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Coronary risk factors and the severity of angiographic coronary artery disease in members of high-risk pedigrees.

Abstract：

:Affected members of early coronary pedigrees in Utah are at markedly increased risk for the development of clinical coronary heart disease (CHD). The relationship between the presence of coronary risk factors and the severity of angiographic coronary artery disease (CAD) in 53 members of high-risk Utah pedigrees was examined. Mean angiographic severity scores were higher in familial hypercholesterolemia or familial low high-density lipoprotein cholesterol (HDL-C) pedigrees than in type III hyperlipidemia or familial combined hyperlipidemia pedigrees. One sibling pair with hyperhomocyst(e)inemia had the highest mean angiographic severity scores. Clinical CHD (p less than 0.0001), increasing low-density lipoprotein cholesterol (LDL-C) (p = 0.0107), and decreasing HDL-C (p = 0.0068) were significant predictors of angiographic CAD severity. There appeared to be an interaction between gender and body mass index but not between gender and serum lipids in the prediction of angiographic CAD severity. Results of the present study in members of high-risk Utah pedigrees are consistent with results from other angiographic studies in non-high-risk persons. Of particular interest is the suggested independent predictive value of low HDL-C for angiographic CAD severity in members of high-risk pedigrees.

journal_name

Am Heart J

journal_title

American heart journal

authors

Sharp SD,Williams RR,Hunt SC,Schumacher MC

doi

10.1016/0002-8703(92)90635-9

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

279-85

issue

2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(92)90635-9

journal_volume

123

pub_type

杂志文章

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