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Loss of bone marrow-derived vascular progenitor cells leads to inflammation and atherosclerosis.

Abstract：

BACKGROUND:Aging represents the most powerful risk for the development of atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by which aging affects the arterial wall and its deterioration has remained essentially uncharacterized. FINDINGS:Chronic injuries to the arterial wall contribute to the development of atherosclerosis. However, it is important to note that a complex repair system that involves both local and bone marrow-derived cells maintains arterial homeostasis and integrity. With this review, we explain how the age-dependent failure of the bone marrow to produce vascular progenitor cells responsible for such arterial repair--an inability that results from the impact of a lifetime of risk factors such as hyperlipidemia--drives atherosclerosis and its thromboembolic complications. As a consequence of such failure, the normal processes of arterial wall repair and rejuvenation are impaired. The disequilibrium that ensues between injury of the arterial wall and repair leads to atherosclerotic inflammation and consequent thromboembolic complications. CONCLUSION:The bone marrow and derived progenitor cells represent key regulators of atherosclerosis, and progress in the prevention and treatment of atherosclerosis and its thromboembolic complications will need to take into account this new dimension for the disease process.

journal_name

Am Heart J

journal_title

American heart journal

authors

Goldschmidt-Clermont PJ

doi

10.1016/j.ahj.2003.09.002

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

S5-12

issue

4 Suppl

eissn

0002-8703

issn

1097-6744

pii

S000287030300629X

journal_volume

146

pub_type

杂志文章,评审

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