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Bleeding risk following percutaneous coronary intervention in patients with diabetes prescribed dual anti-platelet therapy.

Abstract：

BACKGROUND:Patients with diabetes mellitus (DM) experience higher rates of in-stent restenosis and greater benefit from drug-eluting stents implant at the time of percutaneous coronary intervention (PCI), necessitating prolonged dual anti-platelet therapy (DAPT). While DAPT reduces risk of ischemic events post-PCI, it also increases risk of bleeding. Whether bleeding rates differ among patients with and without DM, receiving long-term DAPT is unknown. METHODS:Among patients who underwent PCI and were maintained on DAPT for 1 year in a multicenter US registry, we assessed patient-reported bleeding over one year following PCI in patients with and without DM. Multivariable, hierarchical Poisson regression was used to evaluate the association of DM with bleeding during follow-up. RESULTS:Among 2334 PCI patients from 10 US hospitals (mean age 64, 54% ACS), 32.6% had DM. In unadjusted analyses, patients with DM had fewer bleeding events over the year following PCI (DM vs no DM: BARC = 1: 78.0% vs 87.7%, P < .001; BARC ≥2: 4.3% vs 5.3%, P = .33). Following adjustment, patients with (vs without DM) had a lower risk of BARC ≥1 bleeding during follow-up (relative risk [RR] 0.89, 95% CI 0.83-0.96). This decreased bleeding risk persisted after removing bruising from the endpoint definition. CONCLUSIONS:In a real-world PCI registry, patients with DM experienced lower risk of bleeding risk on DAPT. As patients with DM also derive greater ischemic benefit from drug-eluting stents, which requires prolonged DAPT, our findings suggest that the balance between benefit and risk of this therapeutic approach may be even more favorable in patients with DM than previously considered.

journal_name

Am Heart J

journal_title

American heart journal

authors

Grodzinsky A,Arnold SV,Wang TY,Sharma P,Gosch K,Jones PG,Bhatt DL,Steg PG,McGuire DK,Cohen DJ,Spertus JA,Chhatriwalla AK,Lind M,Graham G,Kosiborod M

doi

10.1016/j.ahj.2016.09.010

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

111-118

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(16)30206-X

journal_volume

182

pub_type

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Bleeding risk following percutaneous coronary intervention in patients with diabetes prescribed dual anti-platelet therapy.