Abstract：
:In over 30 years of surveillance of 2873 women, 574 developed initial clinical manifestations of CHD. A number of antecedent metabolic risk factors proved atherogenic, including blood lipids, glucose tolerance, uric acid, and menopause. Serum total cholesterol predicts as strongly in women as in men. The predictive power of cholesterol is strengthened when the total cholesterol is partitioned into its atherogenic LDL and protective HDL fractions. Contrary to the case in men, triglyceride may be a contributor to risk in older women. A total-to-HDL cholesterol ratio exceeding 7.5 equalizes the risk in men and women. Impaired glucose tolerance also eliminates the female CHD risk advantage over men, conferring a three-fold increased risk. Serum uric acid, although lower in women than in men, is equally predictive in the sexes. Central obesity confers an increased CHD risk in women and predisposes to diabetes, hyperuricemia, hypertension, and an unfavorable LDL/HDL cholesterol ratio. A combination of obesity, low HDL cholesterol, and impaired glucose tolerance predisposes especially. Age-adjusted risk of CHD is increased two- to threefold compared to pre menopausal women, even when induced surgically without removing the ovaries. It is not clear whether post menopausal estrogen replacement eliminates this excess risk. Fibrinogen is higher in women than in men, and is increased with hypertension, diabetes, hypercholesterolemia, high hematocrit, and cigarette smoking. At any level of multivariate risk, fibrinogen added to the CHD risk in women.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Kannel WBdoi
10.1016/0002-8703(87)90511-4subject
Has Abstractpub_date
1987-08-01 00:00:00pages
413-9issue
2eissn
0002-8703issn
1097-6744pii
0002-8703(87)90511-4journal_volume
114pub_type
杂志文章abstract：BACKGROUND:Calcified lesions carry the risk of suboptimal stent expansion. The purpose of this study was to investigate the impact of target lesion calcification on intracoronary ultrasound (ICUS) guided stent expansion after rotational atherectomy. METHODS:Stent expansion was assessed by ICUS in 39 patients with the ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(99)70463-1
更新日期：1999-01-01 00:00:00
abstract：:Therapeutics involves the careful balance between treatment disadvantages and advantages--the so-called risk-benefit ratio. Even after 20 years beta-blockers must be selected carefully to suit the patient's needs. This review examines several problems associated with beta-blockade. Generally, beta1-cardioselectivity i...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(88)90130-5
更新日期：1988-11-01 00:00:00
abstract：:Because limited information is available on significant arrhythmias after myocardial infarction in pediatric patients, this study was performed to determine the incidence and impact of ventricular tachycardia or fibrillation on the postinfarction course in patients aged 1 day to 16 years. Review of 96 such children sh...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(95)90400-x
更新日期：1995-06-01 00:00:00
abstract：:Fourteen fetuses with atrioventricular canal malformations were examined by two-dimensional echocardiography, pulsed-wave Doppler echocardiography, and color Doppler flow mapping. Eleven fetuses had complete and three fetuses had partial atrioventricular canal malformations. Nonimmune hydrops fetalis was associated wi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90156-c
更新日期：1991-05-01 00:00:00
abstract：:Inducible ventricular tachycardia frequently persists despite solitary class I antiarrhythmic drug therapy. To determine the effect of metoprolol as adjuvant therapy, 19 patients with clinical ventricular tachycardia with baseline inducible sustained monomorphic ventricular tachycardia and persistently inducible ventr...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90270-6
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Chronic periodontal infection is associated with an increased risk of coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the chronic inflammatory burden of periodontal disease m...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2005.10.002
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Perflenapent injectable emulsion is a newer echocardiographic contrast agent that provides chamber opacification and improved endocardial border delineation. In >1000 patients tested, adverse effects have been minimal. However, previous studies have included few patients with congestive heart failure (CHF) o...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1067/mhj.2000.106612
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study showed that cholesterol-lowering therapy prevented further events in patients with coronary heart disease and average cholesterol levels. The aim of this subgroup analysis was to assess the effects of pravastatin in women. METHOD...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,meta分析
doi：10.1067/mhj.2003.1
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Decreased responsiveness to oral antiplatelet drug therapy has been associated with an adverse outcome after coronary stenting (CS), but more studies are needed. The purpose of the present study was to prospectively evaluate this issue. METHODS:A total of 612 consecutive patients with stable or unstable cor...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2007.06.013
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:There are limited data regarding the clinical correlates and prognostic significance of echocardiographically defined mitral regurgitation (MR) early after acute myocardial infarction (MI). The current study addressed these issues. METHODS:Seven hundred thirty-seven patients with acute MI who underwent tran...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2005.01.020
更新日期：2005-12-01 00:00:00
abstract：:Intramuscular lidocaine administration is known to produce blood concentration levels considered to be therapeutic for prevention of premature ventricular contractions. This double blind study was designed to study the effect of intramuscular lidocaine in the prevention of PVC's in acute myocardial infarction. Forty-s...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-8703(76)80323-7
更新日期：1976-04-01 00:00:00
abstract：:One hundred four patients (101 men, three women), under 40 years of age, with myocardial infarction (MI), underwent coronary arteriography. Eighty patients had significant obstructive coronary artery disease (CAD) (group 1), 23 had normal coronary arteries (group 2), and one patient had coronary ostial stenosis as a r...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90680-0
更新日期：1986-07-01 00:00:00
abstract：AIMS:Cardiac e-consults may be an effective way to deliver value-oriented outpatient cardiology care in an accountable care organization. Initial results of cardiac e-consults have demonstrated high satisfaction among both patients and referring providers, no known adverse events, and low rates of diagnostic testing. N...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2015.11.019
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:In chronic heart failure the cause of exercise limitation is still unclear: ergoreceptors, muscle afferents sensitive to exercise metabolites, are proposed as a neural link between muscular abnormalities and the limited exercise responses in this syndrome. METHODS:In 92 stable patients with heart failure (3...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(99)70361-3
更新日期：1999-06-01 00:00:00
abstract：:To assess the effects of standard therapeutic interventions on the total ischemic burden, 86 patients with stable angina underwent 48 hours of ambulatory ST segment monitoring and treadmill exercise testing before and at a mean of 10 weeks after coronary artery bypass surgery (CABG) (group 1, N = 46) or percutaneous t...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90495-h
更新日期：1992-03-01 00:00:00
abstract：:An experimental canine model of pericardial effusion was designed to validate previous clinical nuclear magnetic resonance imaging (NMR) studies. Saline (n = 7), serum (n = 4), blood (10% hematocrit [n = 5]; 20% hematocrit [n = 5]), and lipid (n = 4) effusions were chosen to resemble: (1) transudative/exudative, (2) n...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90678-b
更新日期：1991-04-01 00:00:00
abstract：:To clarify the difference between alcoholic cardiomyopathy and dilated cardiomyopathy and to investigate the characteristics of alcoholic cardiomyopathy, right ventricular endomyocardial biopsy was performed, and the two diseases were compared clinically and histologically. Changes in the cardiothoracic ratio, cardiac...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(93)90175-9
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS:We examined the association between changes in lifestyle fact...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2010.12.015
更新日期：2011-04-01 00:00:00
abstract：:The conducting tissue of the heart was studied in 25 human cases of Chagas' myocarditis with a method which employs complete serial sections mounted on continuous transparent plastic tape. The pathological changes were correlated with electrocardiographic findings. The inflammation of the acute phase of Chagas' myocar...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90362-9
更新日期：1978-03-01 00:00:00
abstract：BACKGROUND:Even mild depressive symptoms during hospitalization are an independent risk factor for mortality after acute coronary syndromes (ACS). The mortality risk is highest for patients whose depressive symptoms persist after ACS. Low adherence to medications that reduce the risk of subsequent cardiac events may be...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2006.05.014
更新日期：2006-11-01 00:00:00
abstract：:The acute and chronic cellular electrophysiologic actions of ketanserin, a selective blocker of 5-hydroxytriptamine (5-HT2) receptor, were examined in the isolated rabbit ventricular muscle. This work was prompted by the recent observations that small numbers of patients treated with hypertension develop QTc prolongat...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(88)90012-9
更新日期：1988-06-01 00:00:00
abstract：:The main threat to patients with mild to moderate hypertension is coronary heart disease (CHD), but controlled trials of antihypertensive drug therapy have given disappointing results: overall, the reduction in CHD mortality (11%) and morbidity (10%) were small and nonsignificant. Recent trials comparing a beta blocke...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(87)90602-8
更新日期：1987-10-01 00:00:00
abstract：:The neutral alkaloid, ryanodine, has several actions on cardiac muscle. To delineate better its mode of action, we studied ryanodine's effect upon contracting cat papillary muscles under changing loading conditions and stimulation frequencies. We also studied ryanodine's physiologic and metabolic effects upon isolated...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90161-9
更新日期：1985-08-01 00:00:00
abstract：:Externally recorded STI were compared with invasively determined EF in 10 normal subjects and 86 patients with various forms of chronic heart disease. From phono-, apex-, and electrocardiograms and carotid pulse tracings, recorded without rigidly controlled conditions (postabsorptive state, fixed time of day, exclusio...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80246-9
更新日期：1977-03-01 00:00:00
abstract：:The clinical course and coronary arteriographic findings in eight patients with Prinzmetal's variant angina pectoris are reviewed and contrasted to previously reported cases. In six patients with S-T-elevation inferiorly, three had normal coronary arteriograms, one had complete right coronary artery occlusion, one ha...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90501-3
更新日期：1975-05-01 00:00:00
abstract：:The primary objective of this study was to apply a sophisticated coagulation monitoring system including estimation of the concentration of prothrombin fragment 1 + 2 (PTF 1 + 2) and the activity of prothrombin (coagulation factor II or FII) to cases of stent implantation and to compare the results with those of stand...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(95)90433-6
更新日期：1995-08-01 00:00:00
abstract：:The effects of 20 variables that might influence postmyocardial infarction prognosis were assessed retrospectively in 139 patients followed up for an average of 11 months after discharge from San Francisco General Hospital following an acute myocardial infarction. When these variables were analyzed with the use of mul...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90501-0
更新日期：1985-07-01 00:00:00
abstract：:Since many patients with chest pain cannot exercise adequately, an alternative stress would be useful to evaluate coronary reserve. We studied the physiologic responses to epinephrine to assess its potential. We report on 39 patients with chest pain. Doses from 0.03 to 0.30 micrograms/kg/min were administered intraven...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90477-5
更新日期：1983-04-01 00:00:00
abstract：:Increased intracellular calcium (calcium overload) is considered one of the factors that can initiate ventricular fibrillation. In addition, ventricular fibrillation itself can cause and possibly maintain calcium overload. The goal of this study was to determine whether the class IA antiarrhythmic agent procainamide c...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(95)90453-0
更新日期：1995-08-01 00:00:00
abstract：:The clinical spectrum and outcome of 119 patients with acute non-Q wave myocardial infarction (NQMI) were studied, in comparison with those of 354 patients with acute Q wave myocardial infarction (QMI). The patients with NQMI had a significantly higher incidence of preinfarction angina (73% vs 63%), previous myocardia...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90056-6
更新日期：1986-03-01 00:00:00
