Pulmonary artery hypertension in severe aortic stenosis: incidence and mechanism.

Abstract:

:We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH (pulmonary artery systolic pressure > 50 mm Hg); group 2 comprised 32 patients (71%) without PAH. Group 1 patients had a higher incidence of congestive heart failure, a lower left ventricular ejection fraction and cardiac index, and more mitral regurgitation as compared with group 2 patients. Of the 13 group 1 patients, 8 had a transpulmonary gradient (pulmonary artery mean pressure--pulmonary capillary wedge pressure) > or = 10 mm Hg, consistent with reactive PAH. We conclude that PAH frequently accompanies aortic stenosis and is often reactive.

journal_name

Am Heart J

journal_title

American heart journal

authors

Silver K,Aurigemma G,Krendel S,Barry N,Ockene I,Alpert J

doi

10.1016/0002-8703(93)90067-j

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

146-50

issue

1

eissn

0002-8703

issn

1097-6744

pii

0002-8703(93)90067-J

journal_volume

125

pub_type

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