Systemic and renal hemodynamic effects of bupicomide: a new vasodilator.

Abstract:

:The systemic and renal hemodyanmic effects of bupicomide were studied in 10 male patients with uncomplicated essential hypertension of moderate severity. Bupicomide significantly reduced systolic, diastolic, and mean arterial pressure and peripheral vascular resistance and this hypotensive effect was associated with a reflexive increase in heart rate, left ventricular ejection rate, and cardiac index; it had no effect upon other reflexive sympathetic adjustments induced by upright tilt and the Valsalva maneuver. Bupicomide also increased renal blood flow and decreased renal vascular resistance, but it had no effect upon the glomerular filtration rate. The hypotensive mechanism of bupicomide therefore is mediated by peripheral arteriolar dilation, through vascular smooth muscle relaxation. The more immediate clinical side effects of bupicomide are related to its strong vasodialting action and include headaches, cutaneous flushing, and tachycardia.

journal_name

Am Heart J

journal_title

American heart journal

authors

Chrysant SG,Adamopoulos P,Tsuchiya M,Frohlich ED

doi

10.1016/s0002-8703(76)80114-7

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

335-9

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(76)80114-7

journal_volume

92

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章,评审

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    更新日期:1978-07-01 00:00:00

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