Abstract:
:After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patients without coronary artery disease (CAD) had serial thallium-201 images obtained for 2 to 5 hours after dipyridamole. Regions of interest were manually placed over six left ventricular segments in two projections for each of three imaging times. The myocardial thallium-201 clearance rate was calculated for each of the six segments and, using the clearance rate criterion found in canine studies, was considered abnormal if less than 6.5%/hr. Using this criterion alone, 22 of 26 patients (85%) without CAD had normal and 30 of 40 patients (75%) with CAD had abnormal myocardial thallium-201 clearance rates. A quantitative analysis of regional inhomogeneity in tracer distribution (normal was greater than or equal to 25% difference between segments) was negative in 24 of 26 patients (92%) without CAD and positive in 20 of 40 patients (50%) with CAD. When both clearance rate and regional inhomogeneity were considered, 21 of 26 patients (81%) without CAD had negative and 36 of 40 patients (90%) with CAD had positive results. Thus, post-dipyridamole myocardial clearance rate criteria derived from canine studies can be applied to clinical thallium imaging. Quantitative analysis of serial thallium-201 images after dipyridamole is optimized by using myocardial thallium-201 clearance rates. Such an approach is independent of regional inhomogeneities in tracer distribution.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Okada RD,Dai YH,Boucher CA,Pohost GMdoi
10.1016/0002-8703(84)90088-7subject
Has Abstractpub_date
1984-03-01 00:00:00pages
475-81issue
3eissn
0002-8703issn
1097-6744pii
0002-8703(84)90088-7journal_volume
107pub_type
杂志文章abstract:BACKGROUND:Previous studies have suggested that thrombolysis is used less often in blacks than in whites. However, whether the greater prevalence of contraindications or less specific electrocardiographic manifestations of myocardial infarction (MI) account for this difference is unclear. METHODS AND RESULTS:We studie...
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更新日期:2000-08-01 00:00:00
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更新日期:2019-03-01 00:00:00
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doi:10.1016/0002-8703(94)90023-x
更新日期:1994-07-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-03-01 00:00:00
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更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(94)90278-x
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0002-8703(76)80577-7
更新日期:1976-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2006.10.017
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-07-01 00:00:00
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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pub_type: 临床试验,杂志文章,meta分析
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00