, stroke prevention, transitions to new therapies, and clinical and patient-centered outcomes among patients with AF in community practice settings (ClinicalTrials.gov NCT01165710).

journal_name

Am Heart J

journal_title

American heart journal

authors

Piccini JP,Fraulo ES,Ansell JE,Fonarow GC,Gersh BJ,Go AS,Hylek EM,Kowey PR,Mahaffey KW,Thomas LE,Kong MH,Lopes RD,Mills RM,Peterson ED

doi

10.1016/j.ahj.2011.07.001

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

606-612.e1

issue

4

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(11)00496-0

journal_volume

162

pub_type

临床试验,杂志文章,多中心研究

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