Abstract:
:We compared the effects of IV digoxin (0.04 mg/kg) and nitroprusside (NP) (1.2 and 1.8 microgram/kg/min) on left ventricular (LV) performance in six preinstrumented conscious dogs with 3 and 6 hours after digoxin administration (serum level, 3.5 +/- 0.6 ng/ml), there were no changes in heart rate, LV systolic (LVSP) and end-diastolic (LVEDP) pressures, LV dimensions, LV dP/dtmax, or percent minor diameter shortening as compared to control values in the resting state, after beta blockade, or during phenylephrine infusion. By contrast, NP produced a significant reduction (p less than 0.05) in LVEDP (16 +/- 3 to 10 +/- 3 mm Hg) at the smaller dose which caused no change in mean aortic pressure. The larger dose of NP further reduced LVEDP and evoked significant (p less than 0.05) decreases in LVSP (124 +/- 5 to 117 +/- 7 mm Hg), mean aortic pressure (85 +/- 3 to 78 +/- 5 mm Hg), and LV end-diastolic dimension (LVEDD) (53.0 +/- 5.5 to 52.0 +/- 5.7 mm), while augmenting LV dp/dtmax (3288 +/- 266 to 3647 +/- 130 mm Hg/sec). Beta blockade with IV propranolol (2.0 mg/kg) prevented the rise in LV dP/dtmax after high-dose NP administration but did not alter the reductions in mean aortic pressure, LVEDP, and LVEDD. This study indicates that NP, but not digitalis, has a favorable effect on LV hemodynamics in the volume-overloaded heart with normal LV systolic contraction and high-output CHF resulting from increased blood volume and reduced LV diastolic compliance. At least part of the apparent improvement in LV performance observed with high-dose NP is sympathetically mediated since it can be attenuated by beta blockade.
journal_name
Am Heart Jjournal_title
American heart journalauthors
O'Rourke RA,Badke FR,Forst Ddoi
10.1016/0002-8703(82)90335-0subject
Has Abstractpub_date
1982-04-01 00:00:00pages
489-97issue
4 Pt 1eissn
0002-8703issn
1097-6744pii
0002-8703(82)90335-0journal_volume
103pub_type
杂志文章abstract::Atherosclerotic coronary artery disease is a serious clinical problem. Clinicians dealing with patients can make a diagnosis of coronary disease in several ways. Unfortunately all too often the diagnosis is made via sudden death or acute myocardial infarction. At other times the diagnosis is made by evaluation of pati...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(92)91039-4
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:To examine sex differences in pain and associated symptoms in patients with exercise-related ischemia, as well as the independence of these findings from other clinical factors. METHODS:Prospective study of 482 women and 425 men (mean age 58 years) undergoing exercise stress testing with myocardial perfusio...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.06.028
更新日期:2006-04-01 00:00:00
abstract::The skeletal muscle of three cases presenting with idiopathic congestive cardiomyopathy has been studied, histologically, histochemically, ultramicroscopically, and electromyographically. In all three there is clinical evidence of skeletal muscle weakness, and in all three, pathologic changes were found in the muscle....
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90467-6
更新日期:1975-12-01 00:00:00
abstract::We developed a new angiographic score of the extent of coronary disease (extent score), which we compared with conventional stenosis and vessel scores that emphasize the severity of stenosis. Scores were determined in 132 patients (29 women, 103 men with a mean age of 55 +/- 10 years) who underwent elective coronary a...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80173-5
更新日期:1990-06-01 00:00:00
abstract::The acute and chronic cellular electrophysiologic actions of ketanserin, a selective blocker of 5-hydroxytriptamine (5-HT2) receptor, were examined in the isolated rabbit ventricular muscle. This work was prompted by the recent observations that small numbers of patients treated with hypertension develop QTc prolongat...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(88)90012-9
更新日期:1988-06-01 00:00:00
abstract::Adenosine infusion is accompanied by increases in coronary blood flow and myocardial blood volume. Myocardial blood volume may produce changes in diastolic left ventricular (LV) performance by increasing myocardial turgor. Diastolic dysfunction may also be the result of myocardial ischemia. The relation between change...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90318-6
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. METHODS:Data were analyzed from 254 patients in the UNITE-HF Bio...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2010.07.033
更新日期:2010-12-01 00:00:00
abstract::Probucol, a new cholesterol-lowering agent, was administered to ambulatory outpatients representing several classes of hyperlipoproteinemia (HL) for two years without dietary restriction. In 32 patients with Type II HL and 12 with Type IIB HL, statistically significant reduction in mean serum cholesterol levels occurr...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(78)90088-1
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:No-reflow after primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) is associated with poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor that might aggravate reperfusion injury. The aim of our study was to assess the relationship be...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.02.019
更新日期:2010-05-01 00:00:00
abstract::Even though congestive heart failure is extremely common, the mechanisms responsible for the clinical manifestations remain a puzzle. The central and autonomic (sympathetic) nervous systems are responsible for a large part of the clinical manifestations. The role of the nervous system in CHF is discussed briefly. It i...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(78)90471-4
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Clinical practice is discrepant regarding routine enlargement of the interatrial communication (IAC) in patients with right-sided atrioventricular valve atresia. We determined the percentage and risk factors of those who develop a restrictive IAC. METHODS:Medical records were reviewed for patients treated f...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.07.037
更新日期:2007-12-01 00:00:00
abstract::Recent research indicates that silent myocardial ischemia may play a role in sudden cardiac death. To what extent treatment can reduce occurrence of silent ischemia remains to be assessed. Three classes of silent ischemia patients are identified: type 1--totally asymptomatic; type 2--post myocardial infarction; and ty...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90673-x
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Clinical outcomes and the effects of oral anticoagulants among patients with acute coronary syndrome (ACS) and either a history of or acute heart failure (HF) are largely unknown. We aimed to assess the relationship between prior HF or acute HF complicating an index ACS event and subsequent clinical outcomes...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2014.12.022
更新日期:2015-04-01 00:00:00
abstract::Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver for excretion. Impaired cholesterol efflux is associated with higher cardiovascular (CV) event ra...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2020.10.052
更新日期:2021-01-01 00:00:00
abstract::Atrial pacing-induced changes in the sum of R-wave amplitude were measured in leads V5, X, Y, and Z at rates of 100 bpm (phase I), 150 bpm (phase II), and immediately after pacing (phase III) in 33 patients undergoing cardiac catheterization for evaluation of chest pain. Seventeen (51%) patients showed evidence of isc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90133-9
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:There is increasing evidence that transplantation of autologous stem cells improves cardiac function after acute myocardial infarction (AMI). For propagation of peripheral blood stem cells (PBSCs), application of granulocyte-colony stimulating factor (G-CSF) has been shown to be feasible, effective, and safe...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/j.ahj.2006.03.012
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Observational studies have shown apparently lower ischemic coronary disease risk in postmenopausal women receiving hormone replacement therapy (HRT). However, several recent studies have shown an increase in ischemic cardiac events when HRT is initiated in postmenopausal women with known coronary artery dise...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2004.10.028
更新日期:2005-09-01 00:00:00
abstract::The rate and form of creatine kinase-MB (CK-MB) enzyme release following reflow to ischemic myocardium has not been specifically examined in man. In this investigation, we examined the combined CK-MB time-activity curves during acute transmural myocardial infarction (AMI) in a group of patients receiving conventional ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90084-4
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Studies document better survival in heart failure patients with decreased left ventricular ejection fraction (EF) and higher body mass index (BMI; kg/m(2)) compared to those with a lower BMI. However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2009.10.026
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Vesnarinone has yielded controversial results on morbidity in patients with congestive heart failure. We tested the hypothesis that vesnarinone may have a beneficial effect on cardiac remodeling and function. METHODS:Thirty-four patients with left ventricular ejection fraction (LVEF) <30% (17 treated with v...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-8703(98)70120-6
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Knowledge of the natural course after an ST-elevation myocardial infarction (STEMI) treated according to guidelines is limited because comprehensive serial magnetic resonance imaging (MRI) of systolic left ventricular function, edema, perfusion, and infarct size after STEMI has not been undertaken. The aim o...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.06.038
更新日期:2007-11-01 00:00:00
abstract::We altered the mechanical activity of the atrial myocardium in open-chest dogs and measured changes in coronary blood flow distribution, using the radioactive microsphere technique. When left and right atrial pressures were decreased to 2 mm Hg by hypovolemia, atrial coronary blood flow fell to values nearly 50% below...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90701-9
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global longitudinal strain (GLS) is a predictor of cardiovascular events including heart failure. I...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2015.02.011
更新日期:2015-05-01 00:00:00
abstract::Asymptomatic atrial fibrillation (AF) is common and may have the same prognostic implications as symptomatic AF. Among patients receiving dual-chamber pacemakers, it is now possible to quantify asymptomatic AF accurately. Most of these episodes are of short duration, often lasting only seconds to minutes and are calle...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.02.016
更新日期:2006-09-01 00:00:00
abstract::Fatal myocardial infarction occurring in a neonate is reported. The patient presented with a clinical picture of cardiogenic shock simulating a hypoplastic left heart syndrome. Etiology of the myocardial infarction is uncertain for the coronary arteries were patent, anatomically and histologically normal, and there wa...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90052-6
更新日期:1975-02-01 00:00:00
abstract::The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90661-2
更新日期:1987-06-01 00:00:00
abstract::Angiographic evidence of coronary dissection after angioplasty is found in 25% to 30% of cases. Although patients are usually asymptomatic, in a small percentage angioplasty-induced coronary dissection results in luminal impairment and ischemic complications. The present study was undertaken to identify factors respon...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(07)80008-1
更新日期:1993-07-01 00:00:00
abstract::To assess the role of oxidative stress in exercise intolerance in patients with heart failure, a symptom-limited exercise test was performed with a bicycle ergometer in 12 patients with heart failure and in 7 members of a healthy control group. Level of plasma malondialdehyde, a marker of lipid peroxidation, at rest w...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70351-5
更新日期:1998-01-01 00:00:00
abstract::Blood platelets play essential roles in normal coagulation and in coronary atherosclerotic disease and its complications. Various antiplatelet therapies, including aspirin, ticlopidine, and dipyridamole, have been developed for use in patients with known coronary artery artery disease to prevent ischemic complications...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(95)90091-8
更新日期:1995-10-01 00:00:00
abstract::In a demographic study, the black Ohio residents were characterized by those born in Ohio and those born in other regions of the United States, and comparisons were made of rates for all deaths (1960-1967) for coronary heart disease (420), endocarditis and myocardial degeneration (421-422), hypertensive cardiovascular...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90329-4
更新日期:1975-09-01 00:00:00