Safety assessment of perflenapent emulsion for echocardiographic contrast enhancement in patients with congestive heart failure or chronic obstructive pulmonary disease.

abstract：BACKGROUND:The aim of this study was to compare rate of onset, magnitude, and consistency of platelet inhibition after administration of prasugrel or clopidogrel and to relate platelet inhibition to systemic exposure to each active metabolite. Thienopyridines are prodrugs, metabolized in vivo to active metabolites that...

journal_title：American heart journal

authors： Brandt JT,Payne CD,Wiviott SD,Weerakkody G,Farid NA,Small DS,Jakubowski JA,Naganuma H,Winters KJ

更新日期：2007-01-01 00:00:00

abstract：AIM:The EARISA Registry was designed to describe diagnostic and therapeutic resources used in Italian cardiology centers for patients with the epidemiologically most relevant cardiac diseases. This article focuses on patients with unstable angina; characteristics associated with invasive procedures were specifically an...

journal_title：American heart journal

authors： Maggioni AP,Schweiger C,Tavazzi L,Langiano T,Lucci D,Ramponi C,Repetto F,De Vita C

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:The randomized BASKET-PROVE study showed no significant differences between sirolimus-eluting stents (SES), everolimus-eluting stents (EES), and bare-metal stents (BMS) with respect to the primary end point, rates of death from cardiac causes, or myocardial infarction (MI) at 2 years of follow-up, in patient...

journal_title：American heart journal

authors： Vassalli G,Klersy C,De Servi S,Galatius S,Erne P,Eberli F,Rickli H,Hornig B,Bertel O,Bonetti P,Moccetti T,Kaiser C,Pfisterer M,Pedrazzini G,BASKET-PROVE Investigators.

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Aging represents the most powerful risk for the development of atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by which aging affects the arterial wall and its deterioration has remained essentially uncharacterized. FINDINGS:Chronic injuries to the arterial wall contribu...

journal_title：American heart journal

authors： Goldschmidt-Clermont PJ

更新日期：2003-10-01 00:00:00

abstract：:In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ...

journal_title：American heart journal

authors： Upadhya B,Brubaker PH,Morgan TM,Eggebeen JD,Jao GT,Stewart KP,Kitzman DW

更新日期：2018-07-01 00:00:00

abstract：:Although the cardiac manifestations of Lyme disease may be diverse, in general they are treatable with currently available therapies. A high index of suspicion is required to make a diagnosis, especially for patients who may lack a suggestive history of tick exposure or residence in an endemic region. Lyme disease-rel...

journal_title：American heart journal

authors： Cox J,Krajden M

更新日期：1991-11-01 00:00:00

abstract：:The recognition that the onset of cardiovascular events follows a circadian periodicity and is frequently triggered by physical or mental stresses has created new possibilities for disease prevention. Morning peaks in occurrence are now well-documented for acute myocardial infarction, sudden cardiac death, transient m...

journal_title：American heart journal

authors： Muller JE

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:The follow-up of patients with mitral and tricuspid regurgitation is important for their clinical treatment. We aimed to evaluate the reproducibility of the flow convergence method in mitral and tricuspid regurgitation. METHODS:The proximal flow convergence region was imaged with color Doppler ultrasound sc...

journal_title：American heart journal

authors： Grossmann G,Hoffmeister A,Imhof A,Giesler M,Hombach V,Spiess J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Inflammation is an important feature of atherosclerotic lesions, and the vulnerability of coronary lesions in acute myocardial infarction (AMI) at the time of onset may be related to blood levels of C-reactive protein (CRP) on admission, before CRP levels are affected by myocardial damage. METHODS:A total o...

journal_title：American heart journal

authors： Tomoda H,Aoki N

更新日期：2000-08-01 00:00:00

abstract：:Four hundred and ninety-two patients with coronary artery disease underwent analysis of their electrocardiograms, coronary arteriograms, and ventriculograms. Significant Q-waves were correlated with critical coronary occlusions (greater than or equal 75 per cent obstruction) and ventricular contractility. It was found...

journal_title：American heart journal

authors： Gottlieb RS,Duca PR,Kasparian H,Scariato A,Brest AN

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:The LaFarge equation is the most commonly used equation to estimate oxygen consumption (Vo(2)) in patients of all ages with congenital heart disease, although it was generated in patients older than 3 years. We sought to determine the validity of the LaFarge equation in estimating Vo(2) in children younger t...

journal_title：American heart journal

authors： Rutledge J,Bush A,Shekerdemian L,Schulze-Neick I,Penny D,Cai S,Li J

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Noninvasive methods are needed for the identification of women at highest risk for coronary artery disease (CAD) who might benefit most from aggressive preventive therapy. Identification of brachial artery atherosclerosis, which correlates with coronary artery atherosclerosis, may be useful to estimate or st...

journal_title：American heart journal

authors： Holubkov R,Karas RH,Pepine CJ,Rickens CR,Reichek N,Rogers WJ,Sharaf BL,Sopko G,Merz CN,Kelsey SF,McGorray SP,Reis SE

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) ablation is superior to pharmacologic therapy in achieving maintenance of normal sinus rhythm in selected patient populations. However, the procedure is resource intensive, and repeat ablations are sometimes required. We examined the predictors and trends of repeat ablation using a l...

journal_title：American heart journal

authors： Al-Hijji MA,Deshmukh AJ,Yao X,Mwangi R,Sangaralingham LR,Friedman PA,Asirvatham SJ,Packer DL,Shah ND,Noseworthy PA

更新日期：2016-01-01 00:00:00

abstract：:Plasma levels of endothelin-1 are elevated in patients with chronic heart failure; however, it is unknown whether changes in plasma endothelin-1 levels accurately reflect clinical response to therapy in these patients. To determine this, we measured plasma endothelin-1 in addition to functional, hemodynamic, and other...

journal_title：American heart journal

authors： Krum H,Gu A,Wilshire-Clement M,Sackner-Bernstein J,Goldsmith R,Medina N,Yushak M,Miller M,Packer M

更新日期：1996-02-01 00:00:00

abstract：:Standard evaluation of children with sinus node (SN) dysfunction cannot distinguish abnormal autonomic tone from intrinsic SN disease. This distinction has potentially important therapeutic and prognostic implications. Intrinsic heart rate (IHR)--the peak heart rate (HR) measured during pharmacologic combined autonomi...

journal_title：American heart journal

authors： Marcus B,Gillette PC,Garson A Jr

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Endothelin 1 is a potent endogenous vasoconstrictor neurohormone, and endothelin 1 plasma concentrations predict adverse outcomes in patients with acute heart failure (AHF). Tezosentan, an intravenous endothelin receptor antagonist, improved hemodynamics in patients with AHF; however, its effects on morbidit...

journal_title：American heart journal

authors： Teerlink JR,McMurray JJ,Bourge RC,Cleland JG,Cotter G,Jondeau G,Krum H,Metra M,O'Connor CM,Parker JD,Torre-Amione G,Van Veldhuisen DJ,Frey A,Rainisio M,Kobrin I,VERITAS Investigators.

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is a major public health problem in the United States. We assess the prevalence of diabetes in Dallas County, quantify the association between diabetes and subclinical cardiovascular disease, and assess the use of evidence-based cardiovascular disease risk-modifying therapies. METHODS:This...

journal_title：American heart journal

authors： Das SR,Vaeth PA,Stanek HG,de Lemos JA,Dobbins RL,McGuire DK

更新日期：2006-05-01 00:00:00

abstract：:Angiographic evidence of coronary dissection after angioplasty is found in 25% to 30% of cases. Although patients are usually asymptomatic, in a small percentage angioplasty-induced coronary dissection results in luminal impairment and ischemic complications. The present study was undertaken to identify factors respon...

journal_title：American heart journal

authors： Sharma SK,Israel DH,Kamean JL,Bodian CA,Ambrose JA

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to assess trends in evidence-based therapy use and short- and long-term mortality over time among older patients with non-ST-segment elevation myocardial infarction (NSTEMI). BACKGROUND:With the prevalence of national quality improvement efforts, the use of evidence-based ther...

journal_title：American heart journal

authors： Chin CT,Wang TY,Chen AY,Mathews R,Alexander KP,Roe MT,Peterson ED

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The study aimed to compare the short-term costs and long-term cost-effectiveness of 2 antithrombotics, fondaparinux and enoxaparin, for non-ST-elevation acute coronary syndrome in the United States. METHODS:It was based on a large randomized trial of 20,078 patients Fifth Organization to Assess Strategies i...

journal_title：American heart journal

authors： Sculpher MJ,Lozano-Ortega G,Sambrook J,Palmer S,Ormanidhi O,Bakhai A,Flather M,Steg PG,Mehta SR,Weintraub W

更新日期：2009-05-01 00:00:00

abstract：:The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...

journal_title：American heart journal

authors： Walter HJ,Hofman A

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Little data exist to assist to help those organizing and managing heart failure (HF) disease management (DM) programs. We aimed to describe the intensity of outpatient HF care (clinic visits and telephone calls) and medical and nonpharmacological interventions in the outpatient setting. METHODS:This was a p...

journal_title：American heart journal

authors： Shah MR,Whellan DJ,Peterson ED,Nohria A,Hasselblad V,Xue Z,Bowers MT,O'Connor CM,Califf RM,Stevenson LW

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement. However, although the benefits of this beta-blocker have been established in patients with chronic heart failure, the mechanisms underlying them and the changes in left ventricular systolic fun...

journal_title：American heart journal

authors： Capomolla S,Febo O,Gnemmi M,Riccardi G,Opasich C,Caporotondi A,Mortara A,Pinna GD,Cobelli F

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The Gly16 beta(2)-adrenergic receptor (beta(2)AR) polymorphism is a common variant of the beta(2)AR that displays depressed function caused by enhanced receptor downregulation in vitro compared with the Arg16 receptor. METHODS AND RESULTS:We studied 20 healthy, normotensive, nonsmoking white individuals who...

journal_title：American heart journal

authors： Hoit BD,Suresh DP,Craft L,Walsh RA,Liggett SB

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Treatment strategies, either invasive or noninvasive, for patients with unstable coronary artery disease still vary. There are no published studies comparing the strategies for health-related quality of life. METHODS:A total of 2457 patients with unstable coronary artery disease were randomized. We prospect...

journal_title：American heart journal

authors： Janzon M,Levin LA,Swahn E

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus and impaired glucose metabolism are associated with increased risk for cardiovascular disease (CVD). However, it is still not clear whether glucose levels can predict CVD risk among patients without diabetes. The primary aim of this study is to assess whether normoglycemic fasting plasma gl...

journal_title：American heart journal

authors： Shaye K,Amir T,Shlomo S,Yechezkel S

更新日期：2012-07-01 00:00:00

abstract：:Dobutamine (and dopamine) are potent positive inotropic drugs which are frequently given to treat decompensated congestive heart failure. This study reports on the use of ambulatory dobutamine (and dopamine) infusions in 21 outpatients with advanced congestive heart failure. Each patient was initially hospitalized, an...

journal_title：American heart journal

authors： Applefeld MM,Newman KA,Sutton FJ,Reed WP,Roffman DS,Talesnick BS,Grove WR

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:In patients with severe pulmonary hypertension (PH), right ventricular function is a main determinant of clinical stability and outcome. Supraventricular tachyarrhythmias (SVTs) may compromise cardiac function and threaten prognosis in patients with PH, but the incidence and clinical relevance of SVTs in PH ...

journal_title：American heart journal

authors： Tongers J,Schwerdtfeger B,Klein G,Kempf T,Schaefer A,Knapp JM,Niehaus M,Korte T,Hoeper MM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The treatment of cocaine-related acute coronary syndromes presents unique challenges. Although percutaneous coronary intervention in cocaine abusers appears to be safe in the short term, longer-term outcomes have not been reported. We postulated that cocaine use would be associated with increased risk for st...

journal_title：American heart journal

authors： McKee SA,Applegate RJ,Hoyle JR,Sacrinty MT,Kutcher MA,Sane DC

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:During daytime working hours, outcomes may be worse when percutaneous coronary intervention (PCI) is performed later in the day because of operator fatigue and differences in process of care. METHODS:Using the APPROACH database, we analyzed 2,492 consecutive nonurgent PCI procedures performed during working...

journal_title：American heart journal

authors： Cantor WJ,Strauss BH,Graham MM,Southern DA,Woo K,Tyrrell B,Knudtson M,Ghali WA

更新日期：2010-06-01 00:00:00