Abstract:
:Antiarrhythmic drugs are often more effective in suppressing ventricular tachycardias than are background premature extrasystoles. The mechanism of action of these agents was examined by studies on the effects of lidocaine and quinidine on post-repolarization refractoriness of both basic and premature action potentials. In the absence of antiarrhythmic drugs, the excitability threshold was relatively constant after the end of repolarization of both basic and premature action potentials. In the presence of lidocaine or quinidine, the strength-interval curves were shifted to the right and superiorly, and the two drugs had different effects on the course of the strength-interval curve and Vmax recovery, presumably due to use-dependent V max block. Moreover, depressions of Vmax and excitability were more marked after the premature action potential than after the basic action potential. These results suggest that lidocaine and quinidine cause more depression of the excitability of second premature contractions than of first premature contractions, and also indicate that for protection against sustained ventricular tachycardias, it may not be necessary to suppress chronic premature ventricular contractions.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Nakaya Y,Nii H,Nomura M,Fujino K,Mori Hdoi
10.1016/0002-8703(89)90222-6subject
Has Abstractpub_date
1989-11-01 00:00:00pages
907-12issue
5 Pt 1eissn
0002-8703issn
1097-6744pii
0002-8703(89)90222-6journal_volume
118pub_type
杂志文章abstract:BACKGROUND:Diabetes is associated with a high rate of events after acute coronary syndrome and percutaneous coronary intervention despite aspirin treatment. Once daily aspirin might not provide 24-hour stable biological efficacy in patients with diabetes. We compared the biological efficacy of the same daily dose of as...
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更新日期:2012-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-03-01 00:00:00
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更新日期:2007-11-01 00:00:00
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更新日期:1988-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
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