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Blood pressure variability and prognosis in uncomplicated mild hypertension.

Abstract：

BACKGROUND:The independent prognostic value of blood pressure (BP) variability in essential hypertension and particularly in uncomplicated mild hypertension is not yet completely clear. We investigated the relationship between BP variability, evaluated by noninvasive monitoring, and cardiovascular outcome in uncomplicated mild hypertension patients. METHODS:The occurrence of fatal and nonfatal cardiovascular events was evaluated in 1088 uncomplicated mild hypertension patients, 626 with low BP variability (SD of daytime systolic BP below the mean of the study population) and 462 with high BP variability (SD of daytime systolic BP above the mean of the study population). RESULTS:During the follow-up (4.74 +/- 2.4 years, range 0.5-9.7 years), the event rates per 100 patient-years in subjects with low and high BP variability were 0.72 and 1.5, respectively. Event-free survival was significantly different between the groups (P = .01). However, after adjustment for other covariates in a Cox multivariate analysis, the adverse prognostic relevance of high BP variability was no longer detectable, whereas age, daytime systolic BP, low-density lipoprotein cholesterol, and smoking habit resulted as independent predictors of cardiovascular events. CONCLUSIONS:In uncomplicated mild hypertension population, BP variability evaluated by noninvasive monitoring is not an independent predictor of outcome.

journal_name

Am Heart J

journal_title

American heart journal

authors

Pierdomenico SD,Lapenna D,Bucci A,Manente BM,Mancini M,Cuccurullo F,Mezzetti A

doi

10.1016/j.ahj.2004.06.029

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

934-8

issue

5

eissn

0002-8703

issn

1097-6744

pii

S000287030400612X

journal_volume

149

pub_type

杂志文章

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