Abstract:
:The aim of this study was to investigate whether platelet-activating factor (PAF), PAF receptors, and PAF receptor-mediated effects in the human myocardium play a role in cardiac depression during anaphylaxis or septic shock. The effects of PAF, the biologically inactive derivative lyso-PAF, and the specific PAF antagonist WEB 2086 were studied in human myocardial tissue, in human coronary arteries, in human platelets, and in human lung tissue. PAF (C16-PAF, C18-PAF; 0.000001 to 1 mumol/L) had no effect on isometric force of contraction of electrically driven right atrial trabeculae (patients undergoing aortocoronary bypass surgery) and left ventricular papillary muscle strips (mitral valve replacement). PAF (0.2 mumol/L) did not influence the concentration-response curve of either the beta-adrenoceptor agonist isoprenaline (ISO, 0.0001 to 1 mumol/L) or the m-cholinoceptor agonist carbachol (CARB, 0.0001 to 10 mumol/L). The effectiveness (ISO +4.7 +/- 0.7 mN, PAF + ISO + 4.3 +/- 0.44 mN, CARB -2.7 +/- 1.06 mN; PAF + CARB -2.6 +/- 0.52 mN) and the potency--as indicated by the EC50 values--of both isoprenaline and carbachol were identical with and without pretreatment with PAF (0.2 mumol/L). PAF at concentrations of 0.000001 to 10 mumol/L exerted no effect on force of contraction either precontracted (prostaglandin F2 alpha, 0.3 mumol/L) or unprecontracted in human coronary artery rings. Histamine (0.01 to 100 mumol/L) and noradrenaline (0.001 to 30 mumol/L) initiated concentration-dependent contraction in human coronary artery rings (EC50: histamine, 1.86 mumol/L; noradrenaline, 0.69 mumol/L). At lower concentrations (PAF, 0.01 mumol/L) PAF produced complete aggregation of human platelets. In human platelet membranes and lung membranes, 3H-WEB 2086 exhibited saturable high-affinity binding (KD 14.4 nmol/L and 14.3 nmol/L). The maximal binding capacity was 292 fmol/mg protein and 268 fmol/mg protein, respectively. In displacement experiments PAF (0.01 to 10000 nmol/L) and WEB 2086 (0.01 to 10000 nmol/L), but not lyso-PAF, completely displaced 3H-WEB 2086 from its binding sites on human and lung membranes. In contrast, neither in left ventricular membranes nor in right atrial membranes was specific binding of 3H-WEB 2086 observed. These results suggest that there are neither specific PAF receptors nor direct PAF-mediated actions in human myocardial tissue or human coronary artery rings. The effects of PAF on myocardial function may be due to the activation of mediators (e.g., histamine).
journal_name
Am Heart Jjournal_title
American heart journalauthors
Schwinger RH,Böhm M,La Rosée K,Erdmann Edoi
10.1016/0002-8703(92)90593-ksubject
Has Abstractpub_date
1992-08-01 00:00:00pages
320-30issue
2eissn
0002-8703issn
1097-6744pii
0002-8703(92)90593-Kjournal_volume
124pub_type
杂志文章abstract::A pair of endocardial pacemaker leads, identical except for the presence or absence of dexamethasone elution from the distal stimulating electrode, was implanted into the right ventricle of each of 12 dogs for either 3 weeks (n = six pairs) or 6 weeks (n = six pairs). Fibrous connective tissue sheaths (0.04 to 0.20 mm...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90408-0
更新日期:1989-06-01 00:00:00
abstract::The Lown grading system uses three levels of frequency and four complex features to grade ventricular arrhythmias. The seven Lown grades are mutually exclusive (a patient can be in only one grade) and hierarchical (higher grades indicate increased likelihood of death). We evaluated the ability of the Lown arrhythmia g...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90217-3
更新日期:1980-12-01 00:00:00
abstract::A retrospective analysis of our experience with intraprocedural thrombus complicating percutaneous transluminal coronary angioplasty (PTCA) was undertaken. Of 983 PTCA procedures reviewed, 62 (6.3%) were complicated by thrombus. Patients were managed conservatively (group I, n = 18), with redilation (group II, n = 17)...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90912-f
更新日期:1992-07-01 00:00:00
abstract::Three illustrative cases of refractory hypoxemia in adults are presented. In two cases contrast echocardiography was invaluable in establishing the diagnosis of a true anatomic right to left shunt, as well as in localizing the shunt to an intracardiac or extracardiac site. In the third case true anatomic right to left...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90126-t
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is one of the leading causes of morbidity and mortality among Americans. Despite increased interest in end-of-life care, the implications of do-not-resuscitate (DNR) orders in acutely ill patients with HF remain unclear. The goals of this observational study were to describe the use of DNR...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.01.030
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Peak oxygen consumption is a cornerstone for prognostic determination in patients with congestive heart failure. The purpose of this study was to assess whether plasma B-type natriuretic peptide (BNP) provided any additional prognostic information. METHODS:Plasma concentrations of atrial natriuretic peptide...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00365-X
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Prescribing rate control medications with or without antiarrhythmic drugs is often the first course treatment for atrial fibrillation (AF). Clinical trial data suggest that antiarrhythmic drugs are only marginally effective and have multiple drawbacks, whereas rate control alone is sufficient for most patien...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2014.03.024
更新日期:2014-07-01 00:00:00
abstract::Chronic exposure to fine particulate matter (PM2.5) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of th...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2017.11.007
更新日期:2018-03-01 00:00:00
abstract::The effects of atrial pacing on the signal-averaged electrocardiogram were studied in 14 patients with remote myocardial infarction and a history of cardiac arrest or sustained ventricular tachycardia (group I) and in 13 patients with coronary artery disease and no history of sustained ventricular tachyarrhythmia (gro...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80077-8
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. METHODS:Using the Get W...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2019.01.006
更新日期:2019-05-01 00:00:00
abstract::We aimed to investigate long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) using a meta-analysis from updated published randomized trials. Our data showed that the risk of all-cause death as well as cardi...
journal_title:American heart journal
pub_type: 信件,meta分析
doi:10.1016/j.ahj.2020.06.001
更新日期:2020-09-01 00:00:00
abstract::We studied the diagnostic value of exercise electrocardiographic (ECG) testing in 191 patients who were completely asymptomatic 6 months after a successful percutaneous transluminal coronary angioplasty procedure. With > 70%- and > 50%-diameter stenosis at follow-up as restenosis criteria, the sensitivities of exercis...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(95)90267-8
更新日期:1995-03-01 00:00:00
abstract::Nearly 800,000 of the 1 million patients hospitalized with acute heart failure (AHF) every year are initially treated by emergency physicians. Signs and symptoms are typically most severe at initial presentation, but with timely diagnostic and therapeutic management, rapid improvement can be achieved. As a direct resu...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2013.03.009
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:It is unclear whether fibrinogen predicts cardiovascular events independently of echocardiographic cardiovascular abnormalities and traditional risk factors. METHODS:We studied 2671 American Indians who participated in the second Strong Heart Study examination (1993-1995) and were observed for an average of...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.144
更新日期:2003-03-01 00:00:00
abstract::Little is known about the impact of accountable care organizations (ACO) on hospitalized heart failure (HF) patients, a high-cost and high-risk population. OBJECTIVE:We linked Medicare fee-for-service claims from 2013 to 2015 with data from American Heart Association Get With The Guidelines-HF registry to compare HF ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2020.04.028
更新日期:2020-08-01 00:00:00
abstract::Adventitial heparin delivery has been shown to inhibit thrombosis and neointimal thickening in a rat carotid injury model. To determine whether sustained, local delivery of hirulog, a potent antithrombin agent, inhibits thrombus formation and neointimal thickening after arterial stenting, silicone polymers containing ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90343-9
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Dyspnea is a complex system with multiple etiologies, including myocardial ischemia ("anginal equivalent"). Few studies have examined the utility of stress testing to detect coronary artery disease in this setting. The purpose of this study was to examine the prevalence, severity, and prognostic value of per...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.03.002
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:To evaluate the impact of adjunctive high-dose glucose-insulin-potassium (GIK) on ST-segment elevation resolution in patients with ST-segment elevation myocardial infarction (MI). METHODS:As part of a randomized controlled trial of GIK versus no GIK in patients treated with primary percutaneous coronary int...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2005.03.023
更新日期:2005-06-01 00:00:00
abstract::Because limited information is available on significant arrhythmias after myocardial infarction in pediatric patients, this study was performed to determine the incidence and impact of ventricular tachycardia or fibrillation on the postinfarction course in patients aged 1 day to 16 years. Review of 96 such children sh...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90400-x
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The Gly16 beta(2)-adrenergic receptor (beta(2)AR) polymorphism is a common variant of the beta(2)AR that displays depressed function caused by enhanced receptor downregulation in vitro compared with the Arg16 receptor. METHODS AND RESULTS:We studied 20 healthy, normotensive, nonsmoking white individuals who...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-8703(00)90099-1
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Little is known on the "very" long-term incidence of major adverse cardiac events (MACE), target-lesion revascularization (TLR), target-vessel revascularization and stent thrombosis after sirolimus-eluting stent (SES) implantation. We present the first study to provide a 10-year clinical follow-up in an unse...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.12.013
更新日期:2014-06-01 00:00:00
abstract::Thirty cases of paradoxical embolism are reviewed to consolidate clinical presentations and common predisposing factors. The presence of patent foramen ovale in the great majority of these patients in association with maneuvers that transiently elevate right atrial pressure is emphasized in relation to the pathophysio...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90692-7
更新日期:1986-07-01 00:00:00
abstract::Since many patients with chest pain cannot exercise adequately, an alternative stress would be useful to evaluate coronary reserve. We studied the physiologic responses to epinephrine to assess its potential. We report on 39 patients with chest pain. Doses from 0.03 to 0.30 micrograms/kg/min were administered intraven...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90477-5
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:With one-quarter of initial myocardial infarctions (MI) being unrecognized MI (UMI), recognition is critical to minimize further cardiovascular risk. Diabetes mellitus is an established risk factor for UMI. If impaired fasting glucose (IFG) also increased the risk for UMI, it would represent a significant pu...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2015.08.003
更新日期:2015-11-01 00:00:00
abstract::Atrial depressurization time measurement by Doppler ultrasound can be used to quantify stenotic mitral valve area. In this report, we present the results of a blinded trial comparing the standard Doppler method for "pressure half-time" (A) and another Doppler method we devised (B) for measurement of atrial depressuriz...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(87)90045-7
更新日期:1987-04-01 00:00:00
abstract::After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patient...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90088-7
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2016.12.004
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Several studies have shown that patency of the epicardial vessel does not guarantee optimal myocardial perfusion in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to identify clinical and angiographic correlates of unsuccessful...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.10.044
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Noninvasive methods are needed for the identification of women at highest risk for coronary artery disease (CAD) who might benefit most from aggressive preventive therapy. Identification of brachial artery atherosclerosis, which correlates with coronary artery atherosclerosis, may be useful to estimate or st...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1067/mhj.2002.121735
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:The long-term prognostic significance of elevated cardiac markers in an undifferentiated patient population with chest pain is unknown. METHODS:Serum troponin I (cTnI), creatine kinase-MB (CK-MB), and myoglobin were measured at presentation in 951 consecutive patients evaluated in the emergency department f...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.06.020
更新日期:2008-11-01 00:00:00