Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat.

Abstract:

:The antihypertensive effects of the renin inhibitor enalkiren were compared with those of the angiotensin-converting enzyme inhibitor enalaprilat in 17 hypertensive patients (14 white, 3 black; mean age 57 years), whose renin systems had been stimulated by diuretic pretreatment. Patients were studied on 3 separate in-hospital days. On the first study day patients received placebo alone. On day 2 they received intravenous bolus doses of enalkiren (0.03 to 1.0 mg/kg), and on day 3, intravenous bolus doses of enalaprilat (0.625 to 1.25 mg). Each agent reduced systolic (p less than 0.01) and diastolic (p less than 0.01) blood pressure (BP) from baseline levels. The acute decrease in systolic BP of 18.5 +/- 0.4 mm Hg during enalkiren tended to be greater (p less than 0.01) than the decrease of 12.6 +/- 0.7 mm Hg during enalaprilat. Decreases in diastolic BP during enalkiren (11.9 +/- 0.4 mm Hg) were also slightly greater (p less than 0.1) than those during enalaprilat (9.2 +/- 0.4 mm Hg). Based on prestudy plasma renin activity (PRA), patients were divided into "high" renin (PRA greater than 3.5 ng angiotensin l/ml/hr; n = 6) and "low/normal" renin (less than 3.5 ng angiotensin l/ml/hr; n = 11) groups. Reductions in diastolic BP in the "high" renin group during enalkiren (30 +/- 5/20 +/- 3 mm Hg) tended to be greater (p less than 0.07) than those during enalaprilat (23 +/- 7/14 +/- 1 mm Hg); differences were not significant in the "low/normal" group (12 +/- 2/7 +/- 2 and 7 +/- 2/8 +/- 1 mm Hg, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am Heart J

journal_title

American heart journal

authors

Neutel JM,Luther RR,Boger RS,Weber MA

doi

10.1016/0002-8703(91)90477-y

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1094-100

issue

4 Pt 1

eissn

0002-8703

issn

1097-6744

pii

0002-8703(91)90477-Y

journal_volume

122

pub_type

杂志文章
  • Percutaneous transseptal balloon mitral valvuloplasty: the Chinese experience in 30 patients.

    abstract::The results of percutaneous transseptal balloon mitral valvuloplasty (PTBMV) in 30 Chinese patients with rheumatic mitral stenosis are reported. PTBMV with the Inoue balloon catheter was successfully performed in 27 patients without any significant complications. The mean left atrial pressure decreased from 20.15 +/- ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90061-0

    authors: Chen CR,Lo ZX,Huang ZD,Inoue KJ,Cheng TO

    更新日期:1988-05-01 00:00:00

  • Significance of hypotension preceding fatal ventricular tachyarrhythmias in post-coronary obstruction sudden death.

    abstract::While sudden death after acute myocardial infarction or ischemia most commonly occurs in the first few minutes, usually from tachyarrhythmias, little is known of associated hemodynamics. We monitored hemodynamics for 15 minutes following coronary embolization with mercury in 31 awake dogs. In 17 nonsurvivors, mean art...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(81)90131-9

    authors: Franciosa JA,Heckel R

    更新日期:1981-04-01 00:00:00

  • Effect of variability in the interpretation of coronary angiograms on the appropriateness of use of coronary revascularization procedures.

    abstract:BACKGROUND:Evidence from numerous studies of coronary angiography show differences between observers' assessments of 15% to 45%. The implication of this variation is serious: If readings are erroneous, some patients will undergo revascularization procedures unnecessarily and others will be denied an essential treatment...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0002-8703(00)90316-8

    authors: Leape LL,Park RE,Bashore TM,Harrison JK,Davidson CJ,Brook RH

    更新日期:2000-01-01 00:00:00

  • Adherence to practice guidelines: the role of specialty society guidelines.

    abstract:BACKGROUND:Physician adherence to guidelines is often poor, but the reasons have not been completely studied. We investigated whether physician adherence to guidelines for percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) varied by source, development methods, or the exten...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2003.35

    authors: Leape LL,Weissman JS,Schneider EC,Piana RN,Gatsonis C,Epstein AM

    更新日期:2003-01-01 00:00:00

  • Isovolumic relaxation time varies predictably with its time constant and aortic and left atrial pressures: implications for the noninvasive evaluation of ventricular relaxation.

    abstract::The isovolumic relaxation time (IVRT) is an important noninvasive index of left ventricular diastolic function. Despite its widespread use, however, the IVRT has not been related analytically to invasive parameters of ventricular function. Establishing such a relationship would make the IVRT more useful by itself and ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(92)90416-s

    authors: Thomas JD,Flachskampf FA,Chen C,Guererro JL,Picard MH,Levine RA,Weyman AE

    更新日期:1992-11-01 00:00:00

  • Insulin sensitivity in young women with vasovagal syncope.

    abstract:BACKGROUND:Insulin, in addition to its known metabolic effects, has sympatho-excitatory and vasodilatory actions on muscular blood vessels. The goal of this study was to evaluate insulin sensitivity in young women with vasovagal syncope and positive tilt test results (HUT+) and to compare it with that in patients with ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/S0002-8703(02)94707-1

    authors: Ruiz GA,Calvar C,Hermes R,Rivadeneira D,Bengolea V,Chirife R,Tentori MC,Gelpi RJ

    更新日期:2003-05-01 00:00:00

  • Systemic and renal hemodynamic effects of bupicomide: a new vasodilator.

    abstract::The systemic and renal hemodyanmic effects of bupicomide were studied in 10 male patients with uncomplicated essential hypertension of moderate severity. Bupicomide significantly reduced systolic, diastolic, and mean arterial pressure and peripheral vascular resistance and this hypotensive effect was associated with a...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0002-8703(76)80114-7

    authors: Chrysant SG,Adamopoulos P,Tsuchiya M,Frohlich ED

    更新日期:1976-09-01 00:00:00

  • Age and outcome after acute coronary syndromes without persistent ST-segment elevation.

    abstract:BACKGROUND:Although age is the most important variable associated with death among patients with persistent ST-segment elevation, its impact on outcome among patients without persistent ST-segment elevation remains unknown. Moreover, the impact of age on the efficacy of antiplatelet therapy with eptifibatide is unknown...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(00)90018-8

    authors: Hasdai D,Holmes DR Jr,Criger DA,Topol EJ,Califf RM,Harrington RA

    更新日期:2000-05-01 00:00:00

  • Assessment of side branch predilation before a provisional T-stent strategy for bifurcation lesions. A randomized trial.

    abstract:BACKGROUND:A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bi...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2014.05.014

    authors: Pan M,Medina A,Romero M,Ojeda S,Martin P,Suarez de Lezo J,Segura J,Mazuelos F,Novoa J,Suarez de Lezo J

    更新日期:2014-09-01 00:00:00

  • Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure--the REsynchronization reV

    abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) improves symptoms, reduces heart failure (HF)-related hospitalizations, and reverses left ventricular remodeling in some patients with moderate to severe HF and ventricular dyssynchrony defined by a prolonged QRS duration. The effects of CRT on HF outcomes in patients ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2005.03.002

    authors: Linde C,Gold M,Abraham WT,Daubert JC,REVERSE Study Group.

    更新日期:2006-02-01 00:00:00

  • Regional metabolism during coronary occlusion, reperfusion, and reocclusion using phosphorus31 nuclear magnetic resonance spectroscopy in the intact rabbit.

    abstract::Few studies have examined metabolic consequences of coronary occlusion and reperfusion using phosphorus31 nuclear magnetic resonance (31P-NMR) in an intact animal model. Accordingly, we developed a model to study serial changes in myocardial metabolism in the intact open-chest rabbit. Ten animals underwent 20 +/- 2 mi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90656-x

    authors: Kavanaugh KM,Aisen AM,Fechner KP,Chenevert TL,Dunham WR,Buda AJ

    更新日期:1989-01-01 00:00:00

  • Efficacy of intravenous amiodarone as short-term treatment for refractory ventricular tachycardia.

    abstract::The antiarrhythmic efficacy and safety of intravenous amiodarone were evaluated in 13 patients with recurrent sustained ventricular tachycardia. All patients had been refractory to at least three prior antiarrhythmic agents (mean, 3.3 per patient), and 11 had multiple direct current cardioversions. Intravenous amiodar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90523-6

    authors: Klein RC,Machell C,Rushforth N,Standefur J

    更新日期:1988-01-01 00:00:00

  • Coronary angioplasty in symptomatic patients after bypass surgery.

    abstract::With the availability of percutaneous transluminal coronary angioplasty (PTCA), the management of patients who present with recurrent angina following coronary artery bypass surgery (CABG) has changed. From January 1987 to December 1988, 149 symptomatic post CABG patients underwent coronary angiography at our institut...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(90)90121-d

    authors: Tabbalat RA,Haft JI

    更新日期:1990-11-01 00:00:00

  • Transient U wave inversion during variant angina.

    abstract::We studied the prevalence and clinical significance of transient U wave inversion in 43 patients with variant angina. Twenty-four patients (group A) had ST segment elevation in the anterolateral and 19 patients (group B) had this finding in the inferoposterior leads of the ECG during spontaneous angina. In none of the...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90452-6

    authors: Matsuguchi T,Koiwaya Y,Nakagaki O,Takeshita A,Nakamura M

    更新日期:1984-10-01 00:00:00

  • Clinical evaluation of a prospective protocol for the timing of surgery in chronic aortic regurgitation.

    abstract::Out of 160 prospectively followed patients with aortic regurgitation, the clinical courses of 53 patients with pure, severe, and chronic aortic regurgitation and without coronary artery disease who were selected for surgery on the basis of predefined criteria is discussed. Surgical criteria were either unequivocal sym...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(90)90023-q

    authors: Tornos MP,Permanyer-Miralda G,Evangelista A,Worner F,Candell J,Garcia-del-Castillo H,Soler-Soler J

    更新日期:1990-09-01 00:00:00

  • Preconditioning during percutaneous transluminal coronary angioplasty by endogenous and exogenous adenosine.

    abstract:BACKGROUND:The purpose of this study was to assess whether pharmacologic preconditioning by exogenous or endogenous adenosine prevents the deterioration of hemodynamic function and left ventricular performance during percutaneous transluminal coronary angioplasty (PTCA). Ischemic preconditioning renders the heart more ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mhj.2000.110287

    authors: Heidland UE,Heintzen MP,Schwartzkopff B,Strauer BE

    更新日期:2000-11-01 00:00:00

  • Percutaneous coronary intervention or coronary artery bypass graft surgery for left main coronary artery disease: A meta-analysis of randomized trials.

    abstract::We aimed to investigate long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) using a meta-analysis from updated published randomized trials. Our data showed that the risk of all-cause death as well as cardi...

    journal_title:American heart journal

    pub_type: 信件,meta分析

    doi:10.1016/j.ahj.2020.06.001

    authors: Kuno T,Ueyama H,Rao SV,Cohen MG,Tamis-Holland JE,Thompson C,Takagi H,Bangalore S

    更新日期:2020-09-01 00:00:00

  • Statin use in heart failure: a cause for concern?

    abstract:BACKGROUND:Statins are effective in the prevention of coronary events and the treatment of acute coronary syndromes. However, their efficacy and safety in patients with heart failure (HF) are unknown. In this review, we discuss the evidence for the efficacy and safety of statin therapy in patients with HF. METHODS:We ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2005.09.008

    authors: Raina A,Pickering T,Shimbo D

    更新日期:2006-07-01 00:00:00

  • The coronary artery response to implantation of a balloon-expandable flexible stent in the aspirin- and non-aspirin-treated swine model.

    abstract::Intracoronary stents may potentially alleviate some of the problems associated with coronary angioplasty. Since the anatomy and physiology of swine coronary arteries closely resemble those of humans, the response to implantation of the Glanturco-Roubin, balloon-expandable, flexible stent was studied in this model. Add...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90506-d

    authors: Rodgers GP,Minor ST,Robinson K,Cromeens D,Stephens LC,Woolbert SC,Guyton JR,Wright K,Siegel R,Roubin GS

    更新日期:1991-09-01 00:00:00

  • Can heart failure be prevented, delayed, or reversed?

    abstract::A review of the clinical course of chronic heart failure demonstrates that current outcomes remain highly unsatisfactory both in mortality and perhaps more important in morbidity. The extraordinary satisfactory functional responses seen in patients who undergo cardiac transplantation clearly identify the primary cause...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(90)90056-4

    authors: Swan HJ

    更新日期:1990-12-01 00:00:00

  • Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. METHODS:The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclero...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2007.11.018

    authors: Underhill HR,Yuan C,Zhao XQ,Kraiss LW,Parker DL,Saam T,Chu B,Takaya N,Liu F,Polissar NL,Neradilek B,Raichlen JS,Cain VA,Waterton JC,Hamar W,Hatsukami TS

    更新日期:2008-03-01 00:00:00

  • Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr

    abstract:BACKGROUND:Experimental studies suggest that metabolic myocardial support by intravenous (IV) glucose, insulin, and potassium (GIK) reduces ischemia-induced arrhythmias, cardiac arrest, mortality, progression from unstable angina pectoris to acute myocardial infarction (AMI), and myocardial infarction size. However, tr...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2012.02.002

    authors: Selker HP,Beshansky JR,Griffith JL,D'Agostino RB,Massaro JM,Udelson JE,Rashba EJ,Ruthazer R,Sheehan PR,Desvigne-Nickens P,Rosenberg YD,Atkins JM,Sayah AJ,Aufderheide TP,Rackley CE,Opie LH,Lambrew CT,Cobb LA,Macleod BA

    更新日期:2012-03-01 00:00:00

  • Reciprocal rhythm in patients with normal electrocardiogram: Evidence for dual conduction pathways.

    abstract::The present study refers to six patients in whom an A-V reciprocal rhythm could be documented; in four cases it took the form of sustained tachycardia. None of the patients showed any ECG feature of ventricular pre-excitation (PR interval of more than 0.12 sec. and normal QRS configuration). The extrastimulus method s...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(76)80427-9

    authors: Touboul P,Huerta F,Porte J,Delahaye JP

    更新日期:1976-01-01 00:00:00

  • Review of primary prevention trials.

    abstract::The main threat to patients with mild to moderate hypertension is coronary heart disease (CHD), but controlled trials of antihypertensive drug therapy have given disappointing results: overall, the reduction in CHD mortality (11%) and morbidity (10%) were small and nonsignificant. Recent trials comparing a beta blocke...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(87)90602-8

    authors: Rose G

    更新日期:1987-10-01 00:00:00

  • Isosorbide dinitrate and exercise performance in patients with congestive heart failure.

    abstract::Nitrates are widely used for the management of congestive heart failure (CHF), as well as angina pectoris. In both situations, nitrates significantly increase exercise capacity. The mechanism of this beneficial effect is unclear, especially in CHF. Isosorbide dinitrate reduces pulmonary capillary wedge pressure (PCWP)...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(85)90494-6

    authors: Franciosa JA

    更新日期:1985-07-01 00:00:00

  • Hypertension in adults with repaired coarctation of the aorta.

    abstract:AIMS:In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. METHODS AND RESULTS:In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2016.07.012

    authors: Rinnström D,Dellborg M,Thilén U,Sörensson P,Nielsen NE,Christersson C,Johansson B

    更新日期:2016-11-01 00:00:00

  • Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardi

    abstract::Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver for excretion. Impaired cholesterol efflux is associated with higher cardiovascular (CV) event ra...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2020.10.052

    authors: Gibson CM,Kastelein JJP,Phillips AT,Aylward PE,Yee MK,Tendera M,Nicholls SJ,Pocock S,Goodman SG,Alexander JH,Lincoff AM,Bode C,Duffy D,Heise M,Berman G,Mears SJ,Tricoci P,Deckelbaum LI,Steg PG,Ridker P,Mehran R

    更新日期:2021-01-01 00:00:00

  • Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER).

    abstract:BACKGROUND:In the TRACER trial, vorapaxar, a protease-activated receptor-1 antagonist, plus standard care in non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients did not significantly reduce the primary composite end point but reduced a key secondary end point and significantly increased bleeding. Histo...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2014.06.017

    authors: Jones WS,Tricoci P,Huang Z,Moliterno DJ,Harrington RA,Sinnaeve PR,Strony J,Van de Werf F,White HD,Held C,Armstrong PW,Aylward PE,Chen E,Patel MR,Mahaffey KW

    更新日期:2014-10-01 00:00:00

  • Correlations between the spread of ventricular activation and map patterns of measured and difference maps.

    abstract::Three kinds of torso surface isopotential maps (measured, simulated, and difference maps) were delineated at every 1.5 (or 3) msec. during the QRS duration from the 85 unipolar lead ECG's led from the surface of a cylindrical torso model filled with perfusate and containing a canine heart undergoing Langendorff's perf...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:

    authors: Toyoshima H

    更新日期:1976-08-01 00:00:00

  • Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: data from the Heart and Soul study.

    abstract:BACKGROUND:The significance of troponin elevation and clinical utility of troponin testing in ambulatory patients with coronary artery disease (CAD) have not been examined. We sought to investigate the prevalence and prognostic value of cardiac troponin T (cTnT) elevation in a population with stable CAD. METHODS:We st...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2009.07.021

    authors: Hsieh BP,Rogers AM,Na B,Wu AH,Schiller NB,Whooley MA

    更新日期:2009-10-01 00:00:00