Role of calcium-blocking agents in treatment of cardiac arrhythmias related to myocardial ischemia.

Abstract:

:Potential antiarrhythmic effects of calcium (slow-channel)-blocking drugs ca be indirect or direct. The indirect effect would affect ischemia-induced arrhythmias by improving myocardial perfusion or decreasing myocardial oxygen consumption. The direct effect would affect the electrical activity of the sinoatrial (SA) and atrioventricular (AV) nodes and any type of cardiac fibers depolarized to a level at which the slow inward current becomes activated. Although myocardial ischemia could become a setting of slow-channel-dependent conduction or automaticity, or both, there is no conclusive evidence that slow-channel-blocking drugs suppress ischemia-induced ventricular arrhythmias. Thus the principal usefulness of slow-channel-blocking drugs may be expected in the treatment of supraventricular arrhythmias and in the prevention of arrhythmogenic ischemia.

journal_name

Am Heart J

journal_title

American heart journal

authors

Surawicz B

doi

10.1016/0002-8703(82)90476-8

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

698-706

issue

4 Pt 2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(82)90476-8

journal_volume

103

pub_type

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