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Validity of the LaFarge equation for estimation of oxygen consumption in ventilated children with congenital heart disease younger than 3 years--a revisit.

Abstract：

BACKGROUND:The LaFarge equation is the most commonly used equation to estimate oxygen consumption (Vo(2)) in patients of all ages with congenital heart disease, although it was generated in patients older than 3 years. We sought to determine the validity of the LaFarge equation in estimating Vo(2) in children younger than 3 years undergoing cardiac catheterization with general anesthesia. METHODS:Vo(2) was measured directly using respiratory mass spectrometry in 75 sedated, paralyzed, and mechanically ventilated children in the pediatric cardiac catheterization laboratory. Age ranged from 0.13 to 24 years; 40 children being younger than 3 years. Estimated values for Vo(2) were calculated using the LaFarge equation for all patients. The agreement between measured and estimated Vo(2) was evaluated by the bias and limits of agreement in the 2 age groups. Regression analysis was used to analyze the influence of age on the agreement. RESULTS:A failure of agreement between measured and estimated Vo(2) was noted in both groups of children. As compared to the older group of patients, the agreement was significantly poorer in children younger than 3 years, with a significantly greater overestimation introduced by the LaFarge equation (11% +/- 21% vs 53% +/- 52%, P < .0001). CONCLUSION:The LaFarge equation introduces significant error in the estimation of Vo(2) in ventilated patients with congenital heart disease of all ages, particularly in children younger than 3 years.

journal_name

Am Heart J

journal_title

American heart journal

authors

Rutledge J,Bush A,Shekerdemian L,Schulze-Neick I,Penny D,Cai S,Li J

doi

10.1016/j.ahj.2010.04.003

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

109-14

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00328-5

journal_volume

160

pub_type

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