Drug interactions with amiodarone.

Abstract:

:There are a number of important drug interactions with amiodarone. This agent appears to have a marked effect on the kinetics of some commonly used cardiovascular drugs, such as warfarin, digoxin, quinidine, and procainamide, and has dynamic interactions with others, such as the beta blockers and some calcium antagonists. Bleeding has been reported, apparently caused by a potentiation of the anticoagulant effect of warfarin by amiodarone. Torsades de pointes has been observed when quinidine, propafenone, or mexiletine is given together with amiodarone. Furthermore, amiodarone may interact with beta-blocking agents and some of the calcium antagonists to produce symptomatic sinus bradycardia and sinus arrest, especially in a latent or overt sick sinus syndrome. During surgery, amiodarone may induce hypotension and an atropine-resistant bradycardia, possibly by interacting with anesthetic agents. A knowledge of the time of onset, extent, duration, and possible mechanisms of the interactions of amiodarone with other cardioactive drugs is still incomplete, but further studies are of great therapeutic importance.

journal_name

Am Heart J

journal_title

American heart journal

authors

Marcus FI

doi

10.1016/0002-8703(83)90017-0

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

924-30

issue

4 Pt 2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(83)90017-0

journal_volume

106

pub_type

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