Coronary restenosis: evaluation of a restenosis injury index in a swine model.

Abstract:

:To investigate the mechanisms of restenosis and detect useful interventions to prevent it, reliable quantitative measurements must be evaluated. Coronary arteries of domestic and minipigs (n = 18) were mechanically injured by balloon overstretching and killed at different intervals (2 to 25 weeks) after quantitative angiographic analysis. Morphometric measurements evaluated intimal hyperplasia at 0.59 +/- 0.42 mm without relation to artery size or balloon/artery ratio. Intimal hyperplasia, expressed as the ratio of neointimal area to total wall area (A), is directly related to the injury, assessed by the ratio of internal elastic lamina (IEL) fracture length to IEL circumference (B), r = 0.84, p = 0.002. Restenosis injury index, defined as A/B, provides a useful tool for the quantitative assessment of future angioplasty-related restenosis interventions.

journal_name

Am Heart J

journal_title

American heart journal

authors

Bonan R,Paiement P,Scortichini D,Cloutier MJ,Leung TK

doi

10.1016/0002-8703(93)90531-d

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1334-40

issue

6

eissn

0002-8703

issn

1097-6744

pii

0002-8703(93)90531-D

journal_volume

126

pub_type

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