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Vitamin K epoxide reductase complex subunit 1 gene polymorphism is associated with atherothrombotic complication after drug-eluting stent implantation: 2-Center prospective cohort study.

Abstract：

BACKGROUND:Single nucleotide polymorphisms of vitamin K epoxide reductase complex subunit 1 (VKORC1) was reported to have association with arterial vascular disease. We investigated whether single nucleotide polymorphism of VKORC1 +2255 is associated with clinical outcomes among patients who underwent drug-eluting stent (DES) implantation. METHODS:We prospectively collected genomic DNA in patients who underwent DES deployment from September 2003 to December 2006 and compared clinical outcomes according to their VKORC1 genotype at the locus + 2255 (rs 2359612). The primary end point was composite of atherothrombotic events (cardiac death, myocardial infarction, and nonhemorrhagic stroke). RESULTS:Mean follow-up duration was 631 +/- 251 days. Genotyping was completed in 764 cases (TT genotype [n = 640, 83.8%] vs non-TT [CC or CT] genotype [n = 124, 16.2%]). Non-TT group showed more composite events than TT group (7.3% vs 3.0%, P = .032). In the Cox regression analysis, non-TT genotype of VKORC gene was a significant predictor of atherothrombotic events (hazard ratio 2.56, 95% confidence interval 1.14-5.78). In the event-free survival analysis, non-TT group also showed significantly poorer cardiovascular events-free survival rate than TT group (P = .02). CONCLUSIONS:VKORC1 genotype is associated with cardiovascular events in patients with DES implantation, suggesting the role of coagulation system.

journal_name

Am Heart J

journal_title

American heart journal

authors

Suh JW,Baek SH,Park JS,Kang HJ,Chae IH,Choi DJ,Park HJ,Kim PJ,Seung KB,Kim HS

doi

10.1016/j.ahj.2009.02.001

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

908-12

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(09)00102-1

journal_volume

157

pub_type

杂志文章,多中心研究

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