Abstract：
BACKGROUND:Contrast-induced acute kidney injury (CIAKI) is a frequent complication after infusion of contrast media in patients undergoing percutaneous coronary intervention. A wide range of CIAKI rates occurs after intervention between 3% and 30%, depending on the definition. The aim of this study was to identify which methodology was more effective at recognizing patients at high risk for in-hospital and out-of-hospital adverse events. METHODS AND RESULTS:Serum creatinine increases, after contrast agent infusion, were evaluated in 755 consecutive and unselected patients. Incidences of CIAKI diagnosed by 2 common definitions varied from 6.9% (creatinine increase of ≥0.5 mg/dL, CIAKI-0.5) to 15.9% (creatinine increase of ≥25%, CIAKI-25%). Significant differences appeared between the 2 definitions of sensitivity to predict renal failure according to receiver operating characteristic curve analysis (98% for CIAKI-0.5 and 62% for CIAKI-25%), using a cutoff value of postprocedural glomerular filtration rate of 60 mL/min. Both definitions of CIAKI were related to composite adverse events, but CIAKI-0.5 showed a stronger predicting value (odds ratio 2.875 vs 1.802, P = .036). In multivariate linear regression, only CIAKI-0.5 was a predictive variable of death (odds ratio 3.174, 95% CI 1.368-7.361). CONCLUSIONS:An increase in serum creatinine of ≥0.5 mg/dL is more sensitive because it recognizes more selectively those patients with a higher risk of mortality and morbidity. Serum creatinine increases of ≥25% overestimate CIAKI by including many patients without postprocedural relevant deterioration of renal function and affected by a lower risk of adverse events at follow-up.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Budano C,Levis M,D'Amico M,Usmiani T,Fava A,Sbarra P,Burdese M,Segoloni GP,Colombo A,Marra Sdoi
10.1016/j.ahj.2011.02.004subject
Has Abstractpub_date
2011-05-01 00:00:00pages
963-71issue
5eissn
0002-8703issn
1097-6744pii
S0002-8703(11)00156-6journal_volume
161pub_type
杂志文章abstract：:Forty-one patients with acute myocardial infarction and ST segment elevation were studied to determine the relationship between early changes in ST segment elevation, time to peak serum creatine kinase (CK), peak serum CK, left ventricular function, and patency of the infarct-related artery. ST segment elevation decre...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90262-0
更新日期：1986-08-01 00:00:00
abstract：:The occurrence of thrombotic events is central to the course of polycythemia vera. Myocardial, cerebral, peripheral, and pulmonary infarctions are frequent and are consequences of throbmoses in small and medium caliber arteries. Thrombosis in large caliber arteries is a rare event. Thrombosis within the chambers of th...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(80)90667-5
更新日期：1980-10-01 00:00:00
abstract：OBJECTIVES:We sought to determine the relationship of adverse diastolic remodeling (ie, worsening diastolic or persistent restrictive filling) with infarct scar characteristics, and to evaluate its prognostic value after ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Severe diastolic dysfunction (restr...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2016.05.020
更新日期：2016-10-01 00:00:00
abstract：:Thiazides produce an average loss of 2 L of extracellular fluid volume, of which about 300 ml is plasma volume, during the first 48 hours of administration, and this reduction is maintained without further loss for as long as the drug is given. Do thiazides lower blood pressure by volume depletion or by direct vasodil...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90116-3
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Assessment of left ventricular (LV) thrombosis risk after acute myocardial infarction (AMI) is important because of potential embolic sequelae that are reduced by oral anticoagulant agents. The goal of this study was to investigate whether early assessment of LV systolic and diastolic performance with pulsed...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/j.ahj.2004.05.025
更新日期：2004-12-01 00:00:00
abstract：:Right ventricular myocardial infarction has been reported to occur exclusively in association with inferior left ventricular infarction. To determine the frequency of right ventricular myocardial infarction in association with anterior left ventricular myocardial infarction, all hearts with anterior myocardial infarct...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(87)90004-4
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Depressive symptoms in patients with heart failure (HF) are common and might be associated with inflammation. No studies have examined both the cross-sectional and prospective association between inflammation and depressive symptoms in patients with HF with adequate correction for disease severity. The aim o...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2011.03.011
更新日期：2011-06-01 00:00:00
abstract：:The development of a group of calcium channel blockers that prolong the QT interval has raised interest in their possible proarrhythmic potential. In animal experiments lidoflazine has no observed arrhythmogenic potential and no antiarrhythmic potential in a model sensitive to the antiarrhythmic properties of both con...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90628-3
更新日期：1985-02-01 00:00:00
abstract：:The effects of handgrip and supine bicycle exercise on hemodynamics and left ventricular (LV) performance were compared in 25 patients with moderate to severe aortic regurgitation (AR) and normal LV ejection fraction at rest (greater than or equal to 50%) and in 10 control subjects. In both groups, heart rate, systoli...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90355-2
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND:The rise in cardiac troponin I after ST-elevation myocardial infarction treated by primary percutaneous coronary interventions (PCIs) is predictive of infarct size and left ventricular ejection fraction (LVEF). However, the comparative value of C-reactive protein (CRP) and troponin I for infarct size evaluat...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2006.07.016
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Under the hypothesis that the G-308A polymorphism in the promoter region of the tumor necrosis factor alpha gene might increase tumor necrosis factor alpha expression, several investigations have been performed to examine the influence of the -308A allele on the risk of cardiovascular events. The results of ...
journal_title：American heart journal
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ahj.2007.02.031
更新日期：2007-05-01 00:00:00
abstract：:Probucol, a new cholesterol-lowering agent, was administered to ambulatory outpatients representing several classes of hyperlipoproteinemia (HL) for two years without dietary restriction. In 32 patients with Type II HL and 12 with Type IIB HL, statistically significant reduction in mean serum cholesterol levels occurr...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(78)90088-1
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Peak exercise oxygen consumption (peak VO2) is an important discriminator of survival in patients with systolic heart failure and is used to select ambulatory patients for transplantation. The major trials assessing the relationship between peak VO2 and survival have used a variety of low-level exercise prot...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/mhj.2001.117508
更新日期：2001-09-01 00:00:00
abstract：:A prospective study examining the relationship between psychological distress and ventricular ectopy was conducted with 125 post-myocardial infarction patients equipped with a transtelephonic ECG monitor. Subjects were subsequently grouped according to the occurrence (n = 59) or nonoccurrence (n = 65) of ventricular a...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(88)90246-3
更新日期：1988-07-01 00:00:00
abstract：:One hundred four patients (101 men, three women), under 40 years of age, with myocardial infarction (MI), underwent coronary arteriography. Eighty patients had significant obstructive coronary artery disease (CAD) (group 1), 23 had normal coronary arteries (group 2), and one patient had coronary ostial stenosis as a r...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90680-0
更新日期：1986-07-01 00:00:00
abstract：:A study of nonbacterial thrombotic endocarditis has been carried out in a series of 3,404 autopsies performed upon atomic bomb survivors in Hiroshima in the period 1953-1970. The prevalence of the lesion was 2.4 per cent, with a greater frequency among the elderly and among females, and with a significant relationship...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90119-2
更新日期：1975-08-01 00:00:00
abstract：:A counterimmunoelectrophoresis technique for detection of serum myoglobin (Mb) was improved using non-ionic polymer dextran. Precipitin lines were graded according to their strength, which was ascertained by radioimmunoassay data. By this method, serum Mb in concentrations of 500 ng./ml. before stain and of 200 ng./ml...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90084-4
更新日期：1978-08-01 00:00:00
abstract：:This study correlates the anatomic pathologic coronary anatomy found by arteriography in each of three groups of symptomatic patients, all with coronary artery disease, divided according to the magnitude of ST-segment depression after an adequate submaximal treadmill exercise test. Group I consists of 45 patients with...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90080-0
更新日期：1975-03-01 00:00:00
abstract：BACKGROUND:Female sex independently predicts bleeding risk after percutaneous coronary intervention (PCI). Bivalirudin is safer than abciximab plus heparin in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Thus, a greater benefit of bivalirudin in women would be expected. METHODS:We performed a...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2012.12.021
更新日期：2013-04-01 00:00:00
abstract：:The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 +/- 19.2 pg/ml to 107.6 +/- 23.7 pg/ml (...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(88)90159-7
更新日期：1988-10-01 00:00:00
abstract：:A double-blind multicenter study compared oral acebutolol (n = 182) with hydrochlorothiazide (n = 178) in the treatment of mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mm Hg). Both agents produced significant and comparable reductions in systolic, diastolic, and mean arterial blood press...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(86)90153-5
更新日期：1986-02-01 00:00:00
abstract：:We previously reported that single-head SPECT imaging with teboroxime is feasible. However, excessive hepatic uptake in some patients may interfere with image interpretation. This study examined the feasibility of improving image quality by use of a preprocessing masking technique to subtract hepatic activity. A band ...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(92)90079-b
更新日期：1992-12-01 00:00:00
abstract：:We studied 56 right ventricular papillary muscles isolated from cats to determine whether the direct mechanical effects of contrast media are due to their pharmacologic action or to the hyperosmolality caused by them. A 10% solution of Renografin-76 abruptly decreased force 22% below control, then slowly increased it ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90550-7
更新日期：1984-07-01 00:00:00
abstract：:The hemodynamic effects of intravenous and intracoronary prostacyclin (PGI2) were evaluated in anesthetized, open-chest instrumented dogs. Coronary artery and aortic blood flows, aortic and left ventricular (LV) diastolic pressure, and heart rate were measured continuously. With intravenous PGI2 both left anterior des...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(81)90033-8
更新日期：1981-11-01 00:00:00
abstract：:Eighty-seven patients with isolated ventricular septal defect (VSD) operated on in the first 5 years of life, that had a mean interval of 10 months between diagnostic catheterization and surgery, were studied retrospectively. The size of the VSD was correlated with diagnostic catheterization data and comparative analy...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80170-1
更新日期：1977-01-01 00:00:00
abstract：:Abnormal interventricular septal motion is a frequent finding after cardiac surgery. However, the time course and underlying mechanisms are not well understood. Nineteen patients, mean age 54 years (range 20 to 82 years), were studied with intraoperative transesophageal echocardiography at five specific times: with th...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(07)80024-x
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Lowering low-density lipoprotein cholesterol (LDL-C) by statins is a key strategy for secondary prevention of acute coronary syndrome (ACS). However, few studies have examined prehospital statin use and admission LDL-C levels in ACS patients with history of myocardial infarction (MI) or revascularization. Th...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2019.02.019
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Systolic wall motion abnormality (WMA) after acute myocardial infarction (AMI) is a major determinant of outcome; the presence and importance of diastolic WMA after AMI are unknown. We therefore sought to detect diastolic WMA using color kinesis and to assess its relation to neurohormonal activation and its ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2004.11.024
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Randomized trials have established efficacy of clopidogrel in various types of acute coronary syndromes (ACS). The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2009.01.002
更新日期：2009-04-01 00:00:00
abstract：:The aim of this study was to examine the effect of ventricular fibrillation and a subsequent defibrillation shock on ventricular excitability and refractoriness in human beings. We studied 16 consecutive patients with implantable cardioverter-defibrillators undergoing follow-up studies. The pre- and post-shock pacing ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(96)90086-1
更新日期：1996-06-01 00:00:00
