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Adenosine or adenosine triphosphate for supraventricular tachycardias? Comparative double-blind randomized study in patients with spontaneous or inducible arrhythmias.

Abstract：

:The effects of intravenous adenosine and adenosine triphosphate (ATP) were studied in a double-blind randomized study during 68 episodes of supraventricular tachycardia in 39 patients. Adenosine restored sinus rhythm in 20 patients (25 of 27 episodes) and produced atrioventricular block to reveal atrial arrhythmias in nine. ATP restored sinus rhythm in 17 patients (22 of 25 episodes) and revealed atrial tachyarrhythmias in six. In patients receiving both compounds, the effective dosage of adenosine was 3.8 mg and of ATP it was 6.6 mg (p less than 0.05), suggesting molar equipotency. Transient side effects were common, occurring in 81% of episodes with adenosine and in 94% with ATP. Symptom scores (0 to 10) were not significantly different (median score for adenosine was 5, for ATP it was 6). Adenosine and ATP were equally effective for the diagnosis and treatment of supraventricular tachycardias and the incidence and severity of side effects were similar. Adenosine has the advantage of being more stable.

journal_name

Am Heart J

journal_title

American heart journal

authors

Rankin AC,Oldroyd KG,Chong E,Dow JW,Rae AP,Cobbe SM

doi

10.1016/s0002-8703(05)80022-5

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

316-23

issue

2 Pt 1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(05)80022-5

journal_volume

119

pub_type

临床试验,杂志文章,随机对照试验

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