Abstract:
BACKGROUND:Cardiac magnetic resonance (cMR) perfusion imaging is a promising technique to assess coronary artery disease (CAD). Our objective was to evaluate accuracy of various cMR imaging parameters to detect significant CAD as compared with angiography or fractional flow reserve (FFR). METHODS:We prospectively enrolled 37 patients who underwent coronary angiography, FFR, and cMR perfusion imaging. Semiquantitative assessments, namely maximum up-slope and peak-intensity indexes, were derived from time-intensity ratios between rest and stress. Myocardial perfusion reserve (MPR), calculated using Fermi deconvolution technique, was the quantitative cMR imaging parameter. Qualitative assessments were visually performed by independent analysts. Accuracy of quantitative, semiquantitative, and qualitative cMR imaging data was compared with quantitative coronary angiography in 108 segments and FFR in 44 segments. RESULTS:Sensitivity and specificity for hemodynamically significant CAD (FFR < or = 0.75) were 92.9% and 56.7%, respectively, for MPR (cutoff, 2.06). Area under the curve to detect FFR < or = 0.75 was 0.78 for MPR (P < .01), 0.63 for up-slope (P = NS), and 0.66 (P = NS) for peak intensity. Sensitivity and specificity for anatomically significant CAD (> 50% diameter stenosis [DS]) were 87.2% and 49.2%, respectively, for MPR (cutoff, 2.06). Area under the curve was 0.75 for MPR, 0.69 for up-slope, and 0.65 for peak intensity to detect > 50% DS (all P < .05). Visual assessment yielded sensitivity of 78.6% and specificity of 65.5% to predict FFR < or = 0.75 and sensitivity of 74.5% and specificity of 67.2% to predict > 50% DS. CONCLUSIONS:Myocardial perfusion reserve appears to be the most accurate index to detect anatomical and hemodynamically significant CAD. Standardization of such quantitative methods, with minimal operator dependency, would be useful for clinical and research applications.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Futamatsu H,Wilke N,Klassen C,Shoemaker S,Angiolillo DJ,Siuciak A,Morikawa-Futamatsu K,Suzuki N,von Ziegler F,Bass TA,Costa MAdoi
10.1016/j.ahj.2007.04.024subject
Has Abstractpub_date
2007-08-01 00:00:00pages
298-305issue
2eissn
0002-8703issn
1097-6744pii
S0002-8703(07)00345-6journal_volume
154pub_type
杂志文章abstract::Patients with diabetes were compared with nondiabetic control subjects, with respect to the prevalence of silent myocardial ischemia, by means of treadmill exercise testing and coronary angiography. Results of treadmill exercise testing showed ischemic ST depression in 41 of the 132 diabetic patients (mean age 61 +/- ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90745-h
更新日期:1992-01-01 00:00:00
abstract::Adverse drug events affect millions of patients each year. An important drug-drug interaction between amiodarone and vitamin K antagonists is encountered frequently in daily clinical practice. Warfarin, a commonly used anticoagulant, is a mixture of 2 optically active isomers (R and S enantiomers). The S enantiomer is...
journal_title:American heart journal
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
abstract::Transient U wave inversion can be caused either by regional myocardial ischemia or by an elevation of systemic blood pressure. The characteristics of U wave inversion during chest pain attacks in 21 patients with variant angina were compared with those observed in 38 patients with hypertension without apparent ischemi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90104-h
更新日期:1993-04-01 00:00:00
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doi:10.1016/j.ahj.2012.07.032
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The ODYSSEY COMBO I study (http://clinicaltrials.gov/show/NCT01644175) evaluated efficacy and safety of alirocumab as add-on therapy to stable maximally tolerated daily statin with or without other lipid-lowering therapy in high cardiovascular risk patients with suboptimally controlled hypercholesterolemia. ...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2015.03.004
更新日期:2015-06-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.10.002
更新日期:2006-01-01 00:00:00
abstract::Exercise-induced changes in QRS duration were assessed in 25 normal subjects and in 17 patients with stable ischemic heart disease. None had bundle branch block or were taking medications, and all patients had angina pectoris induced during the test. QRS duration and ST60 amplitude were measured by computer during res...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90640-x
更新日期:1986-05-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90272-0
更新日期:1996-04-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.112487
更新日期:2001-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2007.10.003
更新日期:2008-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90404-j
更新日期:1992-11-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90175-9
更新日期:1993-03-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80313-8
更新日期:1990-04-01 00:00:00
abstract::This study was designed to evaluate the relative diagnostic values of transthoracic (TTE) and transesophageal (TEE) echocardiography in the assessment of congenitally corrected transposition of the great arteries in adult patients. Twelve patients (mean age 29 years, range 21 to 39 years) with congenitally corrected t...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0002-8703(98)70341-2
更新日期:1998-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90462-7
更新日期:1996-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2020.01.008
更新日期:2020-04-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90564-8
更新日期:1986-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2016.03.003
更新日期:2016-06-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2017.08.012
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2010.09.025
更新日期:2011-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.06.013
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.03.040
更新日期:2004-10-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1990-09-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.06.025
更新日期:2007-09-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2021-01-01 00:00:00