Abstract:
:There has been considerable debate regarding the value of programmed electrical stimulation in patients who present with asymptomatic, or minimally symptomatic, nonsustained VT. Unfortunately, there has never been a sufficiently large study of an untreated group of patients to make any sense of the issue. We culled the literature for reports published between 1986 and 1990 that met certain minimum requirements, the most important of which were adequate patient profiling and outcome data. The survey identified 12 studies of 926 patients, mean age 61 years, with a 5:1 male preponderance. Underlying heart disease was coronary in 818 patients, including 665 who had experienced previous but not recent myocardial infarctions. Of these, 302 (33%) had inducible sustained ventricular arrhythmias (monomorphic VTs in 264). Eighty-three percent of these patients were treated with antiarrhythmic drugs compared to only 13% of the noninducible group (p less than 0.0001). Sudden death or a sustained arrhythmic event occurred in 54 (18%) of the 302 patients in the inducible group compared with 46 (7%) of the 624 in the noninducible group (p less than 0.001). The sensitivity, specificity, and positive and negative predictive accuracies of the test were 54%, 70%, 18%, and 93%, respectively. Thus a patient with an inducible sustained arrhythmia who manifests nonsustained VT is two and a half times as likely to have a major arrhythmic event, but a negative result bodes well for the patient. However, widespread application of the technique cannot be recommended until these results are confirmed in a large, prospective study in which antiarrhythmic therapy is controlled.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Kowey PR,Taylor JE,Marinchak RA,Rials SJdoi
10.1016/0002-8703(92)90664-hsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
481-5issue
2eissn
0002-8703issn
1097-6744pii
0002-8703(92)90664-Hjournal_volume
123pub_type
杂志文章,meta分析abstract:BACKGROUND:Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO is the final product of a complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates a panel of metabolites involved in...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2021.01.006
更新日期:2021-01-14 00:00:00
abstract::The Magnum/Magnarail system consists of "over-the-wire" balloon catheters and a 0.021 inch (0.53 mm) guide wire with a 1 mm olive-shaped tip. To compare it to conventional systems, 100 consecutive unselected patients with chronic total coronary occlusions were randomly assigned to one of two groups. If the balloon cou...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(92)91020-2
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:The activated coagulation time (ACT) is a rapid measurement of a patient's level of heparin anticoagulation during cardiac catheterization. Patients receiving warfarin therapy occasionally are seen at the catheterization laboratory for emergent procedures. The effects of warfarin on ACT activity have not bee...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70223-6
更新日期:1998-09-01 00:00:00
abstract::Three patients with subpulmonic ventricular septal defect and pulmonary valve fluttering by echocardiography are presented. The echographic changes appear identical to that reported with infundibular pulmonic stenosis and the mechanism causing this fluttering is probably similar. ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(77)80336-0
更新日期:1977-07-01 00:00:00
abstract::The objective of this investigation was to determine the prevalence and clinical associations of systolic anterior motion (SAM) of the mitral chordae (chordal SAM) in patients without evidence of hypertrophic cardiomyopathy. Although SAM of the mitral valve is thought to be a specific marker of hypertrophic obstructiv...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90282-3
更新日期:1996-04-01 00:00:00
abstract::The effects of intravenous adenosine and adenosine triphosphate (ATP) were studied in a double-blind randomized study during 68 episodes of supraventricular tachycardia in 39 patients. Adenosine restored sinus rhythm in 20 patients (25 of 27 episodes) and produced atrioventricular block to reveal atrial arrhythmias in...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-8703(05)80022-5
更新日期:1990-02-01 00:00:00
abstract::Antiplatelet therapy is the current criterion standard for the treatment of patients undergoing percutaneous coronary intervention and patients who have acute coronary syndromes. Clopidogrel in combination with aspirin is the current standard of care for reducing cardiovascular events in these patients. However, patie...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2008.06.003
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Heparin is ubiquitously used in cardiac catheterization but predisposes to the development of heparin-induced thrombocytopenia. The objective was to examine prospectively the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies and heparin-induced thrombocytopenia in the population undergoing cardia...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.04.028
更新日期:2006-08-01 00:00:00
abstract::Pressor response to norepinephrine, cardiopulmonary blood volume, and hemodynamic parameters were studied in 41 borderline hypertensive patients in comparison with 42 permanent essential hypertensive patients and 28 normal subjects. Borderline hypertensive subjects had high cardiac index (p less than 0.0001), normal t...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90155-6
更新日期:1975-04-01 00:00:00
abstract::Intracoronary streptokinase (SK) was administered to 11 patients with evolving acute transmural myocardial infarction 5.5 +/- 0.4 hours from the onset of symptoms. Ten patients (91%) had total coronary occlusion, and one had subocclusion of the vessel corresponding to the ECG site of infarction. Intracoronary nitrogly...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(81)90646-3
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Several studies have shown that patency of the epicardial vessel does not guarantee optimal myocardial perfusion in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to identify clinical and angiographic correlates of unsuccessful...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.10.044
更新日期:2005-09-01 00:00:00
abstract::Of 178 transseptal left heart catheterizations performed, 173 successful cases are reported, with the use of a Swan-Ganz, flow-directed, balloon-tipped catheter. By means of a modified Brockenbrough technique, which is described in detail, a 10F Teflon tube (3.3 mm outside diameter) was inserted into the left atrium. ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(85)90603-9
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Protease inhibitors (PIs) may be associated with accelerated atherosclerosis in individuals infected with human immunodeficiency virus (HIV). We assessed the effects of HIV PIs on subclinical atherosclerosis. METHODS:The lipid profiles, C-reactive protein (CRP) levels, coronary artery calcification (CAC) sc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.125009
更新日期:2002-10-01 00:00:00
abstract::The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90724-1
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:It is unclear whether fibrinogen predicts cardiovascular events independently of echocardiographic cardiovascular abnormalities and traditional risk factors. METHODS:We studied 2671 American Indians who participated in the second Strong Heart Study examination (1993-1995) and were observed for an average of...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.144
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:With one-quarter of initial myocardial infarctions (MI) being unrecognized MI (UMI), recognition is critical to minimize further cardiovascular risk. Diabetes mellitus is an established risk factor for UMI. If impaired fasting glucose (IFG) also increased the risk for UMI, it would represent a significant pu...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2015.08.003
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The pathogenesis of human coronary artery disease (CAD) is likely to require the transcription of many different genes. We report here the differential gene expression profiling of human CAD using copy DNA (cDNA)/nylon array hybridization techniques. METHODS AND RESULTS:Human coronary arteries...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.10.025
更新日期:2005-09-01 00:00:00
abstract::A study of nonbacterial thrombotic endocarditis has been carried out in a series of 3,404 autopsies performed upon atomic bomb survivors in Hiroshima in the period 1953-1970. The prevalence of the lesion was 2.4 per cent, with a greater frequency among the elderly and among females, and with a significant relationship...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90119-2
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS:In hopes of determining temporal trends in PCI outcomes, we used da...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.05.006
更新日期:2013-08-01 00:00:00
abstract::A pilot study was performed to determine the safety and efficacy of coronary pulsed mid-infra-red laser angioplasty. The laser was coupled with a novel 2.0 mm multifiber catheter consisting of 37 optical fibers of 150 microns each arranged concentrically around a 0.018-inch central lumen and a soft leading tapered dis...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(91)91015-f
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Although controversial, reducing low-density lipoprotein cholesterol (LDL-C) to target levels remains a common therapeutic goal after acute myocardial infarction (AMI). We sought to illuminate patient and provider characteristics associated with LDL-C goal nonattainment after AMI. METHODS:In an observationa...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2012.10.005
更新日期:2013-01-01 00:00:00
abstract::The possibility of demonstrating noninvasively with C-11 palmitate and positron emission tomography (PET) changes in myocardial substrate metabolism in normal and diseased human myocardium in response to altered substrate availability in blood and disease-related abnormalities was examined in five normal volunteers an...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90006-2
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Coronary calcium detected noninvasively is an attractive way to diagnose atherosclerosis before the development of symptoms. This study examines the prognostic value of coronary calcium in asymptomatic subjects with usual cardiovascular risk. METHODS AND RESULTS:In 425 asymptomatic subjects, 229 men (aged 4...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.169
更新日期:2003-03-01 00:00:00
abstract::The electrocardiographic QT interval, with a wide variety of practical and theoretic applications in medicine, pharmacology, and cardiology, is critically dependent on heart rate as expressed by cycle length (RR). To account for this and permit intraindividual and interindividual comparisons of changing QT intervals, ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(90)90172-t
更新日期:1990-07-01 00:00:00
abstract::Development of aortic valvular deformities was studied retrospectively in 395 inpatients with subarterial infundibular ventricular septal defect (siVSD). Aortic valvular deformities included prolapse into siVSD without aortic regurgitation (77 patients), prolapse and aortic regurgitation (95 patients), and aneurysm of...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90759-2
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction w...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2012.07.032
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Intramyocardial injection of autologous bone marrow (ABM) may induce angiogenesis. We tested the safety and feasibility of catheter-based direct percutaneous intramyocardial delivery of ABM in patients with refractory angina pectoris. METHODS:Ten patients (9 men, 67 +/- 8 years) with refractory angina (Cana...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.04.033
更新日期:2006-03-01 00:00:00
abstract::An experimental canine model of pericardial effusion was designed to validate previous clinical nuclear magnetic resonance imaging (NMR) studies. Saline (n = 7), serum (n = 4), blood (10% hematocrit [n = 5]; 20% hematocrit [n = 5]), and lipid (n = 4) effusions were chosen to resemble: (1) transudative/exudative, (2) n...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(91)90678-b
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:In recent reports, human toll-like receptor (TLR) 8 mediates the antiviral response by recognizing single-stranded RNA. The inflammatory response against enteroviral (EV) RNA replication may play an important role in dilated cardiomyopathy (DCM). The purpose of this study was to determine whether TLR8 was ex...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.05.010
更新日期:2007-09-01 00:00:00
abstract:AIMS:The impact of estimated glomerular filtration rate (eGFR) on adverse events in patients with mechanical heart valves (MHVs) is unknown. We analyzed the independent association of eGFR and thromboembolism (TE), major bleeding, and mortality in patients with MHV in an observational cohort study. METHODS AND RESULTS...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2015.06.016
更新日期:2015-09-01 00:00:00