Combined renin-angiotensin-aldosterone system inhibition in patients with chronic heart failure secondary to left ventricular systolic dysfunction.

abstract：:Mitral valve prolapse (MVP) is a common cardiac valve abnormality that affects women more frequently than men. We have previously shown that mild dehydration induces echocardiographic signs of MVP in approximately 50% of healthy asthenic women with previously normal cardiac findings. The present study was designed to ...

journal_title：American heart journal

authors： Aufderheide S,Lax D,Goldberg SJ

更新日期：1995-01-01 00:00:00

abstract：:In prior studies, we have shown that the antikaliuretic drugs, triamterene and amiloride, through a direct cardiac effect reduce the loss of cardiac potassium induced by the administration of digitalis. Since loss of myocardial potassium is thought to underlie digitalis arrhythmias, this study was performed to determi...

journal_title：American heart journal

authors： Seller RH,Greco J,Banach S,Seth R

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) remains a major public health issue. Data on long-term trends in the incidence of HF and survival after its onset are limited. METHODS:A prospective cohort study conducted between 1985 and 2004 in 21,906 participants of the Physicians' Health Study I who were alive and free of HF on Janua...

journal_title：American heart journal

authors： Djoussé L,Kochar J,Gaziano JM

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however,...

journal_title：American heart journal

authors： Allen NB,Lloyd-Jones D,Hwang SJ,Rasmussen-Torvik L,Fornage M,Morrison AC,Baldridge AS,Boerwinkle E,Levy D,Cupples LA,Fox CS,Thanassoulis G,Dufresne L,Daviglus M,Johnson AD,Reis J,Rotter J,Palmas W,Allison M,Pankow J

更新日期：2016-05-01 00:00:00

abstract：:A new translation of Roger's description of the clinical and anatomical findings in uncomplicated small VSD is presented. Reappraisal of Roger's observations in the light of our present understanding confirms that only our attitudes change; diseases remain the same. ...

journal_title：American heart journal

authors： Allwork SP

更新日期：1979-09-01 00:00:00

abstract：:Positive deviance studies combining qualitative and quantitative designs-a mixed-methods approach-can discover strategies to produce exemplary performance. We present the SAMI study, a national positive deviance study to discover hospital strategies associated with lower 30-day hospital risk-standardized mortality rat...

journal_title：American heart journal

authors： Krumholz HM,Curry LA,Bradley EH

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Acute heart failure (AHF) remains a major public health burden with a high prevalence and poor prognosis. Relaxin is a naturally occurring peptide hormone that increases cardiac output, arterial compliance, and renal blood flow during pregnancy. The RELAX-AHF-1 study will evaluate the effect of RLX030 (recom...

journal_title：American heart journal

authors： Ponikowski P,Metra M,Teerlink JR,Unemori E,Felker GM,Voors AA,Filippatos G,Greenberg B,Teichman SL,Severin T,Mueller-Velten G,Cotter G,Davison BA

更新日期：2012-02-01 00:00:00

abstract：:This study was designed to investigate the hypothesis that mitral valve prolapse (MVP) can be induced after diuresis in women without the abnormality who have characteristic body habitus. Fifteen tall, slim, healthy female volunteers with a normal cardiac findings, echocardiogram, and history were investigated after m...

journal_title：American heart journal

authors： Lax D,Eicher M,Goldberg SJ

更新日期：1992-12-01 00:00:00

abstract：:To investigate the mechanisms of restenosis and detect useful interventions to prevent it, reliable quantitative measurements must be evaluated. Coronary arteries of domestic and minipigs (n = 18) were mechanically injured by balloon overstretching and killed at different intervals (2 to 25 weeks) after quantitative a...

journal_title：American heart journal

authors： Bonan R,Paiement P,Scortichini D,Cloutier MJ,Leung TK

更新日期：1993-12-01 00:00:00

abstract：:We evaluated the long-term angiographic outcome of balloon angioplasty by comparing original and follow-up target coronary narrowing. Rather than using restenosis to determine outcome, as in most angioplasty studies, we took an unusual approach and analyzed outcome in terms that are commonly used in progression and re...

journal_title：American heart journal

authors： Rozenman Y,Gilon D,Sapoznikov D,Lotan C,Mosseri M,Hasin Y,Gotsman MS

更新日期：1997-05-01 00:00:00

abstract：:MAT is an uncommon arrhythmia most often seen in elderly patients with chronic pulmonary disease who are critically ill due to acute respiratory or cardiac decompensation. Its importance lies in the fact that it is commonly mistaken for AF, since both disorders are characterized by narrow ventricular complexes, irregu...

journal_title：American heart journal

authors： Scher DL,Arsura EL

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal function for patients prescribed non-vitamin K oral anticoagulants. METHOD...

journal_title：American heart journal

authors： Fanola CL,Mooney D,Cowan AJ,Ko D,Sisson EK,Henault LE,Tripodis Y,Hylek EM

更新日期：2017-02-01 00:00:00

abstract：:Under electrophysiologic studies, 44 asymptomatic chagasic individuals were studied. The mean age was 39.9 years, with 26 being male. The surface ECG showed normal tracings in 12 patients, left anterior fascicular block in three, incomplete right bundle branch block in two, and right bundle branch block in 27 (isolate...

journal_title：American heart journal

authors： Pimenta J,Miranda M,Pereira CB

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Physician adherence to guidelines is often poor, but the reasons have not been completely studied. We investigated whether physician adherence to guidelines for percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) varied by source, development methods, or the exten...

journal_title：American heart journal

authors： Leape LL,Weissman JS,Schneider EC,Piana RN,Gatsonis C,Epstein AM

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Coronary artery disease in women appears 10 to 15 years later than in men. To test the hypothesis that the effects of estrogen may manifest themselves as histologic differences in coronary plaques, we examined the hearts of premenopausal and postmenopausal women who died suddenly from coronary artery disease...

journal_title：American heart journal

authors： Burke AP,Farb A,Malcom G,Virmani R

更新日期：2001-02-01 00:00:00

abstract：:In a demographic study, the black Ohio residents were characterized by those born in Ohio and those born in other regions of the United States, and comparisons were made of rates for all deaths (1960-1967) for coronary heart disease (420), endocarditis and myocardial degeneration (421-422), hypertensive cardiovascular...

journal_title：American heart journal

authors： Mancuso TF,Redmond CK

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Type III hyperlipoproteinemia is characterized by the accumulation of chylomicron and very low density lipoprotein (VLDL) remnants. Individuals with this disorder have a high risk of premature atherosclerosis, and hypolipidemic drugs are useful in their management. METHODS:We compared, in a double-blind, pl...

journal_title：American heart journal

authors： Civeira F,Cenarro A,Ferrando J,Puzo J,Garcia-Otín AL,Mozas P,Pocoví M

更新日期：1999-07-01 00:00:00

abstract：:Thirty cases of paradoxical embolism are reviewed to consolidate clinical presentations and common predisposing factors. The presence of patent foramen ovale in the great majority of these patients in association with maneuvers that transiently elevate right atrial pressure is emphasized in relation to the pathophysio...

journal_title：American heart journal

authors： Loscalzo J

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Most analyses of complications after percutaneous coronary intervention have been limited to angiographic predictors of abrupt closure. We sought to determine the relation between baseline clinical and angiographic characteristics and clinical ischemic events and whether treatment with the platelet glycoprot...

journal_title：American heart journal

authors： Thel MC,Califf RM,Tcheng JE,Sigmon KN,Lincoff AM,Topol EJ,Ellis SG

更新日期：1999-02-01 00:00:00

abstract：:To evaluate the potential for hyperbaric oxygen (HBO) to produce transient improvement in function in areas of myocardium ischemic at rest (hibernating myocardium), 24 patients were studied within 1 week of acute myocardial infarction. Results were compared with single-photon emission computed tomography (SPECT) thall...

journal_title：American heart journal

authors： Swift PC,Turner JH,Oxer HF,O'Shea JP,Lane GK,Woollard KV

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:In a previous study from a single center, radionuclide measures of collateral flow with technetium 99m sestamibi have been shown to be significantly associated with angiographic residual (antegrade and collateral) flow and independent predictors of final infarct size in acute myocardial infarction. This stud...

journal_title：American heart journal

authors： Chareonthaitawee P,Christian TF,O'Connor MK,Berger PB,Higano ST,O'Keefe JH,Spain MG,Grines CL,Gibbons RJ

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The contemporary magnitude and prognostic implications of complete heart block (CHB) in patients with acute myocardial infarction (AMI) are unknown. As part of a community-based study of patients hospitalized with AMI in the Worcester, MA, metropolitan area, changes over time in the incidence rates of CHB co...

journal_title：American heart journal

authors： Nguyen HL,Lessard D,Spencer FA,Yarzebski J,Zevallos JC,Gore JM,Goldberg RJ

更新日期：2008-08-01 00:00:00

abstract：:Recent research indicates that silent myocardial ischemia may play a role in sudden cardiac death. To what extent treatment can reduce occurrence of silent ischemia remains to be assessed. Three classes of silent ischemia patients are identified: type 1--totally asymptomatic; type 2--post myocardial infarction; and ty...

journal_title：American heart journal

authors： Sheps DS,Heiss G

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetic properties and hemodynamic effect of molsidomine and its pharmacologically active metabolite SIN-1 were investigated in 13 healthy volunteers following single oral doses. Hemodynamic changes were measured by finger plethysmography (peripheral arterial resistance), impedance plethysmography (venous ...

journal_title：American heart journal

authors： Meinertz T,Brandstätter A,Trenk D,Jähnchen E,Ostrowski J,Gärtner W

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) is evaluating the potential benefit for reduction in major cardiovascular (CV) events from the addition of ezetimibe versus placebo to 40 mg/d of simvastatin therapy in patients who present with acute coronary syndromes and...

journal_title：American heart journal

authors： Blazing MA,Giugliano RP,Cannon CP,Musliner TA,Tershakovec AM,White JA,Reist C,McCagg A,Braunwald E,Califf RM

更新日期：2014-08-01 00:00:00

abstract：:To determine the factors relating to prognosis, the records of 15 neonates with persistent prolongation of the QT interval on the electrocardiogram after the fourth day of life were reviewed. Patients were admitted for symptoms (syncope, cardiac failure, or seizures), abnormal auscultation with an irregular heart rate...

journal_title：American heart journal

authors： Villain E,Levy M,Kachaner J,Garson A Jr

更新日期：1992-07-01 00:00:00

abstract：:Twenty-six patients with Ebstein's anomaly were classified into three types according to their clinical features, heart catheterization data, angiocardiographic and anatomical findings which were obtained on surgery or autopsy. The hemodynamics in each type were discussed. 1. Tricuspid Stenosis Dominant Type. Eight pa...

journal_title：American heart journal

authors： Takayasu S,Obunai Y,Konno S

更新日期：1978-02-01 00:00:00

abstract：:Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clin...

journal_title：American heart journal

authors： Roe MT,Mahaffey KW,Ezekowitz JA,Alexander JH,Goodman SG,Hernandez A,Temple T,Berdan L,Califf RM,Harrington RA,Peterson ED,Armstrong PW

更新日期：2015-06-01 00:00:00

abstract：:Atherosclerotic coronary artery disease is a serious clinical problem. Clinicians dealing with patients can make a diagnosis of coronary disease in several ways. Unfortunately all too often the diagnosis is made via sudden death or acute myocardial infarction. At other times the diagnosis is made by evaluation of pati...

journal_title：American heart journal

authors： Anderson HV,King SB 3rd

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is a...

journal_title：American heart journal

authors： Kolek MJ,Carlquist JF,Muhlestein JB,Whiting BM,Horne BD,Bair TL,Anderson JL

更新日期：2004-12-01 00:00:00