Abstract：
:The recognition that the onset of cardiovascular events follows a circadian periodicity and is frequently triggered by physical or mental stresses has created new possibilities for disease prevention. Morning peaks in occurrence are now well-documented for acute myocardial infarction, sudden cardiac death, transient myocardial ischemia, and ischemic stroke. The morning increase in events begins after subjects assume an upright posture and start the day's activities, during a time of sympathetic nervous system activation. Additional triggers of onset include heavy physical exertion, sexual activity, and anger, the risks of which have been quantified in the Determinants of Myocardial Infarction Onset Study. A general hypothesis of the triggering of coronary thrombosis has been proposed. The process begins with the development of a vulnerable atherosclerotic plaque, which may become disrupted by internal forces or by external hemodynamic or vasoconstrictive changes. Once disrupted, the plaque becomes a thrombogenic focus. An occlusive thrombus is more likely to form if other factors come into play to increase coagulability and vasoconstriction. From a clinical standpoint these findings provide theoretical support for the use of long-acting agents to provide adequate anti-ischemic protection during the higher risk morning hours in patients already taking anti-ischemic medications. From a research standpoint this new information on triggering provides clues to a mechanism of onset that might lead to more effective preventive therapy. Because most deaths from coronary artery disease occur before any type of acute therapy can be given, further efforts to explore this new field are warranted.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Muller JEdoi
10.1016/s0002-8703(99)70390-xsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
S1-S8issue
4 Pt 2eissn
0002-8703issn
1097-6744pii
a96909journal_volume
137pub_type
杂志文章,评审abstract：:Three kinds of torso surface isopotential maps (measured, simulated, and difference maps) were delineated at every 1.5 (or 3) msec. during the QRS duration from the 85 unipolar lead ECG's led from the surface of a cylindrical torso model filled with perfusate and containing a canine heart undergoing Langendorff's perf...
journal_title：American heart journal
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：:The effect of participation in cardiac rehabilitation on medical costs was determined by measuring hospitalization charges for cardiac admissions over a 3-year period in 580 post-coronary event patients (58% after coronary bypass surgery, 42% after myocardial infarction), of whom 230 entered a cardiac rehabilitation p...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90696-s
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have changed since the benefits of spironolactone were reported, the prevalence of these complicati...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2004.10.005
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention (TAILOR-PCI) is the largest cardiovascular genotype-based randomized pragmatic trial (NCT#01742117) to evaluate the role of genotype-guided selection of oral P2Y12 inhibitor ther...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2020.10.069
更新日期：2021-02-01 00:00:00
abstract：:Technetium 99m-Q12 is a new cationic myocardial perfusion imaging agent that produces excellent images in human beings. The purpose of this study was to examine the separate effects of hypoxia and low flow on myocardial clearance kinetics. After a 1 mCi bolus injection, myocardial 99mTc-Q12 clearance was monitored for...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(96)90397-x
更新日期：1996-07-01 00:00:00
abstract：:To evaluate whether the identification of the different types of relations between premature ventricular contractions (PVCs) and the preceding sinus cycle length is capable of predicting the effect of beta-blockers on the PVCs themselves, 55 patients (43 men, 12 women, mean age 52.6 +/- 15.6 years) with different card...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-8703(96)90529-3
更新日期：1996-03-01 00:00:00
abstract：:Baroreflex modulation of forearm vascular resistance (FVR) has been reported to be abnormal in patients with congestive heart failure (CHF). However, the neurohumoral mechanisms for this impairment are not defined. We assessed the responses of arterial pressure, FVR, plasma norepinephrine, and plasma renin activity to...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(89)90075-6
更新日期：1989-07-01 00:00:00
abstract：:To evaluate the stability of precordial ST-segment mapping techniques in assessing ischemic myocardial injury, we studied 28 patients with acute anterior myocardial infarction using a 49-lead electrocardiographic system (1 mV. = 10 mm.). The sum of ST elevations in millimeters was taken as an index of ischemic injury,...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80011-2
更新日期：1977-05-01 00:00:00
abstract：BACKGROUND:The recent North American and European practice guidelines in patients with non-ST-segment elevation acute coronary syndrome (nSTE ACS) recommend glycoprotein IIb/IIIa (GpIIb-IIIa) inhibition in patients undergoing an early invasive treatment strategy. However, the guidelines are not explicit regarding the t...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2005.03.029
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional ca...
journal_title：American heart journal
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ahj.2017.12.013
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:Viable myocardium after acute myocardial infarction may be characterized by magnetic resonance imaging (MRI) either by demonstration of recovery of wall motion under dobutamine stress or by perfusion patterns after contrast medium administration. This study examines the relation between the two techniques. MAT...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70049-3
更新日期：1998-05-01 00:00:00
abstract：:Reductions in mobility and cognitive function linked to accrual of brain microvascular disease related white matter hyperintensities (WMHs) on magnetic resonance imaging can occur in older hypertensive patients in as little as 2 years. We have designed a trial evaluating 2 levels of ambulatory blood pressure (ABP) con...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2012.11.008
更新日期：2013-03-01 00:00:00
abstract：:Intramuscular lidocaine administration is known to produce blood concentration levels considered to be therapeutic for prevention of premature ventricular contractions. This double blind study was designed to study the effect of intramuscular lidocaine in the prevention of PVC's in acute myocardial infarction. Forty-s...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-8703(76)80323-7
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND:Despite the known benefits of cardiac rehabilitation in patients with coronary artery disease, referral rates to rehabilitation programs remain low. We determined the incidence and determinants of cardiac rehabilitation referral rates for patients undergoing percutaneous coronary intervention (PCI). METHODS...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2010.11.016
更新日期：2011-03-01 00:00:00
abstract：:The prevalence of heart failure (HF) is high and still on the rise. In 2004, an estimated 5.2 million adults in the United States carried the diagnosis of HF with a mortality rate of >19%. The incidence of HF is higher in individuals 65 years or older. As the US population grows older, the personal and economic costs ...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2009.04.007
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Heart failure still maintains a high mortality. Biomarkers reflecting different pathophysiological pathways are under evaluation to better stratify the mortality risk. The objective was to assess high-sensitivity cardiac troponin T (hs-cTnT) in combination with N-terminal pro-B type natriuretic peptide (NT-p...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2012.03.004
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Erythropoietin mitigates myocardial damage and improves ventricular performance after experimental ischemic injury. This study assessed safety and efficacy markers relevant to the biological activity of recombinant human erythropoietin (rHuEpo) in patients with acute myocardial infarction (MI). METHODS:We c...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2009.06.032
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Carcinoid syndrome may involve right carcinoid heart disease (CHD), secondary to the release of vasoactive substances. Left CHD is rare, as the inactivation of serotonin by the lung protects the left heart. We attempted to evaluate the prevalence of CHD and patent foramen ovale (PFO) with seria...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2006.02.019
更新日期：2006-05-01 00:00:00
abstract：:Endocarditis is a rare manifestation of disseminated Histoplasma capsulatum infection. A 22-year-old man presented with a seven month history of fever, weight loss, and progressive aortic insufficiency. The diagnosis of H. capsulatum was suggested by a diagnostic rise in complement fixation titers and positive echocar...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(80)90630-4
更新日期：1980-06-01 00:00:00
abstract：:To investigate the incidence and clinical significance of postoperative pericardial effusion (PE), the presence of PE was evaluated by echocardiography, 1 and 2 weeks postoperatively, in 50 patients after insertion of a valve prosthesis and in 100 patients after coronary bypass surgery (50 patients receiving a combina...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(88)90255-4
更新日期：1988-07-01 00:00:00
abstract：:Selective inhibition of sinus node function offers the possibility to decrease heart rate and reduce myocardial oxygen consumption in patients with impaired cardiac function, if myocardial contractility is not further attenuated. To study the influence of a specific sinus node inhibitor on myocardial function, alinidi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(05)80185-1
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Aldosterone antagonist therapy is recommended for selected patients with heart failure and reduced ejection fraction. Adherence to therapy in the transition from hospital to home is not well understood. METHODS:We identified patients with heart failure and reduced ejection fraction who were ≥65 years old, e...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2013.03.007
更新日期：2013-06-01 00:00:00
abstract：:In the United States there has been a dramatic decrease in age-adjusted coronary heart disease (CHD) mortality during the last 20 years. This article investigates the reasons for this decline and concludes that most of the decline in CHD has been the result of life-style changes, particularly reduction in serum choles...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/s0002-8703(05)80054-7
更新日期：1990-03-01 00:00:00
abstract：:Studies were conducted in 15 patients with coronary artery disease to determine if the type of pacing used to induce an extrasystole had a bearing on subsequent postextrasystolic potentiation (PESP) and if the fact that these were evaluated in jeopardized or nonjeopardized portions of the ventricle altered the ability...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(86)90149-3
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:Statins (3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors) are known to reduce mortality and cardiac events in patients with coronary artery disease who have not progressed to left ventricular systolic dysfunction (LVSD) and/or heart failure (HF). This study investigated the effect of changes in s...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2007.01.029
更新日期：2007-04-01 00:00:00
abstract：:Nearly 800,000 of the 1 million patients hospitalized with acute heart failure (AHF) every year are initially treated by emergency physicians. Signs and symptoms are typically most severe at initial presentation, but with timely diagnostic and therapeutic management, rapid improvement can be achieved. As a direct resu...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2013.03.009
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Despite known associations between obesity and cardiovascular disease, the relationship between obesity as reflected by body mass index (BMI) and angiographic coronary artery disease (CAD) is not fully understood. Moreover, this relationship has not been adequately defined in black patients, a group demons...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2013.12.009
更新日期：2014-04-01 00:00:00
abstract：:This case report presents a young adult with asymmetric septal hypertrophy (ASH) and syncope. Infranodal complete heart block was demonstrated as his cause for syncope. Therapy consisted of implantation of a A-V sequential pacemaker. Cardiac output determinations and systolic time intervals demonstrated the beneficial...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80177-4
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) is a recently recognized condition where biomarkers and prognosis are less well studied than in MI with obstructive coronary artery disease (MI-CAD). We therefore aimed to investigate the one-year prognostic value of high-sensitivity ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:The CD40 receptor and its ligand (CD40L) are known to modulate both inflammation and thrombosis-2 processes important for the development and clinical expression of atherosclerosis. Circulating soluble CD40L (sCD40L) concentration predicts cardiovascular risk in selected patient samples. The purpose of this ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2008.06.041
更新日期：2008-11-01 00:00:00
