当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals.

beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals.

Abstract：

BACKGROUND:The Gly16 beta(2)-adrenergic receptor (beta(2)AR) polymorphism is a common variant of the beta(2)AR that displays depressed function caused by enhanced receptor downregulation in vitro compared with the Arg16 receptor. METHODS AND RESULTS:We studied 20 healthy, normotensive, nonsmoking white individuals who were homozygous for either the Arg16 (n = 10) or the Gly16 (n = 10) genotype. Plethysmographic lower-limb blood flow, blood pressure, and 2-dimensional echocardiograms were recorded at baseline and after 15-minute incremental infusions of terbutaline (100 to 300 ng/kg per minute). Baseline heart rates, blood pressures, and flows were similar in both groups, but at the maximum dose of terbutaline, limb blood flow was less (P <.05), calculated vascular resistance was greater (P <.05), and systolic and diastolic blood pressures were greater in patients with Gly16 than in those with Arg16 (both P <.05). In contrast, terbutaline-stimulated heart rates were not different. In a separate group of 20 homozygous individuals (12 Arg16, 8 Gly16), there were no differences in 2-dimensional echocardiographically determined ventricular function. CONCLUSIONS:We conclude that the Gly16 beta(2)AR polymorphism imparts attenuated vasodilatory responses to catecholamines in normal human beings and is an important genetic component in the regulation of peripheral blood flow and systemic arterial pressure.

journal_name

Am Heart J

journal_title

American heart journal

authors

Hoit BD,Suresh DP,Craft L,Walsh RA,Liggett SB

doi

10.1016/s0002-8703(00)90099-1

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

537-42

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(00)90099-1

journal_volume

139

pub_type

临床试验,杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking.

    abstract：BACKGROUND:Moderate alcohol drinking and marine omega-3 fatty acids (omega3) have both been associated with low mortality from coronary heart disease (CHD). However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients. METHODS:The relationships between wine drinking an...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2007.08.009

    authors： de Lorgeril M,Salen P,Martin JL,Boucher F,de Leiris J

    更新日期：2008-01-01 00:00:00

  • Age and outcome after acute coronary syndromes without persistent ST-segment elevation.

    abstract：BACKGROUND:Although age is the most important variable associated with death among patients with persistent ST-segment elevation, its impact on outcome among patients without persistent ST-segment elevation remains unknown. Moreover, the impact of age on the efficacy of antiplatelet therapy with eptifibatide is unknown...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(00)90018-8

    authors： Hasdai D,Holmes DR Jr,Criger DA,Topol EJ,Califf RM,Harrington RA

    更新日期：2000-05-01 00:00:00

  • How does warfarin affect the activated coagulation time?

    abstract：BACKGROUND:The activated coagulation time (ACT) is a rapid measurement of a patient's level of heparin anticoagulation during cardiac catheterization. Patients receiving warfarin therapy occasionally are seen at the catheterization laboratory for emergent procedures. The effects of warfarin on ACT activity have not bee...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70223-6

    authors： Chang RJ,Doherty TM,Goldberg SL

    更新日期：1998-09-01 00:00:00

  • CardioSEAL/STARflex versus Amplatzer devices for percutaneous closure of small to moderate (up to 18 mm) atrial septal defects.

    abstract：BACKGROUND:The Amplatzer septal occluder (ASO) allows the percutaneous closure of small to very large atrial septal defects (ASDs). The CardioSEAL/STARflex (CS/SF) can be used only for closure of small to moderate ASDs (stretch size up to 18 mm). These 2 devices are widely used in clinical practice. Therefore, a compar...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.03.013

    authors： Butera G,Carminati M,Chessa M,Delogu A,Drago M,Piazza L,Giamberti A,Frigiola A

    更新日期：2004-09-01 00:00:00

  • Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial.

    abstract：BACKGROUND:Bleeding is associated with adverse outcome in acute coronary syndromes. However, the precise pathophysiologic mechanisms have not been elucidated. We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their i...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2008.05.022

    authors： Yan AT,Yan RT,Huynh T,DeYoung P,Weeks A,Fitchett DH,Langer A,Goodman SG,INTERACT Investigators.

    更新日期：2008-10-01 00:00:00

  • Effects of substrate availability on myocardial C-11 palmitate kinetics by positron emission tomography in normal subjects and patients with ventricular dysfunction.

    abstract：:The possibility of demonstrating noninvasively with C-11 palmitate and positron emission tomography (PET) changes in myocardial substrate metabolism in normal and diseased human myocardium in response to altered substrate availability in blood and disease-related abnormalities was examined in five normal volunteers an...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(86)90006-2

    authors： Schelbert HR,Henze E,Sochor H,Grossman RG,Huang SC,Barrio JR,Schwaiger M,Phelps ME

    更新日期：1986-06-01 00:00:00

  • Modern approaches to the diagnosis of coronary artery disease.

    abstract：:Atherosclerotic coronary artery disease is a serious clinical problem. Clinicians dealing with patients can make a diagnosis of coronary disease in several ways. Unfortunately all too often the diagnosis is made via sudden death or acute myocardial infarction. At other times the diagnosis is made by evaluation of pati...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(92)91039-4

    authors： Anderson HV,King SB 3rd

    更新日期：1992-05-01 00:00:00

  • Dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging: a new marker of triple-vessel disease.

    abstract：:To investigate the significance and mechanism of dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging, we performed both dipyridamole thallium-201 imaging and dipyridamole radionuclide angiography on 83 patients with known angiograms. The dipyridamole/delayed ratio of the left ventricular dim...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90713-r

    authors： Takeishi Y,Tono-oka I,Ikeda K,Komatani A,Tsuiki K,Yasui S

    更新日期：1991-02-01 00:00:00

  • Baseline characteristics of patients in the coronary artery bypass graft (CABG) Patch Trial.

    abstract：BACKGROUND:Patients with left ventricular dysfunction who undergo coronary artery bypass graft (CABG) surgery frequently have late sudden cardiac death. The CABG Patch Trial is a prospective, randomized, multicenter clinical trial that randomized patients at high risk at the completion of CABG surgery to implantation o...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(97)80001-4

    authors： Curtis AB,Cannom DS,Bigger JT Jr,DiMarco JP,Estes NA 3rd,Steinman RC,Parides MK

    更新日期：1997-11-01 00:00:00

  • Evaluation of mitral valve prolapse by four-dimensional echocardiography.

    abstract：:To observe the stereoscopic structure and the motion of the prolapsing mitral valve and its regurgitant jet in comparison with the normal mitral valve, four-dimensional (or dynamic three-dimensional) echocardiography of mitral valve apparatus was obtained in 20 patients with mitral valve prolapse and 10 unaffected sub...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(97)70257-6

    authors： Cheng TO,Xie MX,Wang XF,Li ZA,Hu G

    更新日期：1997-01-01 00:00:00

  • Effects of nonsurgical myocardial reperfusion on plasma creatine kinase kinetics in man.

    abstract：:The rate and form of creatine kinase-MB (CK-MB) enzyme release following reflow to ischemic myocardium has not been specifically examined in man. In this investigation, we examined the combined CK-MB time-activity curves during acute transmural myocardial infarction (AMI) in a group of patients receiving conventional ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90084-4

    authors： Shell W,Mickle DK,Swan HJ

    更新日期：1983-10-01 00:00:00

  • Isolated T wave alternans.

    abstract：:Two patients with isolated T wave alternans are reported, with their vectocardiograms, their response to carotid sinus stimulation, and the response to calcium infusion in one of them with documented severe hypocalcemia. Eleven cases of the literature are briefly reviewed. The alternans of the T wave appears with seve...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90369-1

    authors： Navarro-Lopez F,Cinca J,Sanz G,Periz A,Magriña J,Betriu A

    更新日期：1978-03-01 00:00:00

  • Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies.

    abstract：OBJECTIVES:We analyzed the antiplatelet effects of different P2Y(12) receptor blockers with VerifyNow P2Y12 assay (VN-P2Y12) and light transmittance aggregometry (LTA). BACKGROUND:The point-of-care VN-P2Y12 has been used to assess the antiplatelet effects in clopidogrel-treated patients but has not been evaluated in d...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2012.03.022

    authors： Jeong YH,Bliden KP,Antonino MJ,Park KS,Tantry US,Gurbel PA

    更新日期：2012-07-01 00:00:00

  • The favorable clinical and angiographic outcomes of a high-dose dexamethasone-eluting stent: randomized controlled prospective study.

    abstract：BACKGROUND:Previous studies with dexamethasone-eluting stents could not elucidate the role of dexamethasone in the prevention of neointimal hyperplasia because they did not compare their results with a control group. We prospectively evaluated the clinical and angiographic outcomes of dexamethasone-eluting stents, comp...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2006.05.011

    authors： Han SH,Ahn TH,Kang WC,Oh KJ,Chung WJ,Shin MS,Koh KK,Choi IS,Shin EK

    更新日期：2006-11-01 00:00:00

  • The use of intravenous milrinone in chronic symptomatic ischemic heart disease.

    abstract：:To evaluate the antiischemic effects of intravenous milrinone, 20 patients with angiographically proved coronary artery disease and stable angina were studied at rest and during exercise under control conditions and after an intravenous loading injection of milrinone (50 micrograms/kg/10 min) followed by an infusion w...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(91)90835-6

    authors： Mitrovic V,Stöhring R,Schlepper M

    更新日期：1991-06-01 00:00:00

  • The development of cardiac myxomas and papillary endocardial lesions from mural thrombus.

    abstract：:A morphologic study of 466 cardiac mural thrombi, 66 examples of nonbacterial thrombotic endocarditis, 25 myxomas, and 12 papillary endocardial lesions was performed. It appeared that three different sequences of organization of endocardial thrombi are possible. (1) Ordinary mural thrombi are converted into a flat, fi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(75)90003-4

    authors： Salyer WR,Page DL,Hutchins GM

    更新日期：1975-01-01 00:00:00

  • Unsuccessful reperfusion in patients with ST-segment elevation myocardial infarction treated by primary angioplasty.

    abstract：BACKGROUND:Several studies have shown that patency of the epicardial vessel does not guarantee optimal myocardial perfusion in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to identify clinical and angiographic correlates of unsuccessful...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.10.044

    authors： De Luca G,van 't Hof AW,Ottervanger JP,Hoorntje JC,Gosselink AT,Dambrink JH,Zijlstra F,de Boer MJ,Suryapranata H

    更新日期：2005-09-01 00:00:00

  • Cross-sectional echocardiographic spectrum of papillary muscle dysfunction.

    abstract：:Cross-sectional echocardiography identified two abnormal patterns of mitral valve closure in 14 patients with mitral regurgitation due to papillary muscle dysfunction: (1) in three patients with an akinetic inferior-posterior wall but normal cavity size, papillary muscle fibrosis was associated with late systolic mitr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(79)90430-7

    authors： Ogawa S,Hubbard FE,Mardelli TJ,Dreifus LS

    更新日期：1979-03-01 00:00:00

  • Factors associated with development of atrial septal restriction in patients with tricuspid atresia involving the right-sided atrioventricular valve.

    abstract：BACKGROUND:Clinical practice is discrepant regarding routine enlargement of the interatrial communication (IAC) in patients with right-sided atrioventricular valve atresia. We determined the percentage and risk factors of those who develop a restrictive IAC. METHODS:Medical records were reviewed for patients treated f...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.07.037

    authors： Tzifa A,Gauvreau K,Geggel RL

    更新日期：2007-12-01 00:00:00

  • Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.

    abstract：BACKGROUND:Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topi...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ahj.2017.09.013

    authors： Larsson SC,Drca N,Jensen-Urstad M,Wolk A

    更新日期：2018-01-01 00:00:00

  • Long-term efficacy of mexiletine alone and in combination with class Ia antiarrhythmic drugs for refractory ventricular arrhythmias.

    abstract：:The efficacy of mexiletine used alone, and in combination with a class Ia antiarrhythmic drug, was assessed in 159 previously drug-refractory patients with ventricular tachycardia (VT) during serial electrophysiologic studies and during long-term (5-year) clinical follow-up. Electrically-inducible ventricular tachycar...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90482-6

    authors： Whitford EG,McGovern B,Schoenfeld MH,Garan H,Newell JB,McElroy M,Ruskin JN

    更新日期：1988-02-01 00:00:00

  • Impact of cardioversion strategy on functional capacity in patients with atrial fibrillation: the Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) study.

    abstract：BACKGROUND:The ACUTE Trial studied a transesophageal echocardiography (TEE)-guided strategy compared with a conventional strategy for management of patients with atrial fibrillation undergoing direct current cardioversion. The primary aim was to determine if patient functional capacity, measured by the Duke Activity St...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.08.014

    authors： Jasper SE,Lieber EA,Murray RD,Apperson-Hansen C,Black IW,Grimm RA,Pape LA,Klein AL,ACUTE Investigators.

    更新日期：2005-02-01 00:00:00

  • Percutaneous coronary intervention or coronary artery bypass graft surgery for left main coronary artery disease: A meta-analysis of randomized trials.

    abstract：:We aimed to investigate long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) using a meta-analysis from updated published randomized trials. Our data showed that the risk of all-cause death as well as cardi...

    journal_title：American heart journal

    pub_type： 信件,meta分析

    doi：10.1016/j.ahj.2020.06.001

    authors： Kuno T,Ueyama H,Rao SV,Cohen MG,Tamis-Holland JE,Thompson C,Takagi H,Bangalore S

    更新日期：2020-09-01 00:00:00

  • Augmentation of vessel squeezing at coronary-myocardial bridge by nitroglycerin: study by quantitative coronary angiography and intravascular ultrasound.

    abstract：BACKGROUND:Nitroglycerin is known to augment vessel wall squeezing at the site with coronary-myocardial bridging (CMB). This study was designed to define the mechanism of nitroglycerin-induced augmentation of CMB in clinical settings. METHODS:We analyzed nitroglycerin reactivity at the site with CMB in 39 patients. Ma...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70123-7

    authors： Hongo Y,Tada H,Ito K,Yasumura Y,Miyatake K,Yamagishi M

    更新日期：1999-08-01 00:00:00

  • Increasing the yield of ventricular tachycardia induction: a prospective, randomized comparative study of the standard ventricular stimulation protocol to a short-to-long protocol and a new two-site protocol.

    abstract：:Programmed ventricular stimulation with a standard protocol that used up to three extrastimuli was compared prospectively with a short-to-long protocol and a two-site protocol in 77 consecutive patients undergoing electrophysiologic study in an attempt to increase the yield of ventricular tachycardia (VT) induction. T...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(91)90957-j

    authors： Simonson JS,Gang ES,Mandel W,Peter T

    更新日期：1991-01-01 00:00:00

  • The use of the systolic time interval for predicting left ventricular ejection fraction ischemic heart disease.

    abstract：:A large series of 306 patients with ischemic heart disease was studied with automated systolic time intervals and left ventricular ejection fraction as determined by the angiocardiographic method. It was found the pre-ejection period, left ventricular ejection time, delta values, and PEP/LVET ratio all were related to...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(77)80407-9

    authors： Swatzell RH Jr,Bancroft WH Jr,Baldone JC Jr,Tucker MS

    更新日期：1977-04-01 00:00:00

  • The value of stress single photon emission computed tomography in patients without known coronary artery disease presenting with dyspnea.

    abstract：BACKGROUND:Dyspnea is a complex system with multiple etiologies, including myocardial ischemia ("anginal equivalent"). Few studies have examined the utility of stress testing to detect coronary artery disease in this setting. The purpose of this study was to examine the prevalence, severity, and prognostic value of per...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.03.002

    authors： Balaravi B,Miller TD,Hodge DO,Gibbons RJ

    更新日期：2006-09-01 00:00:00

  • Borderline left ventricles in prenatally diagnosed atrioventricular septal defect or double outlet right ventricle: echocardiographic predictors of biventricular repair.

    abstract：BACKGROUND:Atrioventricular septal defect (AVSD) and double outlet right ventricle (DORV) with normally related great arteries and normal ventricular sizes are associated with a good long-term prognosis after biventricular (BV) repair. The outcome of cases with a borderline small left ventricle (bLV) is unclear. The pu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.04.018

    authors： Pitkänen OM,Hornberger LK,Miner SE,Mondal T,Smallhorn JF,Jaeggi E,Nield LE

    更新日期：2006-07-01 00:00:00

  • Successive transradial access for coronary procedures: experience of Quebec Heart-Lung Institute.

    abstract：BACKGROUND:Transradial approach (TRA) for cardiac catheterizations and interventions improves clinical outcomes compared with transfemoral access, and its use is increasing worldwide. However, there are limited data on successive use of same artery for repeat procedures. METHODS:Between May 2010 and May 2011, all cons...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.10.016

    authors： Abdelaal E,Molin P,Plourde G,Machaalany J,Bataille Y,Brousseau-Provencher C,Montminy S,Larose E,Roy L,Gleeton O,Barbeau G,Nguyen CM,Noël B,Costerousse O,Bertrand OF

    更新日期：2013-03-01 00:00:00

  • Ischemia at rest is independent of the extent of ventricular dysfunction and arrhythmias in patients with coronary artery disease.

    abstract：:To assess the relation between myocardial ischemia, ventricular arrhythmias (VA), and left ventricular (LV) dysfunction, we evaluated 74 patients with coronary artery disease (CAD) using radionuclide angiography (to determine the resting ejection fraction [EF]), resting thallium-201 scintigraphy (to ascertain the exte...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90588-5

    authors： Edlin DE,Morganroth J,Iskandrian AS,Speilman SR,Horowitz LN,Kay H

    更新日期：1985-02-01 00:00:00