Atrial coronary hyperemia and ischemia in response to variations in atrial pressure in dogs.

Abstract:

:We altered the mechanical activity of the atrial myocardium in open-chest dogs and measured changes in coronary blood flow distribution, using the radioactive microsphere technique. When left and right atrial pressures were decreased to 2 mm Hg by hypovolemia, atrial coronary blood flow fell to values nearly 50% below baseline. Acute left atrial hypertension was induced by creating mitral valvular incompetence. Progressive increases in left atrial pressure from 8 to 12 to 20 mm Hg caused increases in left atrial coronary blood flow from 47 to 54 to 75 ml/100 gm X min (mean values). Severe left atrial hypertension (32 mm Hg) caused a fall in left atrial blood flow to 30 ml/100 gm X min. The P wave in lead II of the ECG widened by a mean value of 18 msec, suggesting ischemic impairment of left atrial depolarization.

journal_name

Am Heart J

journal_title

American heart journal

authors

Neill WA,Sewell DH,Gosalia KP,Kingsley EM,Oxendine JM

doi

10.1016/0002-8703(83)90701-9

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

554-8

issue

3

eissn

0002-8703

issn

1097-6744

pii

0002-8703(83)90701-9

journal_volume

106

pub_type

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