Abstract:
BACKGROUND:In adults with an atrial septal defect (ASD) transcatheter closure leads to an improvement of peak oxygen uptake (VO2), but the kinetics of recovery of VO2 after maximal exercise in this patient population and the impact of transcatheter ASD closure have never been investigated. METHODS:Twenty consecutive patients underwent a maximal cardiopulmonary exercise test both the day before and 6 months after transcatheter ASD closure. For comparison, an age- and sex-matched group consisting of 53 healthy adults was built. The constant decay of VO2, CO2 production (VCO2), minute ventilation (VE), and heart rate (HR), expressed as the first-degree slope of a single linear relation, were calculated for the first minute of recovery. RESULTS:Patients with an ASD had a prolonged VO2 slope (P =.0012), VCO2 slope (P =.0003), and VE slope (0.013) when compared with control subjects. Six months after transcatheter ASD closure, significant improvements of VO2 slope (P =.0043) and of VCO2 slope (P =.0022) were recorded, so that no difference was found when compared with those of the control group (P =.1 and P =.06, respectively). The VE slope and HR slope did not change after closure. A significant association between VO2 slope and peak VO2 in the group of patients with ASD was shown by the Spearman correlation, both before (r = 0.67, P =.0012) and after ASD closure (r = 0.71, P =.0004). CONCLUSIONS:A limited cardiopulmonary reserve in adults with no symptom who have an ASD appears to affect not only maximal exercise responses but also the recovery phase. Transcatheter ASD closure induces a significant improvement of the ability of recovering from maximal exercise and eliminates the difference with a healthy population.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Giardini A,Donti A,Specchia S,Coutsoumbas G,Formigari R,Prandstraller D,Bronzetti G,Bonvicini M,Picchio FMdoi
10.1016/j.ahj.2003.11.013subject
Has Abstractpub_date
2004-05-01 00:00:00pages
910-4issue
5eissn
0002-8703issn
1097-6744pii
S0002870303008263journal_volume
147pub_type
杂志文章abstract:BACKGROUND:The major structural characteristic of congestive heart failure is myocardial cell death. The aim of our study was to determine whether the level of cardiac troponin T, a protein specific for cardiac necrosis, was increased in patients with congestive heart failure. METHODS AND RESULTS:Plasma samples were o...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(99)70252-8
更新日期:1999-07-01 00:00:00
abstract::Evaluation of pericardial effusion was attempted with computed tomography in 11 patients. The volume and distribution of pericardial fluid were assessed with satisfactory resolution and the nature of the fluid was estimated by the difference in x-ray transparency (CT numbers). The volume of pericardial fluid calculate...
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更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(92)90593-k
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pub_type: 杂志文章,meta分析
doi:10.1016/j.ahj.2006.11.020
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abstract::The purpose of this study was to compare the three most commonly used maximal graded exercise test (GXT) protocols in healthy women. Submaximal and maximal metabolic and hemodynamic responses were determined from two treadmill protocols, Bruce and Balke, and a bicycle protocol, in 49 women. Maximum oxygen uptake (VO2 ...
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2005.07.033
更新日期:2006-04-01 00:00:00
abstract::Inducible ventricular tachycardia frequently persists despite solitary class I antiarrhythmic drug therapy. To determine the effect of metoprolol as adjuvant therapy, 19 patients with clinical ventricular tachycardia with baseline inducible sustained monomorphic ventricular tachycardia and persistently inducible ventr...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90270-6
更新日期:1992-09-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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journal_title:American heart journal
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0002-8703(90)90194-3
更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
doi:10.1016/0002-8703(95)90318-6
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2009.05.030
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(91)90713-r
更新日期:1991-02-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-04-01 00:00:00
abstract::In 30 years of follow-up in the Framingham study, routine biennial ECG examinations revealed 315 subjects with ECG-LVH and 164 with unrecognized ECG-MI without previous cardiac explanation. Among subjects initially free of clinically evident coronary heart disease and both ECG abnormalities, the incidence of ECG-LVH w...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-09-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/S0002-8703(03)00411-3
更新日期:2003-12-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-05-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1067/mhj.2003.32
更新日期:2003-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.119616
更新日期:2002-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(78)90471-4
更新日期:1978-02-01 00:00:00
abstract::The presence and severity of functional mitral regurgitation were quantified by Doppler echocardiography in 17 patients with dilated cardiomyopathy and no evidence of primary valvular disease. Mitral regurgitant fraction was greater than 20% in 11 of the 17 patients, and exceeded 40% in four patients. Total stroke vol...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(88)90334-1
更新日期:1988-09-01 00:00:00