Genetic diversity of the KCNE1 gene and susceptibility to postoperative atrial fibrillation.

Abstract:

BACKGROUND:The human KCNE1 protein forms the β-subunit of the IKs potassium channel and is important in the regulation of the atrial action potential duration. The purpose of this study was to investigate the association between the nonsynonymous 112G>A mutation of the KCNE1 gene and postcardiac surgery atrial fibrillation (AF). METHODS AND RESULTS:A cohort of patients scheduled for cardiac surgery was prospectively recruited. The genotype of 112G>A polymorphism was determined using polymerase chain reaction/restriction fragment analysis and confirmed with direct sequencing of the polymerase chain reaction product. In total, 509 patients were recruited in the study, of whom 203 (39.9%) had at least 1 qualifying episode of postoperative AF. An increased frequency of the G allele was observed in the postoperative AF group compared with the group without postoperative AF (0.628 vs 0.552, respectively, P = .016). The individual's relative risk of postoperative AF increased as the number of G alleles increased from 1.36 (95% CI 0.89-2.08) for G allele heterozygotes to 1.62 (95% CI 1.08-2.43) for G allele homozygotes (P = .04 for trend). The multivariate analysis revealed the abnormal ejection fraction (odds ratio [OR] 1.585, 95% CI 1.076-2.331, P = .020), age (OR 1.043, 95% CI 1.022-1.064, P < .001), type of surgery (aortic valve replacement) (OR 1.869, 95% CI 1.094-3.194, P = .022), and the 112G>A genotype (OR 1.401 [in additive model], 95% CI 1.052-1.865, P = .021) to be independent predictors of postoperative AF. CONCLUSION:This study confirmed the association of the 112G>A polymorphism and postoperative AF in a cohort of patients undergoing cardiac surgery.

journal_name

Am Heart J

journal_title

American heart journal

authors

Voudris KV,Apostolakis S,Karyofillis P,Doukas K,Zaravinos A,Androutsopoulos VP,Michalis A,Voudris V,Spandidos DA

doi

10.1016/j.ahj.2013.09.020

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

274-280.e1

issue

2

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(13)00713-8

journal_volume

167

pub_type

杂志文章
  • Multifaceted intervention to promote beta-blocker use in heart failure.

    abstract:BACKGROUND:Despite a survival benefit and guideline recommendation for beta-blockers in left ventricular systolic dysfunction, beta-blockers are underused in clinical practice. METHODS:Medical practices with > or = 15 patients with heart failure (HF) in the Duke Databank for Cardiovascular Disease (DDCD) were identifi...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2005.06.038

    authors: LaPointe NM,DeLong ER,Chen A,Hammill BG,Muhlbaier LH,Califf RM,Kramer JM

    更新日期:2006-05-01 00:00:00

  • Postoperative abnormalities of interventricular septal motion: two-dimensional and M-mode echocardiographic correlations.

    abstract::Our hypothesis was that the postoperative abnormalities in septal motion observed by M-mode echocardiography (MME) are due to changes of either ventricular shape or of total cardiac motion within the thorax. We obtained preoperative and early and late postoperative MME and two-dimensional echocardiograms on 25 patient...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90202-2

    authors: Kerber RE,Litchfield R

    更新日期:1982-08-01 00:00:00

  • Sinus node recovery times following the spontaneous termination of supraventricular tachycardia and following atrial overdrive pacing: a comparison.

    abstract::We compared the pauses that followed the spontaneous termination of supraventricular tachyarrhythmias with the pauses that followed the cessation of atrial overdrive pacing in 21 patients. In 10 patients with abnormal sinus node function and in 11 patients with normal sinus node function we recorded the spontaneous te...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90515-x

    authors: Gang ES,Reiffel JA,Livelli FD Jr,Bigger JT Jr

    更新日期:1983-02-01 00:00:00

  • An open, noncomparative study of doxazosin in essential hypertension: experience in general practice in The Netherlands.

    abstract::The antihypertensive efficacy, safety, and lipid effects of doxazosin, a selective alpha 1-inhibitor, were assessed in a general practice setting. Three hundred twenty-six patients were entered into the study, which involved three phases: (1) a 2-week baseline period, (2) an 8-week period in which patients received 1 ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(91)90857-e

    authors: Naber FB

    更新日期:1991-01-01 00:00:00

  • Recent trends in the incidence rates of and death rates from atrial fibrillation complicating initial acute myocardial infarction: a community-wide perspective.

    abstract:BACKGROUND:Limited information is available about recent trends in the incidence and death rates from atrial fibrillation (AF) complicating acute myocardial infarction (AMI). The purpose of this study was to examine the impact and trends over time of AF complicating initial AMI. METHODS:We conducted a longitudinal stu...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1067/mhj.2002.120410

    authors: Goldberg RJ,Yarzebski J,Lessard D,Wu J,Gore JM

    更新日期:2002-03-01 00:00:00

  • Statin use in heart failure: a cause for concern?

    abstract:BACKGROUND:Statins are effective in the prevention of coronary events and the treatment of acute coronary syndromes. However, their efficacy and safety in patients with heart failure (HF) are unknown. In this review, we discuss the evidence for the efficacy and safety of statin therapy in patients with HF. METHODS:We ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2005.09.008

    authors: Raina A,Pickering T,Shimbo D

    更新日期:2006-07-01 00:00:00

  • Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study.

    abstract:BACKGROUND:A shortcoming of the pediatric electrocardiogram (ECG) appears to be its inability to accurately detect left ventricular hypertrophy (LVH). This study prospectively assesses the usefulness of the pediatric ECG as a screening modality for LVH. METHODS:Concomitant echocardiograms and ECGs from a large cohort ...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1067/mhj.2003.15

    authors: Rivenes SM,Colan SD,Easley KA,Kaplan S,Jenkins KJ,Khan MN,Lai WW,Lipshultz SE,Moodie DS,Starc TJ,Sopko G,Zhang W,Bricker JT,Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Grou

    更新日期:2003-04-01 00:00:00

  • Effect of statin dose on incidence of atrial fibrillation: data from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) and Aggrastat to Zocor (A to Z) trials.

    abstract:BACKGROUND:Inflammation has been suggested as a factor in the initiation and maintenance of atrial fibrillation (AF). Several observational studies have suggested that statins, presumably through their anti-inflammatory properties, decrease the risk of AF. METHODS:We analyzed 2 large, randomized trials, PROVE IT-TIMI ...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.10.024

    authors: McLean DS,Ravid S,Blazing M,Gersh B,Shui A,Cannon CP

    更新日期:2008-02-01 00:00:00

  • Enoxaparin versus tinzaparin in non-ST-segment elevation acute coronary syndromes: the EVET trial.

    abstract:BACKGROUND:Low-molecular weight heparins have different pharmacokinetic and pharmacodynamic characteristics and may vary in efficacy. We compared the efficacy of enoxaparin with that of tinzaparin in the management of non-ST-segment elevation acute coronary syndromes (NSTACS). METHODS:A total of 438 patients with NSTA...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0002-8703(03)00179-0

    authors: Michalis LK,Katsouras CS,Papamichael N,Adamides K,Naka KK,Goudevenos J,Sideris DA

    更新日期:2003-08-01 00:00:00

  • Open clinical studies at a referral center: chronic maintenance tocainide therapy in patients with recurrent sustained ventricular tachycardia refractory to conventional antiarrhythmic agents.

    abstract::Chronic maintenance tocainide therapy was effective in controlling symptomatic, recurrent ventricular tachycardia in 11 of 15 patients. Patients were selected for tocainide therapy on the basis of refractoriness to conventional antiarrhythmic agents and responsiveness to the intravenous administration of lidocaine. Si...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90208-2

    authors: Maloney JD,Nissen RG,McColgan JM

    更新日期:1980-12-01 00:00:00

  • Atherosclerosis: an update.

    abstract::CHD remains the leading cause of death in most developed countries; therefore, elucidation of risk factors and associated mechanisms for atherosclerosis and development of CHD has been a high priority. Data from the Framingham Heart Study and other large-scale epidemiologic studies have identified major risk factors a...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-8703(96)90096-4

    authors: Basha BJ,Sowers JR

    更新日期:1996-06-01 00:00:00

  • Holter-guided identification of premature ventricular contractions susceptible to suppression by beta-blockers.

    abstract::To evaluate whether the identification of the different types of relations between premature ventricular contractions (PVCs) and the preceding sinus cycle length is capable of predicting the effect of beta-blockers on the PVCs themselves, 55 patients (43 men, 12 women, mean age 52.6 +/- 15.6 years) with different card...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0002-8703(96)90529-3

    authors: Pitzalis MV,Mastropasqua F,Massari F,Totaro P,Di Maggio M,Rizzon P

    更新日期:1996-03-01 00:00:00

  • Presyncopal sympathetic withdrawal is the same in patients with vasodepressor syncope and controls who faint on head-up tilting.

    abstract::Head-up tilt provokes vasodepressor syncope in patients with this disorder but may also cause fainting in unaffected subjects. The aims of this study were to examine autonomic function and sequential changes in heart rate variability and plasma catecholamines during graded head-up tilt in patients with vasodepressor s...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)70213-8

    authors: Prinz-Zaiss M,Yeap AN,Moguilevski V,Trigg L,McGrath BP

    更新日期:1997-02-01 00:00:00

  • Effects of intra-aortic balloon counterpulsation on coronary pressure in patients with stenotic coronary arteries.

    abstract:BACKGROUND:The benefits of intra-aortic balloon pumping (IABP) usage reportedly occur through systolic unloading of the left ventricle and the augmentation of diastolic coronary flow. The aim of this study was to assess the change in intracoronary pressure distal to the coronary stenosis after the IABP by using an intr...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.05.019

    authors: Yoshitani H,Akasaka T,Kaji S,Kawamoto T,Kume T,Neishi Y,Koyama Y,Yoshida K

    更新日期:2007-10-01 00:00:00

  • New phenotype of familial dilated cardiomyopathy and conduction disorders.

    abstract:BACKGROUND:Familial dilated cardiomyopathy (FDCM) is attributed to defects in cytoskeletal proteins, and different patterns of inheritance and phenotypic expressions according to assorted-protein modifications have been identified to date. We describe a clinical family study with 24 individuals in 3 generations affecte...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2003.141

    authors: Oropeza ES,Cadena CN

    更新日期:2003-02-01 00:00:00

  • Neighborhood socioeconomic disparities and 1-year case fatality after incident myocardial infarction: the Atherosclerosis Risk in Communities (ARIC) Community Surveillance (1992-2002).

    abstract:BACKGROUND:Declines in case fatality post-myocardial infarction (MI) have been observed over the past 3 decades. Few studies report socioeconomic disparities in survival post-MI. METHODS:We assessed 1-year case fatality among 9,116 incident MI patients included in the Atherosclerosis Risk in Communities community surv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2012.10.022

    authors: Foraker RE,Patel MD,Whitsel EA,Suchindran CM,Heiss G,Rose KM

    更新日期:2013-01-01 00:00:00

  • Effects of indomethacin on systemic and coronary hemodynamics in patients with coronary artery disease.

    abstract::The effects and possible mechanisms of actions of indomethacin on systemic and coronary hemodynamics were studied in 17 patients with coronary artery disease. Group I patients (12) were given either indomethacin or placebo in the absence of prior cyclooxygenase inhibition and group II (five) were given indomethacin af...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(85)90149-8

    authors: Forman MB,Uderman H,Jackson EK,Roy L,Bostick D,Robertson D,Robertson RM

    更新日期:1985-08-01 00:00:00

  • Weight change after myocardial infarction--the Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) experience.

    abstract:BACKGROUND:The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial. METHODS:From the ENRICHD trial data, we assessed weight change, and the associations of baseline weight and change at follow-up with outcomes and interactions between psychosocial factors. RESUL...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.10.026

    authors: Lopez-Jimenez F,Wu CO,Tian X,O'Connor C,Rich MW,Burg MM,Sheps D,Raczynski J,Somers VK,Jaffe AS

    更新日期:2008-03-01 00:00:00

  • Prognostic value of C-reactive protein levels within six hours after the onset of acute myocardial infarction.

    abstract:BACKGROUND:Inflammation is an important feature of atherosclerotic lesions, and the vulnerability of coronary lesions in acute myocardial infarction (AMI) at the time of onset may be related to blood levels of C-reactive protein (CRP) on admission, before CRP levels are affected by myocardial damage. METHODS:A total o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.108244

    authors: Tomoda H,Aoki N

    更新日期:2000-08-01 00:00:00

  • Effect of verapamil on conduction delay produced by myocardial ischemia and reperfusion.

    abstract::Changes in conduction times induced by ischemia (delta CT) have been shown to be quantitatively related to genesis of spontaneous ischemic ventricular fibrillation (VF). We studied conduction delay encountered by premature impulses in epicardium and endocardium in both anterograde and retrograde directions during isch...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(81)90308-2

    authors: Hamamoto H,Peter T,Fujimoto T,Mandel WJ

    更新日期:1981-09-01 00:00:00

  • Changes in glycoprotein IIb/IIIa inhibitor excess dosing with site-specific safety feedback in the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) initiative

    abstract:BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors can improve outcomes in patients with non-ST-segment elevation acute coronary syndromes but raise the risk of bleeding, particularly if dosed in excess. The impact of GP IIb/IIIa dosing feedback on safety and major bleeding is unknown. METHODS:Glycoprotein IIb/IIIa dosi...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2010.08.008

    authors: Mudrick DW,Chen AY,Roe MT,Newby LK,Gibler WB,Ohman EM,Peterson ED,Alexander KP

    更新日期:2010-12-01 00:00:00

  • Vasodilatation with felodipine in chronic asymptomatic aortic regurgitation.

    abstract:BACKGROUND:Afterload reduction decreases volume overload on the left ventricle and may thereby delay the need for valve replacement in chronic asymptomatic aortic regurgitation. The aims of this randomized double-blind, placebo-controlled trial were to examine short- and long-term hemodynamic effects of felodipine in c...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(00)90046-2

    authors: Søndergaard L,Aldershvile J,Hildebrandt P,Kelbaek H,Ståhlberg F,Thomsen C

    更新日期:2000-04-01 00:00:00

  • Temporal trends in pharmacotherapy for congestive heart failure at an academic medical center: 1990-1995.

    abstract::The objectives of this study were to assess current practice patterns in pharmacotherapy for congestive heart failure at an academic medical center and to analyze temporal trends in management of congestive heart failure from 1990 to 1995. Records of all patients discharged from the hospital in 1990 or 1995 with a pri...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70309-6

    authors: Rich MW,Brooks K,Luther P

    更新日期:1998-03-01 00:00:00

  • Rapid, sensitive detection of myoglobulinemia by improved counterimmunoelectrophoresis in cases of acute myocardial infarction.

    abstract::A counterimmunoelectrophoresis technique for detection of serum myoglobin (Mb) was improved using non-ionic polymer dextran. Precipitin lines were graded according to their strength, which was ascertained by radioimmunoassay data. By this method, serum Mb in concentrations of 500 ng./ml. before stain and of 200 ng./ml...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90084-4

    authors: Hiramori K,Sumiyoshi T,Motegi S,Honda T,Kimata S,Hirosawa K,Kawai H,Kondo A,Iwaasa M,Miyoshi K

    更新日期:1978-08-01 00:00:00

  • Predictive value of immunofluorescence and electron microscopic evaluation of endomyocardial biopsies in the diagnosis and prognosis of myocarditis and idiopathic dilated cardiomyopathy.

    abstract::The distinction between idiopathic dilated cardiomyopathy and myocarditis is controversial, both clinically and pathologically. To increase diagnostic accuracy and provide prognostic information, we prospectively tested the routine application of immunofluorescence and electron microscopy in endomyocardial biopsy eval...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90180-3

    authors: Hammond EH,Menlove RL,Anderson JL

    更新日期:1987-11-01 00:00:00

  • Efficacy and safety of quinapril in the elderly hypertensive patient.

    abstract::The efficacy and safety of once-daily administration of the new angiotensin-converting enzyme inhibitor quinapril or quinapril plus hydrochlorothiazide (HCTZ) were assessed in 64 older (greater than 65 years) patients with mild to moderate hypertension in an uncontrolled, open-label study. Treatment was initiated with...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(92)91065-9

    authors: Forette B,Koen R,Vicaut E

    更新日期:1992-05-01 00:00:00

  • The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations.

    abstract::Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clin...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2015.03.002

    authors: Roe MT,Mahaffey KW,Ezekowitz JA,Alexander JH,Goodman SG,Hernandez A,Temple T,Berdan L,Califf RM,Harrington RA,Peterson ED,Armstrong PW

    更新日期:2015-06-01 00:00:00

  • Safety of radiofrequency catheter ablation of accessory atrioventricular pathways.

    abstract::The acute anatomic and valvular consequences of radiofrequency catheter ablation of accessory pathways were evaluated in 62 patients by means of serial echocardiographic examinations. Semiquantitative assessment of valvular incompetence and classification into one of four grades according to the width and the extensio...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90382-4

    authors: Metzger JT,Cheriex EC,Smeets JL,Vanagt E,Rodriguez LM,Pieters FA,Weide A,Wellens HJ

    更新日期:1994-06-01 00:00:00

  • Differences in mortality in acute coronary syndrome symptom clusters.

    abstract:BACKGROUND:The timely and accurate identification of symptoms of acute coronary syndrome (ACS) is a challenge for patients and clinicians. It is unknown whether response times and clinical outcomes differ with specific symptoms. We sought to identify which ACS symptoms are related-symptom clusters-and to determine if s...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2010.01.003

    authors: Riegel B,Hanlon AL,McKinley S,Moser DK,Meischke H,Doering LV,Davidson P,Pelter MM,Dracup K

    更新日期:2010-03-01 00:00:00

  • Depressed arterial baroreflex sensitivity and not reduced heart rate variability identifies patients with chronic heart failure and nonsustained ventricular tachycardia: the effect of high ventricular filling pressure.

    abstract::In chronic heart failure (CHF) the contributing role of increased sympathetic activity and hemodynamic dysfunction in the genesis of ventricular arrhythmias has not been well established. To assess the relation between severe ventricular arrhythmias, hemodynamic impairment, and autonomic nervous system derangement, 14...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)80011-7

    authors: Mortara A,La Rovere MT,Pinna GD,Parziale P,Maestri R,Capomolla S,Opasich C,Cobelli F,Tavazzi L

    更新日期:1997-11-01 00:00:00