Sudden cardiac death: the role of risk stratification.

Abstract:

:Sudden cardiac death syndrome remains a major health problem responsible for approximately 400,000 deaths annually in the US. Effective therapies exist but are costly and are associated with potential complications. Currently used strategies for selection of the best candidates for implantable cardioverter defibrillator (ICD) therapy are imperfect and leave a large number of high-risk patients unprotected. At the same time, many patients who received ICDs will never develop tachyarrhythmia and require ICD intervention. The article summarizes the current status and applicability of the noninvasive and invasive tests used for sudden cardiac death risk assessment with the emphasis on the increasingly recognized value of microvolt T wave alternans.

journal_name

Am Heart J

journal_title

American heart journal

authors

Kusmirek SL,Gold MR

doi

10.1016/j.ahj.2007.01.024

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

25-33

issue

4 Suppl

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(07)00083-X

journal_volume

153

pub_type

杂志文章,评审
  • INtensive versus standard ambulatory blood pressure lowering to prevent functional DeclINe in the ElderlY (INFINITY).

    abstract::Reductions in mobility and cognitive function linked to accrual of brain microvascular disease related white matter hyperintensities (WMHs) on magnetic resonance imaging can occur in older hypertensive patients in as little as 2 years. We have designed a trial evaluating 2 levels of ambulatory blood pressure (ABP) con...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2012.11.008

    authors: White WB,Marfatia R,Schmidt J,Wakefield DB,Kaplan RF,Bohannon RW,Hall CB,Guttmann CR,Moscufo N,Fellows D,Wolfson L

    更新日期:2013-03-01 00:00:00

  • Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy.

    abstract:BACKGROUND:The left atrium is afterload sensitive, responding to immediate changes in left ventricular (LV) diastolic pressure, and left atrial volumetric remodeling has been reported in conditions associated with abnormal diastolic function. We examined the relationship between left atrial volumetric remodeling and ob...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.07.017

    authors: Sachdev V,Shizukuda Y,Brenneman CL,Birdsall CW,Waclawiw MA,Arai AE,Mohiddin SA,Tripodi D,Fananapazir L,Plehn JF

    更新日期:2005-04-01 00:00:00

  • Neurosurgical evacuation of intracranial hemorrhage after thrombolytic therapy for acute myocardial infarction: experience from the GUSTO-I trial. Global Utilization of Streptokinase and tissue-plasminogen activator (tPA) for Occluded Coronary Arteries.

    abstract:BACKGROUND:Intracranial hemorrhage is an uncommon but very dangerous complication in patients receiving thrombolytic therapy for acute myocardial infarction. Neurosurgical evacuation is often an available treatment option. However, the association between neurosurgical evacuation and clinical outcomes in these patients...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(99)70152-3

    authors: Mahaffey KW,Granger CB,Sloan MA,Green CL,Gore JM,Weaver WD,White HD,Simoons ML,Barbash GI,Topol EJ,Califf RM

    更新日期:1999-09-01 00:00:00

  • A randomized controlled trial of low-dose hormone therapy on myocardial ischemia in postmenopausal women with no obstructive coronary artery disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-sponsored Women'

    abstract:BACKGROUND:Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-d...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2010.03.024

    authors: Merz CN,Olson MB,McClure C,Yang YC,Symons J,Sopko G,Kelsey SF,Handberg E,Johnson BD,Cooper-DeHoff RM,Sharaf B,Rogers WJ,Pepine CJ

    更新日期:2010-06-01 00:00:00

  • Prediabetes and the association with unrecognized myocardial infarction in the multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND:With one-quarter of initial myocardial infarctions (MI) being unrecognized MI (UMI), recognition is critical to minimize further cardiovascular risk. Diabetes mellitus is an established risk factor for UMI. If impaired fasting glucose (IFG) also increased the risk for UMI, it would represent a significant pu...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2015.08.003

    authors: Stacey RB,Leaverton PE,Schocken DD,Peregoy JA,Bertoni AG

    更新日期:2015-11-01 00:00:00

  • Recovery kinetics of oxygen uptake is prolonged in adults with an atrial septal defect and improves after transcatheter closure.

    abstract:BACKGROUND:In adults with an atrial septal defect (ASD) transcatheter closure leads to an improvement of peak oxygen uptake (VO2), but the kinetics of recovery of VO2 after maximal exercise in this patient population and the impact of transcatheter ASD closure have never been investigated. METHODS:Twenty consecutive p...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2003.11.013

    authors: Giardini A,Donti A,Specchia S,Coutsoumbas G,Formigari R,Prandstraller D,Bronzetti G,Bonvicini M,Picchio FM

    更新日期:2004-05-01 00:00:00

  • Diabetes status and racial differences in post-myocardial infarction mortality.

    abstract:BACKGROUND:Prior studies regarding the effect of racial status on post-myocardial infarction (MI) in subjects with diabetes have yielded conflicting results. We evaluated the effect of diabetes status on racial differences in post-MI mortality and morbidity for a 7-year period, from 1990 through 1997. METHODS:All pati...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2005.02.042

    authors: Kamalesh M,Subramanian U,Ariana A,Sawada S,Peterson E

    更新日期:2005-11-01 00:00:00

  • Automatic adjustment of pacing output in the clinical setting.

    abstract:BACKGROUND:AutoCapture (AC) is a programmable feature that enables the pacemaker to both track the capture threshold and automatically adjust the output on a beat-by-beat basis. Although AC safely and significantly reduces the current drainage, some authors have argued that the longevity benefit of such a system is ove...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(03)00529-5

    authors: Ribeiro AL,Rincón LG,Oliveira BG,Vinha CR,Melatto D,Torres AA,Barros VC,Levine PA

    更新日期:2004-01-01 00:00:00

  • Amplitude of the first heart sound at rest and during exercise in normal subjects and in patients with coronary heart disease.

    abstract::The response of S1 amplitude to exercise stress was investigated in patients with coronary heart disease. Phonocardiograms were recorded at rest and during a multistage bicycle ergometer exercise test in a group of 22 patients with angina pectoris and documented coronary disease, and in a normal control group comprise...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(75)90461-5

    authors: Bergman ST Jr,Blomqvist CG

    更新日期:1975-12-01 00:00:00

  • Expanding the outcomes in clinical trials of heart failure: the quality of life and economic components of EPHESUS (EPlerenone's neuroHormonal Efficacy and SUrvival Study).

    abstract:BACKGROUND:Although quantification of the impact of treatment on survival remains the cornerstone of clinical research, the assessment of a broader range of disease outcomes is growing increasingly important. This manuscript provides an overview of the considerations made regarding quantification of a range of clinical...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1067/mhj.2002.120775

    authors: Spertus JA,Tooley J,Jones P,Poston C,Mahoney E,Deedwania P,Hurley S,Pitt B,Weintraub WS

    更新日期:2002-04-01 00:00:00

  • Quantitative assessment of temporal and spatial ventricular wall motion in normal and infarcted human left ventricles.

    abstract::A new integrated method for quantitating temporal and spatial systolic wall motion heterogeneity was developed and applied in 15 normal subjects and 26 patients with previous myocardial infarction (MI). After frame by frame digitizing, right anterior oblique left cineventriculograms (LV) were analyzed with 90 spaced r...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90465-5

    authors: Chen CG,Bonzel T,Just H,Seiffert G,Zeiher A,Kasper W,Wollschlaeger H

    更新日期:1986-10-01 00:00:00

  • Metabolic syndrome and coronary angiographic disease progression: the Women's Angiographic Vitamin & Estrogen trial.

    abstract:BACKGROUND:The metabolic syndrome is a cluster of clinical characteristics thought to be associated with increased coronary risk. This analysis evaluates angiographic progression of coronary disease in women who are postmenopausal with and without the metabolic syndrome enrolled in the Women's Angiographic Vitamin & Es...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/S0002-8703(03)00227-8

    authors: Hsia J,Bittner V,Tripputi M,Howard BV

    更新日期:2003-09-01 00:00:00

  • Prognostic implications of complicated ventricular arrhythmias early after hospital discharge in acute myocardial infarction: a serial ambulatory electrocardiography study.

    abstract::To assess the prevalence and prognostic implications of complicated ventricular ectopic depolarizations (VEDs) after hospital discharge in patients with acute myocardial infarction (AMI), we obtained serial 24-hour Holter recordings in 85 patients during the first 6 weeks after AMI. Recordings were obtained during two...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90745-2

    authors: Olson HG,Lyons KP,Troop P,Butman SM,Piters KM

    更新日期:1984-11-01 00:00:00

  • Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery.

    abstract:BACKGROUND:Elevations of creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT) have an uncertain long-term prognostic value after coronary artery bypass graft (CABG) surgery. We aimed to test the hypothesis that CK-MB and cTnT are predictors of long-term survival after CABG and to assess which of these 2 biomarkers ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2012.05.027

    authors: Søraas CL,Friis C,Engebretsen KV,Sandvik L,Kjeldsen SE,Tønnessen T

    更新日期:2012-11-01 00:00:00

  • Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study.

    abstract:BACKGROUND:Chest pain in the absence of obstructive coronary artery disease (CAD) is common in women; it is frequently associated with debilitating symptoms and repeated evaluations and may be caused by coronary microvascular dysfunction. However, the prevalence and determinants of microvascular dysfunction in these wo...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.114198

    authors: Reis SE,Holubkov R,Conrad Smith AJ,Kelsey SF,Sharaf BL,Reichek N,Rogers WJ,Merz CN,Sopko G,Pepine CJ,WISE Investigators.

    更新日期:2001-05-01 00:00:00

  • Myocardial reperfusion injury in the canine model after 40 minutes of ischemia: effect of intracoronary adenosine.

    abstract::To explore the contribution of reperfusion injury to final infarct size after a short duration of ischemia, closed-chest dogs underwent 40 minutes of proximal left anterior descending artery occlusion followed by 3 days of reperfusion. Animals randomly received intracoronary adenosine (n = 8) at 3.75 mg/min during the...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90272-j

    authors: Velasco CE,Turner M,Cobb MA,Virmani R,Forman MB

    更新日期:1991-12-01 00:00:00

  • Comparison of a new 3-item self-reported measure of adherence to medication with pharmacy claims data in patients with cardiometabolic disease.

    abstract:BACKGROUND:Less than half of patients with cardiometabolic disease consistently take prescribed medications. While health insurers and some delivery organizations use claims to measure adherence, most clinicians do not have access during routine interactions. Self-reported scales exist, but their practical utility is o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2020.06.012

    authors: Lauffenburger JC,Fontanet CP,Isaac T,Gopalakrishnan C,Sequist TD,Gagne JJ,Jackevicius CA,Fischer MA,Solomon DH,Choudhry NK

    更新日期:2020-10-01 00:00:00

  • Diagnostic value of 12-lead electrocardiogram during dobutamine echocardiographic studies.

    abstract:BACKGROUND:The diagnostic value of 12-lead electrocardiography during dobutamine stress echocardiography (DSE) is not well documented. METHODS AND RESULTS:We reviewed the records of 116 patients referred for DSE and coronary angiography, 52 of whom were excluded because of abnormal ST segment or inadequate DSE. Of the...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70163-2

    authors: Shaheen J,Luria D,Klutstein MW,Rosenmann D,Tzivoni D

    更新日期:1998-12-01 00:00:00

  • Electrocardiographic presentation of blacks with first myocardial infarction does not explain race differences in thrombolysis administration.

    abstract:BACKGROUND:Previous studies have suggested that thrombolysis is used less often in blacks than in whites. However, whether the greater prevalence of contraindications or less specific electrocardiographic manifestations of myocardial infarction (MI) account for this difference is unclear. METHODS AND RESULTS:We studie...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.107173

    authors: Manhapra A,Khaja F,Syed M,Rybicki BA,Wulbrecht N,Alam M,Sabbah H,Goldstein S,Borzak S

    更新日期:2000-08-01 00:00:00

  • In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: A double-blind randomized study from the National Hea

    abstract:BACKGROUND:We investigated the role of the renin-angiotensin system in women with signs and symptoms of ischemia without obstructive coronary artery disease (CAD). Although microvascular dysfunction has been suggested to explain this syndrome and recently was found to predict adverse outcomes, the mechanisms and treatm...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2011.07.011

    authors: Pauly DF,Johnson BD,Anderson RD,Handberg EM,Smith KM,Cooper-DeHoff RM,Sopko G,Sharaf BM,Kelsey SF,Merz CN,Pepine CJ

    更新日期:2011-10-01 00:00:00

  • The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

    abstract:BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.04.003

    authors: de Groote P,Lamblin N,Helbecque N,Mouquet F,Hermant X,Amouyel P,Dallongeville J,Bauters C

    更新日期:2006-10-01 00:00:00

  • Epidemiologic study of use of resources in patients with unstable angina: the EARISA registry. On behalf on the EARISA Investigators (Epidemiologia dell'Assorbimento di Risorse nell'Ischemia, Scompenso e Angina).

    abstract:AIM:The EARISA Registry was designed to describe diagnostic and therapeutic resources used in Italian cardiology centers for patients with the epidemiologically most relevant cardiac diseases. This article focuses on patients with unstable angina; characteristics associated with invasive procedures were specifically an...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.107997

    authors: Maggioni AP,Schweiger C,Tavazzi L,Langiano T,Lucci D,Ramponi C,Repetto F,De Vita C

    更新日期:2000-08-01 00:00:00

  • Correlation of abnormal Q waves, coronary pathology, and ventricular contractility.

    abstract::Four hundred and ninety-two patients with coronary artery disease underwent analysis of their electrocardiograms, coronary arteriograms, and ventriculograms. Significant Q-waves were correlated with critical coronary occlusions (greater than or equal 75 per cent obstruction) and ventricular contractility. It was found...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(75)90425-1

    authors: Gottlieb RS,Duca PR,Kasparian H,Scariato A,Brest AN

    更新日期:1975-10-01 00:00:00

  • Neopterin levels in patients with coronary artery disease are independent of Chlamydia pneumoniae seropositivity.

    abstract:BACKGROUND:Chronic infection with Chlamydia pneumoniae (Cpn) has been associated with atherosclerotic cardiovascular disease in sero-epidemiological, pathological and animal-model studies. Inflammation and immune activation has been proposed as the pathophysiological link between chronic infection and atherosclerosis. ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/S0002-8703(03)00101-7

    authors: Smith DA,Zouridakis EG,Mariani M,Fredericks S,Cole D,Kaski JC

    更新日期:2003-07-01 00:00:00

  • Correlates of prolonged HV conduction in aortic stenosis.

    abstract::Forty-eight patients with predominant aortic stenosis underwent His bundle electrography (HBE) at the time of diagnostic catheterization. Patients were divided into four groups based upon severity of calcification of the aortic valve fluoroscopically as judged independently by three angiographers. Of 48 patients, thre...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90514-9

    authors: MacMillan RM,Demorizi NM,Gessman LJ,Maranhao V

    更新日期:1985-07-01 00:00:00

  • Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress.

    abstract:BACKGROUND:Procoagulant stress responses may contribute to atherosclerosis development and acute coronary thrombosis. In the present study, we examined the role of beta2-adrenergic receptor function and plasma catecholamines in the stress-induced increase in the 2 hypercoagulability markers thrombin-antithrombin III (T...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2002.123146

    authors: von Känel R,Mills PJ,Ziegler MG,Dimsdale JE

    更新日期:2002-07-01 00:00:00

  • Temporal changes in emergency department triage of patients with acute myocardial infarction and the effect on outcomes.

    abstract:BACKGROUND:All patients who present to an emergency department (ED) are triaged. The ED triage score may determine when patients are seen by a physician. Half of patients with acute myocardial infarction (AMI) were given a low priority score in Ontario in 2000/2001. We assessed the appropriateness of ED triage and its ...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2011.05.015

    authors: Atzema CL,Schull MJ,Austin PC,Tu JV

    更新日期:2011-09-01 00:00:00

  • A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

    abstract:BACKGROUND:The aim of this study was to compare rate of onset, magnitude, and consistency of platelet inhibition after administration of prasugrel or clopidogrel and to relate platelet inhibition to systemic exposure to each active metabolite. Thienopyridines are prodrugs, metabolized in vivo to active metabolites that...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2006.10.010

    authors: Brandt JT,Payne CD,Wiviott SD,Weerakkody G,Farid NA,Small DS,Jakubowski JA,Naganuma H,Winters KJ

    更新日期:2007-01-01 00:00:00

  • Perioperative beta-blocker withdrawal and mortality in vascular surgical patients.

    abstract:OBJECTIVE:Our purpose was to determine the effect of postoperative beta-blocker withdrawal on mortality and cardiovascular events after vascular surgery. METHODS:Detailed data were collected on perioperative cardiovascular medication use and discontinuation and cardiovascular risk factors among consecutive major vascu...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.111547

    authors: Shammash JB,Trost JC,Gold JM,Berlin JA,Golden MA,Kimmel SE

    更新日期:2001-01-01 00:00:00

  • Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program.

    abstract:BACKGROUND:Cohort studies have suggested little effect of coffee consumption on risk of acute myocardial infarction. The effect of coffee consumption on prognosis after myocardial infarction is uncertain. METHODS:In a population-based inception cohort study, we followed 1,369 patients hospitalized with a confirmed fir...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.11.009

    authors: Mukamal KJ,Hallqvist J,Hammar N,Ljung R,Gémes K,Ahlbom A,Ahnve S,Janszky I

    更新日期:2009-03-01 00:00:00