当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Comparative hypotensive effects of acebutolol and hydrochlorothiazide in patients with mild to moderate essential hypertension: a double-blind multicenter evaluation.

Comparative hypotensive effects of acebutolol and hydrochlorothiazide in patients with mild to moderate essential hypertension: a double-blind multicenter evaluation.

Abstract：

:A double-blind multicenter study compared oral acebutolol (n = 182) with hydrochlorothiazide (n = 178) in the treatment of mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mm Hg). Both agents produced significant and comparable reductions in systolic, diastolic, and mean arterial blood pressures of 15.9, 14.9, and 15.3 mm Hg on acebutolol, and 15.2, 13.3, and 11.8 mm Hg on hydrochlorothiazide (p = 0.001). Acebutolol induced a significant reduction in resting heart rate of 9.3 bpm (p = 0.001) from baseline. The mean effective doses of acebutolol and hydrochlorothiazide were 757 and 68 mg, respectively. Significantly fewer patients on acebutolol experienced arrhythmia, anorexia, and flatulence, although an equal number of patients (14) in each group discontinued therapy prematurely due to side effects. More hydrochlorothiazide-treated patients developed abnormalities in the levels of serum glucose, uric acid, blood urea nitrogen (BUN), serum potassium, and chloride. No clinically significant trends in laboratory parameters were seen on acebutolol, although a small number of patients (11 on acebutolol and 3 on hydrochlorothiazide) developed asymptomatic positive antinuclear antibody (ANA) tests of low titer. The data show that acebutolol is as effective as hydrochlorothiazide in the treatment of hypertension, is as well tolerated, and produces fewer biochemical abnormalities.

journal_name

Am Heart J

journal_title

American heart journal

authors

Wahl J,Singh BN,Thoden WR

doi

10.1016/0002-8703(86)90153-5

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

353-62

issue

2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(86)90153-5

journal_volume

111

pub_type

临床试验,杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Twenty-four-hour ambulatory electrocardiography in elderly subjects: prevalence of various arrhythmias and prognostic implications (report from the Bronx Longitudinal Aging Study).

    abstract：:Functional, ambulatory, community-dwelling subjects (n = 423, aged 75 to 85 years) underwent baseline 24-hour ambulatory electrocardiography (ECG) examinations as part of the Bronx Aging Study, a 10-year prospective cohort study designed to identify risk factors and disease markers for cardiovascular, cerebrovascular,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90425-1

    authors： Frishman WH,Heiman M,Karpenos A,Ooi WL,Mitzner A,Goldkorn R,Greenberg S

    更新日期：1996-08-01 00:00:00

  • Costs and effects in therapy for acute coronary syndromes: the case of abciximab in high-risk patients undergoing percutaneous transluminal coronary angioplasty in the EPIC study. Evaluation of 7E3 for the Prevention of Ischemic Complications.

    abstract：:Cost-effectiveness analyses are routinely performed to determine whether the additional cost of a novel therapy is balanced by additional effectiveness. The definitions of costs and effects involve a variety of assumptions, both in general economic terms and with regard to the specific medical setting under considerat...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0002-8703(98)70302-3

    authors： van Hout BA,Bowman L,Zelinger DJ,Simoons ML

    更新日期：1998-04-01 00:00:00

  • Direct pharmacologic and osmolal effects of contrast media on the mechanics of heart muscle isolated from cats.

    abstract：:We studied 56 right ventricular papillary muscles isolated from cats to determine whether the direct mechanical effects of contrast media are due to their pharmacologic action or to the hyperosmolality caused by them. A 10% solution of Renografin-76 abruptly decreased force 22% below control, then slowly increased it ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90550-7

    authors： Chuck LH,Refsum H,Rouleau JL,Mathey D,Sievers RE,Parmley WW

    更新日期：1984-07-01 00:00:00

  • Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.

    abstract：:The effects of lorcainide, a new antiarrhythmic drug, on serum electrolytes and osmolality are described in a series of 33 patients with organic heart disease and complex ventricular arrhythmias treated with lorcainide. In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 2...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90690-2

    authors： Somani P,Temesy-Armos PN,Leighton RF,Goodenday LS,Fraker TD Jr

    更新日期：1984-12-01 00:00:00

  • Time of day and outcomes of nonurgent percutaneous coronary intervention performed during working hours.

    abstract：BACKGROUND:During daytime working hours, outcomes may be worse when percutaneous coronary intervention (PCI) is performed later in the day because of operator fatigue and differences in process of care. METHODS:Using the APPROACH database, we analyzed 2,492 consecutive nonurgent PCI procedures performed during working...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2010.03.010

    authors： Cantor WJ,Strauss BH,Graham MM,Southern DA,Woo K,Tyrrell B,Knudtson M,Ghali WA

    更新日期：2010-06-01 00:00:00

  • Role of calcium-blocking agents in treatment of cardiac arrhythmias related to myocardial ischemia.

    abstract：:Potential antiarrhythmic effects of calcium (slow-channel)-blocking drugs ca be indirect or direct. The indirect effect would affect ischemia-induced arrhythmias by improving myocardial perfusion or decreasing myocardial oxygen consumption. The direct effect would affect the electrical activity of the sinoatrial (SA) ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(82)90476-8

    authors： Surawicz B

    更新日期：1982-04-01 00:00:00

  • The effects of initiation or continuation of statin therapy on cholesterol level and all-cause mortality after the diagnosis of left ventricular systolic dysfunction.

    abstract：BACKGROUND:Statins (3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors) are known to reduce mortality and cardiac events in patients with coronary artery disease who have not progressed to left ventricular systolic dysfunction (LVSD) and/or heart failure (HF). This study investigated the effect of changes in s...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.01.029

    authors： Huan Loh P,Windram JD,Tin L,Reddy P,Velavan P,Rigby AS,Atkin P,Nikitin NP,Clark AL,Cleland JG

    更新日期：2007-04-01 00:00:00

  • Electrophysiologic findings in long-term asymptomatic chagasic individuals.

    abstract：:Under electrophysiologic studies, 44 asymptomatic chagasic individuals were studied. The mean age was 39.9 years, with 26 being male. The surface ECG showed normal tracings in 12 patients, left anterior fascicular block in three, incomplete right bundle branch block in two, and right bundle branch block in 27 (isolate...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90206-5

    authors： Pimenta J,Miranda M,Pereira CB

    更新日期：1983-08-01 00:00:00

  • Rationale and design of the TAILOR-PCI digital study: Transitioning a randomized controlled trial to a digital registry.

    abstract：BACKGROUND:Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention (TAILOR-PCI) is the largest cardiovascular genotype-based randomized pragmatic trial (NCT#01742117) to evaluate the role of genotype-guided selection of oral P2Y12 inhibitor ther...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2020.10.069

    authors： Pereira NL,Avram R,So DY,Iturriaga E,Byrne J,Lennon RJ,Murthy V,Geller N,Goodman SG,Rihal C,Rosenberg Y,Bailey K,Pletcher MJ,Marcus GM,Farkouh ME,Olgin JE

    更新日期：2021-02-01 00:00:00

  • Persistent depressive symptoms lower aspirin adherence after acute coronary syndromes.

    abstract：BACKGROUND:Even mild depressive symptoms during hospitalization are an independent risk factor for mortality after acute coronary syndromes (ACS). The mortality risk is highest for patients whose depressive symptoms persist after ACS. Low adherence to medications that reduce the risk of subsequent cardiac events may be...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.05.014

    authors： Rieckmann N,Kronish IM,Haas D,Gerin W,Chaplin WF,Burg MM,Vorchheimer D,Davidson KW

    更新日期：2006-11-01 00:00:00

  • Transdermal clonidine as an adjunct to nifedipine-GITS therapy in patients with mild-to-moderate hypertension.

    abstract：:Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(93)90707-g

    authors： Houston MC,Hays L

    更新日期：1993-10-01 00:00:00

  • Circulating atrial natriuretic polypeptide in essential hypertension.

    abstract：:To investigate the significance of atrial natriuretic polypeptide (ANP) in essential hypertension, we measured plasma ANP concentrations in 43 subjects with essential hypertension uncomplicated by cardiac or renal failure, in 16 subjects with borderline hypertension, and in 17 normotensive control subjects. Plasma ANP...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90929-x

    authors： Kohno M,Yasunari K,Matsuura T,Murakawa K,Takeda T

    更新日期：1987-05-01 00:00:00

  • Effect of oral combination therapy with mexiletine and quinidine on left and right ventricular function.

    abstract：:Combination therapy with mexiletine (MEX) and quinidine (Q) may be more efficacious than monotherapy with either drug in suppressing ventricular arrhythmias, but its effects on ventricular performance are not known. Thus, right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF) and wall...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(88)90072-5

    authors： Sheldon RS,Duff HJ,Mitchell LB,Wyse DG,Manyari DE

    更新日期：1988-05-01 00:00:00

  • Design and rationale for the Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in non-responders and previously untreatable patients (SOLVE-CRT) trial.

    abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves outcomes, functional capacity and quality of life in patients with heart failure. Despite two decades of experience with CRT, the rate of non-response remains approximately 30%. CRT efficacy is impacted by pacing location, which is anatomically limited in conv...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2019.04.002

    authors： Singh JP,Abraham WT,Auricchio A,Delnoy PP,Gold M,Reddy VY,Sanders P,Lindenfeld J,Rinaldi CA

    更新日期：2019-11-01 00:00:00

  • Temporal trends and patterns of early clopidogrel use across the spectrum of acute coronary syndromes.

    abstract：BACKGROUND:Randomized trials have established efficacy of clopidogrel in various types of acute coronary syndromes (ACS). The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2009.01.002

    authors： Rao RV,Goodman SG,Yan RT,Spencer FA,Fox KA,DeYoung JP,Rose B,Grondin FR,Gallo R,Gore JM,Yan AT,Canadian Global Registry of Acute Coronary Events (GRACE\/GRACE(2)) Investigators.

    更新日期：2009-04-01 00:00:00

  • The natural history of benign and potentially malignant ventricular arrhythmias with special reference to nonsustained ventricular tachycardia.

    abstract：:Ambulatory ECG recordings are routinely used to identify patients at increased risk of sudden cardiac death and to monitor changes in ventricular arrhythmias during antiarrhythmic drug therapy. The arrhythmia frequency established during the initial baseline has previously been reported to change during a second place...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(88)90139-1

    authors： Pratt CM,Francis M,Mahler S,Aogaichi K,Keus P,Young JB

    更新日期：1988-10-01 00:00:00

  • Comparison of propafenone and disopyramide for treatment of chronic ventricular arrhythmias: placebo-controlled, double-blind, randomized crossover study.

    abstract：:In a double blind, placebo-controlled study, the efficacy of propafenone, a new antiarrhythmic drug was compared to that of disopyramide. Sixteen patients with frequent and complex premature ventricular contractions (PVCs) were studied by serial 24-hour ambulatory monitoring, while they were receiving propafenone, 300...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(85)90647-7

    authors： Naccarella F,Bracchetti D,Palmieri M,Cantelli I,Bertaccini P,Ambrosioni E

    更新日期：1985-04-01 00:00:00

  • Heart rate and blood pressure responses during sexual activity in normal males.

    abstract：:In order to properly advise cardiac patients in the regulation of their sexual activity, more basic physiologic information is needed concerning the cardiovascular effects of sexual intercourse. This study examined the effects of the male's position during sexual intercourse on heart rate and blood pressure responses....

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(76)80106-8

    authors： Nemec ED,Mansfield L,Kennedy JW

    更新日期：1976-09-01 00:00:00

  • The effects of cytochrome C on the extent of myocardial infarction and regional function of the ischemic myocardium.

    abstract：:The effects of cytochrome C, an electron carrier in the process of oxidative phosphorylation, on infarct size and regional left ventricular function after a coronary artery occlusion were investigated. Thus, in 30 dogs, 1 minute after left anterior descending coronary artery occlusion, 99mTc-labeled albumin microspher...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90019-6

    authors： Zalewski A,Goldberg S,Krol R,Maroko PR

    更新日期：1987-01-01 00:00:00

  • Restrictive hemodynamic patterns after cardiac transplantation: relationship to histologic signs of rejection.

    abstract：:Hemodynamic and echocardiographic data from 33 consecutive patients undergoing cardiac transplantation were correlated with endomyocardial biopsy results to determine whether reversible restrictive hemodynamics accompany histologic evidence of transplant rejection. During the study period 251 biopsy specimens were obt...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90475-w

    authors： Wilensky RL,Bourdillon PD,O'Donnell JA,Sharp SM,Armstrong WF,Fineberg NS,Himes V,Waller BF

    更新日期：1991-10-01 00:00:00

  • Recent temporal trends for first-time hospitalization for acute myocardial infarction. Treatment patterns and clinical outcome in a large cohort study.

    abstract：BACKGROUND:The objective was to report recent trends in the incidence, adoption of evidence-based treatment, and clinical outcomes for first-time hospitalization for acute myocardial infarction. METHODS:This is a large retrospective population-based cohort study using medical administrative data (International Classif...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2013.08.026

    authors： Ortolani P,Marino M,Melandri G,Guastaroba P,Corzani A,Berti E,Rapezzi C,De Palma R,Branzi A

    更新日期：2013-11-01 00:00:00

  • Tamoxifen is not detrimental to endothelial function in postmenopausal women with breast cancer.

    abstract：BACKGROUND:Tamoxifen has mixed estrogen agonist and antagonist properties in estrogen-regulated tissues. Its effect on the cardiovascular system is not well defined. We carried out a study to investigate the effect of tamoxifen on peripheral vascular endothelial function. METHODS:Three groups of postmenopausal women (...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.117323

    authors： Ong PJ,Linardou H,Graham HA,Savage P,Hayward CS,Coombes RC,Collins P

    更新日期：2001-10-01 00:00:00

  • Perioperative outcomes in reoperative cardiac surgery guided by cardiac multidetector computed tomographic angiography.

    abstract：BACKGROUND:Preoperative evaluation with contrast-enhanced multidetector computed tomographic angiography (MDCTA) is considered an "appropriate" indication based on expert consensus. We aimed to evaluate how the presurgical evaluation with MDCTA impacts the outcomes after reoperative cardiac surgery (RCS). METHODS:We r...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.11.005

    authors： Maluenda G,Goldstein MA,Lemesle G,Weissman G,Weigold G,Landsman MJ,Hill PC,Pita F,Corso PJ,Boyce SW,Pichard AD,Waksman R,Taylor AJ

    更新日期：2010-02-01 00:00:00

  • Early detection of doxorubicin cardiotoxicity: interest of Doppler echocardiographic analysis of left ventricular filling dynamics.

    abstract：:Doxorubicin (Adriamycin) is an effective anticancer agent but its therapeutic value is limited by its myocardial cardiotoxicity. To improve early detection of doxorubicin cardiotoxicity, studies were performed in patients with long-term doxorubicin treatment using pulsed Doppler echocardiography to assess the changes ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90077-x

    authors： Marchandise B,Schroeder E,Bosly A,Doyen C,Weynants P,Kremer R,Pouleur H

    更新日期：1989-07-01 00:00:00

  • Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction.

    abstract：BACKGROUND:We aimed to study the comparative safety and effectiveness of various antithrombotic treatment strategies among older adults with non-ST elevation myocardial infarction (NSTEMI) and atrial fibrillation (AF). METHODS:Using the CRUSADE registry linked to longitudinal Medicare claims data, we examined NSTEMI p...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.01.017

    authors： Fosbol EL,Wang TY,Li S,Piccini JP,Lopes RD,Shah B,Mills RM,Klaskala W,Alexander KP,Thomas L,Roe MT,Peterson ED

    更新日期：2012-04-01 00:00:00

  • Comparison of clinical features of non-Q wave and Q wave myocardial infarction.

    abstract：:The clinical spectrum and outcome of 119 patients with acute non-Q wave myocardial infarction (NQMI) were studied, in comparison with those of 354 patients with acute Q wave myocardial infarction (QMI). The patients with NQMI had a significantly higher incidence of preinfarction angina (73% vs 63%), previous myocardia...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(86)90056-6

    authors： Ogawa H,Hiramori K,Haze K,Saito M,Sumiyoshi T,Fukami K,Goto Y,Ikeda M

    更新日期：1986-03-01 00:00:00

  • Optimized duration of clopidogrel therapy following treatment with the Endeavor zotarolimus-eluting stent in real-world clinical practice (OPTIMIZE) trial: rationale and design of a large-scale, randomized, multicenter study.

    abstract：BACKGROUND:Current recommendations for antithrombotic therapy after drug-eluting stent (DES) implantation include prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel ≥12 months. However, the impact of such a regimen for all patients receiving any DES system remains unclear based on scientific eviden...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2012.09.009

    authors： Feres F,Costa RA,Bhatt DL,Leon MB,Botelho RV,King SB 3rd,de Paula JE,Mangione JA,Salvadori D Jr,Gusmão MO,Castello H Jr,Nicolela E Jr,Perin MA,Devito FS,Marin-Neto JA,Abizaid A

    更新日期：2012-12-01 00:00:00

  • Effects of exercise training on left ventricular volumes and function in patients with nonischemic cardiomyopathy: application of magnetic resonance myocardial tagging.

    abstract：BACKGROUND:Exercise training is now an accepted component of the therapeutic regimen in patients with heart failure and underlying ischemia, but few data are available on the effects of training in patients with nonischemic dilated cardiomyopathy. METHODS:Twenty-four patients (mean age 55 +/- 9 years, mean ejection fr...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1067/mhj.2002.124401

    authors： Myers J,Wagner D,Schertler T,Beer M,Luchinger R,Klein M,Rickli H,Muller P,Mayer K,Schwitter J,Dubach P

    更新日期：2002-10-01 00:00:00

  • Prognostic utility of single-photon emission computed tomography in adult patients with hypertrophic cardiomyopathy.

    abstract：BACKGROUND:Data derived from stress myocardial perfusion imaging (MPI) carry prognostic significance in young patients with hypertrophic cardiomyopathy (HCM), but there are limited data on the utility of stress MPI in patients with HCM who are older. This study examined the prognostic significance of stress MPI in an a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.02.050

    authors： Sorajja P,Chareonthaitawee P,Ommen SR,Miller TD,Hodge DO,Gibbons RJ

    更新日期：2006-02-01 00:00:00

  • Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR).

    abstract：BACKGROUND:Although prior studies have demonstrated disparities in the management and outcomes of women with acute coronary syndrome (ACS), there are limited large-scale contemporary data on gender differences in post-intervention outcomes in this population. METHODS:We analyzed patients according to 2 ACS categories,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.08.012

    authors： Akhter N,Milford-Beland S,Roe MT,Piana RN,Kao J,Shroff A

    更新日期：2009-01-01 00:00:00