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Dronedarone and vitamin K antagonists: a review of drug-drug interactions.

Abstract：

:Adverse drug events affect millions of patients each year. An important drug-drug interaction between amiodarone and vitamin K antagonists is encountered frequently in daily clinical practice. Warfarin, a commonly used anticoagulant, is a mixture of 2 optically active isomers (R and S enantiomers). The S enantiomer is approximately 3 times more potent than the R enantiomer and is metabolized primarily by CYP2C9. Inhibition of CYP2C9 by amiodarone and its major metabolite potentiates the anticoagulant effects of warfarin, increasing the risk of serious bleeding. In contrast, dronedarone, a synthetic derivative of amiodarone the structure of which lacks the iodine moiety, is less likely to cause a drug-drug interaction with warfarin. Accordingly, dronedarone may be a particularly attractive antiarrhythmic choice among patients with atrial fibrillation who are also being treated with warfarin.

journal_name

Am Heart J

journal_title

American heart journal

authors

Shirolkar SC,Fiuzat M,Becker RC

doi

10.1016/j.ahj.2010.07.008

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

577-82

issue

4

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00575-2

journal_volume

160

pub_type

杂志文章,评审

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