Abnormal quinidine binding in survivors of prehospital cardiac arrest.

abstract：BACKGROUND:Bleeding is associated with adverse outcome in acute coronary syndromes. However, the precise pathophysiologic mechanisms have not been elucidated. We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their i...

journal_title：American heart journal

authors： Yan AT,Yan RT,Huynh T,DeYoung P,Weeks A,Fitchett DH,Langer A,Goodman SG,INTERACT Investigators.

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The Gly16 beta(2)-adrenergic receptor (beta(2)AR) polymorphism is a common variant of the beta(2)AR that displays depressed function caused by enhanced receptor downregulation in vitro compared with the Arg16 receptor. METHODS AND RESULTS:We studied 20 healthy, normotensive, nonsmoking white individuals who...

journal_title：American heart journal

authors： Hoit BD,Suresh DP,Craft L,Walsh RA,Liggett SB

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Anginal chest pain without creatine kinase (CK) elevation is frequently observed in the first hours after coronary stenting. Possible causes of ischemic episodes are microembolism, side branch occlusion, coronary vasospasm, and disturbances of microvascular circulation. In a prospective, double-blind, random...

journal_title：American heart journal

authors： Kurz DJ,Naegeli B,Bertel O

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Galectin-3, a β-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. METHODS:We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the...

journal_title：American heart journal

authors： Fashanu OE,Norby FL,Aguilar D,Ballantyne CM,Hoogeveen RC,Chen LY,Soliman EZ,Alonso A,Folsom AR

更新日期：2017-10-01 00:00:00

abstract：:Percutaneous balloon mitral valvuloplasty has been shown to be an effective means of reducing mitral valve gradient and increasing mitral valve area in patients with mitral stenosis. Most techniques currently employed for performing this procedure involve delivery of one or two balloon valvuloplasty catheters through ...

journal_title：American heart journal

authors： Fields CD,Slovenkai GA,Isner JM

更新日期：1990-03-01 00:00:00

abstract：:Digoxin intoxication has been reported to be a common adverse drug reaction with an in-hospital incidence of 6% to 23% and an associated mortality rate as high as 41%. A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hos...

journal_title：American heart journal

authors： Mahdyoon H,Battilana G,Rosman H,Goldstein S,Gheorghiade M

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...

journal_title：American heart journal

authors： Gibson CM,Halaby R,Korjian S,Daaboul Y,Arbetter DF,Yee MK,Goldhaber SZ,Hull R,Hernandez AF,Lu SP,Bandman O,Leeds JM,Gold A,Harrington RA,Cohen AT,APEX Investigators.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Erectile dysfunction (ED) is a common disorder in middle-aged men and is significantly influenced by cardiovascular risk factors (CVRFs) and cardiovascular disease. The substudy of the ONTARGET/TRANSCEND trials evaluates the relationship of erectile function to baseline characteristics and current treatment ...

journal_title：American heart journal

authors： Böhm M,Baumhäkel M,Probstfield JL,Schmieder R,Yusuf S,Zhao F,Koon T,ONTARGET\/TRANSCEND ED-Investigators.

更新日期：2007-07-01 00:00:00

abstract：:Nearly 800,000 of the 1 million patients hospitalized with acute heart failure (AHF) every year are initially treated by emergency physicians. Signs and symptoms are typically most severe at initial presentation, but with timely diagnostic and therapeutic management, rapid improvement can be achieved. As a direct resu...

journal_title：American heart journal

authors： Collins SP,Levy PD,Pang PS,Gheorghiade M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Reliable predictors have yet to be found for recurrent ischemia after thrombolysis for acute myocardial infarction (AMI), nor do we know whether early angiography can herald recurrent ischemia. This study sought to investigate the relationship between recurrent ischemia and cardiac procedures after thromboly...

journal_title：American heart journal

authors： Pilote L,Miller DP,Califf RM,Topol EJ,Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) Investigators.

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is a...

journal_title：American heart journal

authors： Kolek MJ,Carlquist JF,Muhlestein JB,Whiting BM,Horne BD,Bair TL,Anderson JL

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Pharmacodynamic studies reported an amplified on-clopidogrel platelet inhibition in smokers potentially caused by an increased metabolic drug activation via induction of cytochrome P450 1A2. The aims of this analysis were to evaluate the impact of smoking on the antiplatelet effect of clopidogrel and prasugr...

journal_title：American heart journal

authors： Hochholzer W,Trenk D,Mega JL,Morath T,Stratz C,Valina CM,O'Donoghue ML,Bernlochner I,Contant CF,Guo J,Sabatine MS,Schömig A,Neumann FJ,Kastrati A,Wiviott SD,Sibbing D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus (DM) experience higher rates of in-stent restenosis and greater benefit from drug-eluting stents implant at the time of percutaneous coronary intervention (PCI), necessitating prolonged dual anti-platelet therapy (DAPT). While DAPT reduces risk of ischemic events post-PCI, it ...

journal_title：American heart journal

authors： Grodzinsky A,Arnold SV,Wang TY,Sharma P,Gosch K,Jones PG,Bhatt DL,Steg PG,McGuire DK,Cohen DJ,Spertus JA,Chhatriwalla AK,Lind M,Graham G,Kosiborod M

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Recently, long (> or =20 mm) coronary stents were introduced for clinical use. They are intended as an alternative to multiple conventional stents to treat extensive dissections or suboptimal results of long lesions after balloon angioplasty. METHODS:In a total of 113 such consecutive vessels in 107 patient...

journal_title：American heart journal

authors： De Scheerder IK,Wang K,Kostopoulos K,Dens J,Desmet W,Piessens JH

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:In adults with an atrial septal defect (ASD) transcatheter closure leads to an improvement of peak oxygen uptake (VO2), but the kinetics of recovery of VO2 after maximal exercise in this patient population and the impact of transcatheter ASD closure have never been investigated. METHODS:Twenty consecutive p...

journal_title：American heart journal

authors： Giardini A,Donti A,Specchia S,Coutsoumbas G,Formigari R,Prandstraller D,Bronzetti G,Bonvicini M,Picchio FM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain. METHODS:In the EFFECT study, we determined the association between cardiac troponin I and all-cause mo...

journal_title：American heart journal

authors： You JJ,Austin PC,Alter DA,Ko DT,Tu JV

更新日期：2007-04-01 00:00:00

abstract：:The purpose of this study was to determine the effect of age on the in-hospital mortality of all 30,972 patients undergoing coronary artery bypass graft (CABG) surgery in New York in 1991 and 1992. Mortality rates were relatively low for patients 40-49, 50-59, and 60-64, 65-69, and 70-74 years old (1.10%, 1.65%, 2.17%...

journal_title：American heart journal

authors： Hannan EL,Burke J

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) complicated by cardiogenic shock (CS) is associated with high mortality. Early coronary revascularization improves survival, but the optimal mode of revascularization remains uncertain. We sought to characterize practice patterns and outcomes of coronary artery bypass grafting (CAB...

journal_title：American heart journal

authors： Smilowitz NR,Alviar CL,Katz SD,Hochman JS

更新日期：2020-08-01 00:00:00

abstract：:A pilot study was performed to determine the safety and efficacy of coronary pulsed mid-infra-red laser angioplasty. The laser was coupled with a novel 2.0 mm multifiber catheter consisting of 37 optical fibers of 150 microns each arranged concentrically around a 0.018-inch central lumen and a soft leading tapered dis...

journal_title：American heart journal

authors： Geschwind HJ,Dubois-Rande JL,Zelinsky R,Morelle JF,Boussignac G

更新日期：1991-08-01 00:00:00

abstract：:Intravascular thrombus often occurs when the rupture or fissure of an atherosclerotic plaque exposes procoagulant elements lying below the plaque surface. This process of plaque rupture is the result both of passive mechanical forces and an active cell-mediated mechanism. Recently a number of investigators have develo...

journal_title：American heart journal

authors： Fuster V

更新日期：1998-06-01 00:00:00

abstract：:High degree AV block occurred in 144 of 843 patients consecutively admitted because of acute inferior myocardial infarction and was associated with more extensive myocardial damage and a higher mortality rate, as compared to those without AV block. Patients with power failure at the time of appearance of high degree A...

journal_title：American heart journal

authors： Tans AC,Lie KI,Durrer D

更新日期：1980-01-01 00:00:00

abstract：:The acute and chronic cellular electrophysiologic actions of ketanserin, a selective blocker of 5-hydroxytriptamine (5-HT2) receptor, were examined in the isolated rabbit ventricular muscle. This work was prompted by the recent observations that small numbers of patients treated with hypertension develop QTc prolongat...

journal_title：American heart journal

authors： Kamiya K,Venkatesh N,Singh BN

更新日期：1988-06-01 00:00:00

abstract：:The Lown grading system uses three levels of frequency and four complex features to grade ventricular arrhythmias. The seven Lown grades are mutually exclusive (a patient can be in only one grade) and hierarchical (higher grades indicate increased likelihood of death). We evaluated the ability of the Lown arrhythmia g...

journal_title：American heart journal

authors： Bigger JT Jr,Weld FM

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:We sought to systematically evaluate whether percutaneous revascularization is associated with additional clinical benefit in patients with renal artery stenosis (RAS) as compared with medical management alone. METHODS:We included randomized controlled trials that compared percutaneous revascularization in ...

journal_title：American heart journal

authors： Kumbhani DJ,Bavry AA,Harvey JE,de Souza R,Scarpioni R,Bhatt DL,Kapadia SR

更新日期：2011-03-01 00:00:00

abstract：:Recent experimental and clinical data have stimulated interest in the use of alpha-adrenergic antagonists in acute myocardial infarction. We evaluated nicergoline, a new relatively selective alpha 1-antagonist which uniquely lowers heart rate. Open-chest dogs, randomized to control (n = 25) or intravenously treated gr...

journal_title：American heart journal

authors： Bolli R,Brandon TA,Fisher DJ,Fernandez GC,Miller RR

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Peak exercise oxygen consumption (peak VO2) is an important discriminator of survival in patients with systolic heart failure and is used to select ambulatory patients for transplantation. The major trials assessing the relationship between peak VO2 and survival have used a variety of low-level exercise prot...

journal_title：American heart journal

authors： Strzelczyk TA,Cusick DA,Pfeifer PB,Bondmass MD,Quigg RJ

更新日期：2001-09-01 00:00:00

abstract：:Asymptomatic atrial fibrillation (AF) is common and may have the same prognostic implications as symptomatic AF. Among patients receiving dual-chamber pacemakers, it is now possible to quantify asymptomatic AF accurately. Most of these episodes are of short duration, often lasting only seconds to minutes and are calle...

journal_title：American heart journal

authors： Hohnloser SH,Capucci A,Fain E,Gold MR,van Gelder IC,Healey J,Israel CW,Lau CP,Morillo C,Connolly SJ,ASSERT Investigators and Committees.

更新日期：2006-09-01 00:00:00

abstract：:We evaluated the use of simple balloon overinflation to induce neointimal hyperplasia in a porcine model of coronary artery restenosis. By using standard percutaneous transluminal coronary angioplasty techniques, left anterior descending (LAD) and/or left circumflex (LCX) coronary arteries of either juvenile feeder pi...

journal_title：American heart journal

authors： Humphrey WR,Simmons CA,Toombs CF,Shebuski RJ

更新日期：1994-01-01 00:00:00

abstract：:The serum chromium in 45 subjects with no clinical evidence of ischemic heart disease was found to be 1.71 parts per billion (ppb) (S.E. +/- 0.14). In 34 patients with a previously documented myocardial infarction, it was 1.84 ppb (S.E. +/- 0.18). The difference was not significant nor was there any difference with ag...

journal_title：American heart journal

authors： Abraham AS,Sonnenblick M,Eni M,Shemesh O,Batt AP

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Elevated resting heart rate (RHR) is known to be associated with reduced survival but inconsistencies remain, including lack of significance in most studies of healthy women, lack of independence from systolic blood pressure (SBP) in some, and the suggestion that RHR is merely functioning as a marker of phys...

journal_title：American heart journal

authors： Cooney MT,Vartiainen E,Laatikainen T,Juolevi A,Dudina A,Graham IM

更新日期：2010-04-01 00:00:00