Abstract:
:The effects of lorcainide, a new antiarrhythmic drug, on serum electrolytes and osmolality are described in a series of 33 patients with organic heart disease and complex ventricular arrhythmias treated with lorcainide. In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide. Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide. In all except two patients, serum Na+ returned to normal values within 3 to 12 months of continued lorcainide therapy. Low serum Na+ and hypoosmolality in the absence of volume depletion, clinically manifest edema, and unaltered renal, adrenal, cardiac, or thyroid function suggest that this antiarrhythmic drug produced the syndrome of inappropriate antidiuretic hormone secretion (SIADH). SIADH appeared to be transient and asymptomatic in our patients. One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension. It is concluded that SIADH is an important side effect of lorcainide therapy. We recommend that serum Na+ be carefully monitored in patients started on lorcainide therapy, and extreme caution should be exercised in prescribing diuretics to patients with persistent hyponatremia.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Somani P,Temesy-Armos PN,Leighton RF,Goodenday LS,Fraker TD Jrdoi
10.1016/0002-8703(84)90690-2subject
Has Abstractpub_date
1984-12-01 00:00:00pages
1443-8issue
6eissn
0002-8703issn
1097-6744pii
0002-8703(84)90690-2journal_volume
108pub_type
杂志文章abstract:BACKGROUND:Although the use of clopidogrel in patients "unlikely" to require coronary artery bypass grafting (CABG) is recommended in current guidelines of acute coronary syndrome (ACS) management, an important minority of patients require CABG. We assessed the ability to predict need for CABG from demographics known a...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.12.002
更新日期:2008-05-01 00:00:00
abstract::The hemodynamic effects of dopamine (DPM) and dobutamine (DBM) were compared in 13 patients with acute cardiogenic circulatory collapse. All patients presented with acute pump failure and inadequate systemic perfusion, and most were hypotensive. Nine patients had an acute myocardial infarction (AMI); the other four pa...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(82)90562-2
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:High mortality rates were reported in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary interventions (PPCI) "off-hours." The objective of this study was to evaluate this issue in a more recent population of patients with STEMI treated with PPCI in a high-volume ter...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.04.025
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Protease inhibitors (PIs) may be associated with accelerated atherosclerosis in individuals infected with human immunodeficiency virus (HIV). We assessed the effects of HIV PIs on subclinical atherosclerosis. METHODS:The lipid profiles, C-reactive protein (CRP) levels, coronary artery calcification (CAC) sc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.125009
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Acute heart failure (AHF) remains a major public health burden with a high prevalence and poor prognosis. Relaxin is a naturally occurring peptide hormone that increases cardiac output, arterial compliance, and renal blood flow during pregnancy. The RELAX-AHF-1 study will evaluate the effect of RLX030 (recom...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2011.10.009
更新日期:2012-02-01 00:00:00
abstract::A review of the clinical course of chronic heart failure demonstrates that current outcomes remain highly unsatisfactory both in mortality and perhaps more important in morbidity. The extraordinary satisfactory functional responses seen in patients who undergo cardiac transplantation clearly identify the primary cause...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(90)90056-4
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:Racial differences in cardiovascular mortality among women remain largely unexplained. Preliminary data suggest that African American and Caucasian differences in endothelial function may parallel differential cardiovascular disease (CVD) risk in women. To further study differences in endothelial function bet...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.04.032
更新日期:2004-10-01 00:00:00
abstract::Out of 156 patients with stable coronary heart disease randomized to either an exercise intervention group or a control group, 41 had complete gas analysis data. Continuous gas exchange data, including the ventilatory threshold, and selected heart rates were determined initially and at 1 year. The mean attendance for ...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(85)90548-4
更新日期:1985-03-01 00:00:00
abstract::Ambulatory ECG recordings are routinely used to identify patients at increased risk of sudden cardiac death and to monitor changes in ventricular arrhythmias during antiarrhythmic drug therapy. The arrhythmia frequency established during the initial baseline has previously been reported to change during a second place...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(88)90139-1
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Despite the known benefits of cardiac rehabilitation in patients with coronary artery disease, referral rates to rehabilitation programs remain low. We determined the incidence and determinants of cardiac rehabilitation referral rates for patients undergoing percutaneous coronary intervention (PCI). METHODS...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2010.11.016
更新日期:2011-03-01 00:00:00
abstract::Left ventricular angiography frequently produces one or more premature atrial or ventricular contractions which may make quantitative volume analysis unreliable. Three hundred left ventricular power injections were analyzed and found to produce premature ventricular contractions (PVC's) in 28 per cent of injections an...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(77)80305-0
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:Kidney failure causes anemia and is associated with a very high risk of coronary heart disease (CHD). Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both condition...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.03.055
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Peak oxygen consumption is a cornerstone for prognostic determination in patients with congestive heart failure. The purpose of this study was to assess whether plasma B-type natriuretic peptide (BNP) provided any additional prognostic information. METHODS:Plasma concentrations of atrial natriuretic peptide...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00365-X
更新日期:2003-10-01 00:00:00
abstract::We developed a new angiographic score of the extent of coronary disease (extent score), which we compared with conventional stenosis and vessel scores that emphasize the severity of stenosis. Scores were determined in 132 patients (29 women, 103 men with a mean age of 55 +/- 10 years) who underwent elective coronary a...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80173-5
更新日期:1990-06-01 00:00:00
abstract::One hundred thirty-three patients with dilated heart failure, 80 with coronary artery disease, and 53 with idiopathic dilated cardiomyopathy were followed for a mean of 29 months. Patients with ischemic heart disease had a worse prognosis than those classified as having idiopathic cardiomyopathy. Features from history...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80242-x
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Recently, long (> or =20 mm) coronary stents were introduced for clinical use. They are intended as an alternative to multiple conventional stents to treat extensive dissections or suboptimal results of long lesions after balloon angioplasty. METHODS:In a total of 113 such consecutive vessels in 107 patient...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1053/hj.1998.v136.89578
更新日期:1998-08-01 00:00:00
abstract::Six hundred fifty seven patients with angina pectoris underwent coronary angiography after measurement of plasma fibrinogen levels. Coronary artery disease (CAD) was angiographically confirmed in 75% of the patients. Other cardiac disease, either alone or in combination with CAD, was diagnosed in 8% and 11% of cases, ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90747-w
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Subcortical small vessel disease, represented as white matter hyperintensity (WMH) on magnetic resonance images (MRI) is associated with functional decline in older people with hypertension. We evaluated the relationships of clinic and out-of-office blood pressures (BP) with WMH and functional status in olde...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/j.ahj.2018.08.002
更新日期:2018-11-01 00:00:00
abstract::The aortocaval fistula is a classic model of pure cardiac volume overload in rats. This model is characterized by dilation of the ventricular cavities and eccentric cardiac hypertrophy. There are also changes in peripheral arterial flow: high flow in the proximal part of the aorta, upstream of the shunt, and low flow ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90929-4
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Although outcomes data on transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve repair (Mitraclip) are available via the Transcatheter Valve Therapy (TVT) registry, dissemination of TVT data is often delayed. The Food and Drug Administration's Manufacturer and User Facility Device Expe...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2017.10.013
更新日期:2018-04-01 00:00:00
abstract::A 47-year-old man presented with exertional angina. Selective coronary arteriography showed complete systolic segmental occlusion of the left anterior descending coronary artery producing milking effect. Permanent relief of symptoms was achieved by surgical excision of myocardial bridges. Postoperative angiography per...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90118-0
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.04.003
更新日期:2006-10-01 00:00:00
abstract::Electrolyte balance has been regarded as a factor important to cardiovascular stability, particularly in congestive heart failure. Among the common electrolytes, the significance of magnesium has been debated because of difficulty in accurate measurement and other associated factors, including other electrolyte abnorm...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/s0002-8703(96)90253-7
更新日期:1996-09-01 00:00:00
abstract::The pharmacokinetic properties and hemodynamic effect of molsidomine and its pharmacologically active metabolite SIN-1 were investigated in 13 healthy volunteers following single oral doses. Hemodynamic changes were measured by finger plethysmography (peripheral arterial resistance), impedance plethysmography (venous ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(85)90671-4
更新日期:1985-03-01 00:00:00
abstract::The acute effects of diltiazem on coronary reactive hyperemia were studied in 12 patients with flow-limiting coronary stenosis. Reactive hyperemia was elicited by injection of 8 ml contrast medium into the left coronary artery, while coronary sinus blood flow and left ventricular and aortic pressures were continuously...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90353-4
更新日期:1986-12-01 00:00:00
abstract::Left ventricular (LV) filling was examined by Doppler and M-mode echocardiography in 24 patients with LV hypertrophy (five with aortic stenosis, six with hypertrophic cardiomyopathy, and 13 with LV hypertrophy secondary to systemic hypertension) and in 18 normal subjects. Patients with LV hypertrophy had significantly...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90657-0
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Transradial approach (TRA) for cardiac catheterizations and interventions improves clinical outcomes compared with transfemoral access, and its use is increasing worldwide. However, there are limited data on successive use of same artery for repeat procedures. METHODS:Between May 2010 and May 2011, all cons...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2012.10.016
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:The human KCNE1 protein forms the β-subunit of the IKs potassium channel and is important in the regulation of the atrial action potential duration. The purpose of this study was to investigate the association between the nonsynonymous 112G>A mutation of the KCNE1 gene and postcardiac surgery atrial fibrilla...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.09.020
更新日期:2014-02-01 00:00:00
abstract::The isovolumic relaxation time (IVRT) is an important noninvasive index of left ventricular diastolic function. Despite its widespread use, however, the IVRT has not been related analytically to invasive parameters of ventricular function. Establishing such a relationship would make the IVRT more useful by itself and ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90416-s
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Enhanced external counterpulsation (EECP) reduces angina and extends time to exercise-induced ischemia in patients with symptomatic coronary disease. One- and two-center studies and a retrospective case series reported that EECP improves myocardial perfusion in stable angina pectoris. We sought to critically...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2005.01.054
更新日期:2005-11-01 00:00:00