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Design of the Trial to Assess Chelation Therapy (TACT).

Abstract：

:TACT is an National Institutes of Health-sponsored, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial testing the benefits and risks of 40 infusions of a multicomponent disodium EDTA chelation solution compared with placebo and of an oral, high-dose multivitamin and mineral supplement. TACT has randomized and will follow up 1,708 patients for an average of approximately 4 years. The primary end point is a composite of all-cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina. A 900-patient substudy will examine quality-of-life outcomes. The trial is designed to have >85% power to detect a 25% relative reduction in the primary end point for each treatment factor. Enrollment began in September 2003 and was completed in October 2010.

journal_name

Am Heart J

journal_title

American heart journal

authors

Lamas GA,Goertz C,Boineau R,Mark DB,Rozema T,Nahin RL,Drisko JA,Lee KL

doi

10.1016/j.ahj.2011.10.002

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

7-12

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(11)00715-0

journal_volume

163

pub_type

杂志文章,随机对照试验

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