当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Effects of warfarin on markers of hypercoagulability in patients with heart failure.

Effects of warfarin on markers of hypercoagulability in patients with heart failure.

Abstract：

:Heart failure is associated with a hypercoagulable state. A single-center, randomized, double-blind, placebo-controlled trial was performed to test the hypothesis that warfarin will modify a hypercoagulable state in heart failure. This study included 76 patients with heart failure. At baseline, patients had evidence for a hypercoagulable state with elevated plasma levels of thrombin/antithrombin III (TAT) complexes (3.4 +/- 2.0 ng/ml), prothrombin fragment F1 + 2 (1.5 +/- 0.9 nmol/L), and D-dimers (630 +/- 401 ng/ml). Warfarin therapy (international normalized ratio [INR] 2.7 +/- 1.3) significantly decreased plasma levels of TAT complexes (p < 0.002), F1 + 2 (p < 0.001), and D-dimers (p < 0.001) when compared with baseline values at 1, 2, and 3 months of therapy. In contrast, patients receiving placebo had persistent elevation of TAT complexes (p = not significant [NS]), F1 + 2 (p = NS), and D-dimers (p = NS) during follow-up at 1, 2, and 3 months. The two treatment groups followed different trends over time for all three markers (p < 0.001). The effect of low-intensity warfarin (INR 1.3 +/- 0.08) versus moderate-intensity warfarin (INR 2.3 +/- 1.1 ) on markers of hypercoagulability was evaluated in 14 patients. When compared with baseline, low-intensity warfarin administration decreased plasma levels of TAT complexes (p = NS), F1 + 2 (p = 0.05), and D-dimers (p = 0.04). In these patients F1 + 2 was further reduced with moderate-intensity warfarin (p < 0.001). Our findings suggest that a hypercoagulable state in heart failure can be modified by warfarin therapy.

journal_name

Am Heart J

journal_title

American heart journal

authors

Jafri SM,Mammen EF,Masura J,Goldstein S

doi

10.1016/s0002-8703(97)70103-0

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

27-36

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(97)70103-0

journal_volume

134

pub_type

临床试验,杂志文章,随机对照试验

相关文献

AMERICAN HEART JOURNAL文献大全
  • Cangrelor reduces the risk of ischemic complications in patients with single-vessel and multi-vessel disease undergoing percutaneous coronary intervention: Insights from the CHAMPION PHOENIX trial.

    abstract：OBJECTIVE:To examine the safety and efficacy of cangrelor in patients with single-vessel disease (SVD) and multi-vessel disease (MVD). BACKGROUND:Cangrelor, an intravenous, rapidly acting P2Y12 inhibitor, is superior to clopidogrel in reducing ischemic events among patients receiving percutaneous coronary intervention...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2017.02.031

    authors： Abnousi F,Sundaram V,Yong CM,Prats J,Deliargyris EN,Stone GW,Hamm CW,Steg PG,Gibson CM,White HD,Price MJ,Généreux P,Desai M,Yang L,Ding VY,Harrington RA,Bhatt DL,Mahaffey KW

    更新日期：2017-06-01 00:00:00

  • Prolongation of refractoriness and activation time in normal canine ventricular myocardium following bolus administration of lidocaine.

    abstract：:This study examines the electrophysiologic effects of an intravenous bolus of lidocaine in the normal canine ventricle. In 14 open-chest dogs, left ventricular effective refractory period, ventricular repolarization time, and activation time were measured continuously during ventricular pacing (150/min) before, during...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90559-9

    authors： Martins JB,Kelly KJ

    更新日期：1985-03-01 00:00:00

  • Outcomes in patients with chronic kidney disease undergoing cardiac rehabilitation.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is associated with an adverse prognosis in patients with coronary heart disease. Cardiac rehabilitation (CR) improves morbidity and mortality among patients with coronary heart disease, but its impact on patients with concomitant CKD has not been described. METHODS:We compared b...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.01.048

    authors： Venkataraman R,Sanderson B,Bittner V

    更新日期：2005-12-01 00:00:00

  • Intermittent inotropic therapy in an outpatient setting: a cost-effective therapeutic modality in patients with refractory heart failure.

    abstract：:Patients with intractable heart failure (New York Heart Association [NYHA] class III and IV) who were receiving maximal conventional treatment were enrolled in an outpatient program that included inotropic infusions, intensive patient education, and close follow-up. The effects of this approach to therapy were evaluat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90315-4

    authors： Marius-Nunez AL,Heaney L,Fernandez RN,Clark WA,Ranganini A,Silber E,Denes P

    更新日期：1996-10-01 00:00:00

  • A single-blind study of doxazosin in the treatment of mild-to-moderate essential hypertensive patients with concomitant noninsulin-dependent diabetes mellitus.

    abstract：:Doxazosin, a selective alpha 1-inhibitor, was assessed for antihypertensive efficacy, effect on lipid parameters, and safety profile in 21 hypertensive patients with noninsulin-dependent diabetes mellitus. The study involved a 2- to 4-week baseline period, a 10-week period in which patients received doxazosin, 1 to 8 ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90229-3

    authors： Castrignano R,D'Angelo A,Pati T,Al Awady M,Tronca R,Crepaldi G

    更新日期：1988-12-01 00:00:00

  • Left ventricular outflow obstruction resulting from insertion of mitral prostheses leaving the native leaflets intact: adverse clinical outcome in seven patients.

    abstract：:Left ventricular (LV) outflow obstruction may result from retaining the anterior mitral leaflet when a mitral prosthesis is inserted in the mitral anulus. We retrospectively reviewed the echocardiograms (two-dimensional Doppler and Doppler color flow imaging, or transesophageal with color flow imaging) obtained in sev...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)91005-8

    authors： Waggoner AD,Pérez JE,Barzilai B,Rosenbloom M,Eaton MH,Cox JL

    更新日期：1991-08-01 00:00:00

  • Optimized duration of clopidogrel therapy following treatment with the Endeavor zotarolimus-eluting stent in real-world clinical practice (OPTIMIZE) trial: rationale and design of a large-scale, randomized, multicenter study.

    abstract：BACKGROUND:Current recommendations for antithrombotic therapy after drug-eluting stent (DES) implantation include prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel ≥12 months. However, the impact of such a regimen for all patients receiving any DES system remains unclear based on scientific eviden...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2012.09.009

    authors： Feres F,Costa RA,Bhatt DL,Leon MB,Botelho RV,King SB 3rd,de Paula JE,Mangione JA,Salvadori D Jr,Gusmão MO,Castello H Jr,Nicolela E Jr,Perin MA,Devito FS,Marin-Neto JA,Abizaid A

    更新日期：2012-12-01 00:00:00

  • Loss of bone marrow-derived vascular progenitor cells leads to inflammation and atherosclerosis.

    abstract：BACKGROUND:Aging represents the most powerful risk for the development of atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by which aging affects the arterial wall and its deterioration has remained essentially uncharacterized. FINDINGS:Chronic injuries to the arterial wall contribu...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2003.09.002

    authors： Goldschmidt-Clermont PJ

    更新日期：2003-10-01 00:00:00

  • Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents.

    abstract：BACKGROUND:Whether low-molecular-weight heparin (LMWH) is superior to unfractionated heparin (UFH) in acute ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) remains unclear. METHODS:A total of 3,372 STEMI patients wh...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ahj.2009.12.041

    authors： Li YJ,Rha SW,Chen KY,Poddar KL,Jin Z,Minami Y,Wang L,Dang Q,Li GP,Ramasamy S,Park JY,Choi CU,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ,Jeong MH,Ahn YK,Hong TJ,Park JS,Kim YJ,Hur SH,Seong IW,Chae JK,Cho MC,Bae

    更新日期：2010-04-01 00:00:00

  • Alcohol-induced changes in serum lipoproteins and in their metabolism.

    abstract：:The effects of alcohol intake on serum lipids and lipoproteins depend on the dose and mode of alcohol intake, individual susceptibility, genetic variables, and dietary factors. Therefore the changes of lipoprotein pattern are different among moderate and heavy drinkers. Moderate intake of alcohol increases the concent...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(87)90614-4

    authors： Taskinen MR,Nikkilä EA,Välimäki M,Sane T,Kuusi T,Kesäniemi A,Ylikahri R

    更新日期：1987-02-01 00:00:00

  • Temporal trends and hospital-level variation of inhospital cardiac arrest incidence and outcomes in the Veterans Health Administration.

    abstract：BACKGROUND:Despite significant attention to resuscitation care by hospitals, national data on trends in the incidence and survival of patients with inhospital cardiac arrest (IHCA) are limited. OBJECTIVE:To determine trends and hospital-level variation in the incidence and outcomes associated with IHCA. In exploratory...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2017.05.018

    authors： Bradley SM,Kaboli P,Kamphuis LA,Chan PS,Iwashyna TJ,Nallamothu BK

    更新日期：2017-11-01 00:00:00

  • Prospective evaluation of parenteral magnesium sulfate in the treatment of patients with reentrant AV supraventricular tachycardia.

    abstract：:This study prospectively assessed the electrophysiologic effects of parenteral magnesium sulfate administration on paroxysmal atrioventricular (AV) reentrant supraventricular tachycardia and the efficacy of magnesium to terminate these arrhythmias. Eleven normomagnesemic patients, seven with orthodromic reentrant supr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(05)80021-3

    authors： Sager PT,Widerhorn J,Petersen R,Leon C,Ryzen E,Rude R,Rahimtoola SH,Bhandari AK

    更新日期：1990-02-01 00:00:00

  • Daily variability of electrically induced reciprocating tachycardia in patients with atrioventricular accessory pathways.

    abstract：:Sequential bedside electrophysiologic testing was performed over 22 hours at intervals of 1 to 2 hours in 13 patients with left-sided Kent bundles to assess possible daily variations in the capacity to electrically induce reciprocating tachycardia. In all patients the tachycardia involved the accessory pathway in retr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90499-6

    authors： Cinca J,Moya A,Bardají A,Figueras J,Rius J

    更新日期：1987-08-01 00:00:00

  • Dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging: a new marker of triple-vessel disease.

    abstract：:To investigate the significance and mechanism of dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging, we performed both dipyridamole thallium-201 imaging and dipyridamole radionuclide angiography on 83 patients with known angiograms. The dipyridamole/delayed ratio of the left ventricular dim...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90713-r

    authors： Takeishi Y,Tono-oka I,Ikeda K,Komatani A,Tsuiki K,Yasui S

    更新日期：1991-02-01 00:00:00

  • Segmental evaluation of left ventricular wall motion after myocardial infarction: magnetic resonance imaging versus echocardiography.

    abstract：:To assess relative capabilities of magnetic resonance (MR) imaging and two-dimensional echocardiography (2DE) for evaluating regional contractile dysfunction in the left ventricle after a myocardial infarction, results from 22 concurrent MR (orthogonal-transaxial, ECG-gated, multiphasic, single-spin echo) and 2DE exam...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90533-9

    authors： White RD,Cassidy MM,Cheitlin MD,Emilson B,Ports TA,Lim AD,Botvinick EH,Schiller NB,Higgins CB

    更新日期：1988-01-01 00:00:00

  • High-risk myocardial infarction in the young: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.

    abstract：BACKGROUND:Advanced age is a well-established prognostic risk factor after acute myocardial infarction (AMI), yet approximately 10% of MIs occur in patients <45 years. We examined characteristics, cardiovascular outcomes, and the influence of risk factors on outcomes in young survivors of AMI. METHODS:Fourteen thousan...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2007.11.016

    authors： Anderson RE,Pfeffer MA,Thune JJ,McMurray JJ,Califf RM,Velazquez E,White HD,Rouleau JL,Skali H,Maggioni A,Solomon SD

    更新日期：2008-04-01 00:00:00

  • Operative and long-term survival of elderly is significantly improved by mitral valve repair.

    abstract：BACKGROUND:We review our 10-year experience of mitral valve (MV) repair in comparison with MV replacement in the elderly for floppy mitral valves/mitral valve prolapse (FMV/MVP). The use of MV repair for this entity has not been fully utilized by surgeons. METHODS:Two hundred ninety-two consecutive patients aged > or ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.07.003

    authors： Gogbashian A,Sepic J,Soltesz EG,Nascimben L,Cohn LH

    更新日期：2006-06-01 00:00:00

  • High-dose, brief intravenous streptokinase early in acute myocardial infarction.

    abstract：:An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(82)90267-8

    authors： Spann JF,Sherry S,Carabello BA,Mann RH,McCann WD,Gault JH,Gentzler RD,Rosenberg KM,Maurer AH,Denenberg BS,Warner HF,Rubin RN,Malmud LS,Comerota A

    更新日期：1982-10-01 00:00:00

  • Hemodynamic evaluation of the Ionescu-Shiley pericardial xenograft in the mitral position.

    abstract：:Hemodynamic studies were performed in 27 patients at a mean interval of 40.3 (range 24 to 59) months following mitral valve replacement with pericardial xenografts. Six patients had sequential studies, one before operation and two separate investigations at mean intervals of 11.2 and 42.8 months following valve replac...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90301-0

    authors： Tandon AP,Smith DR,Ionescu MI

    更新日期：1978-05-01 00:00:00

  • Age, knowledge, preferences, and risk tolerance for invasive cardiac care.

    abstract：BACKGROUND/OBJECTIVES:The extent to which individual knowledge, preferences, and priorities explain lower use of invasive cardiac care among older vs. younger adults presenting with acute coronary syndrome (ACS) is unknown. We directly surveyed a group of patients to ascertain their preferences and priorities for invas...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2019.09.008

    authors： Nanna MG,Peterson ED,Wu A,Harding T,Galanos AN,Wruck L,Alexander KP

    更新日期：2020-01-01 00:00:00

  • Angina symptoms in men and women with stable coronary artery disease and evidence of exercise-induced myocardial perfusion defects.

    abstract：BACKGROUND:To examine sex differences in pain and associated symptoms in patients with exercise-related ischemia, as well as the independence of these findings from other clinical factors. METHODS:Prospective study of 482 women and 425 men (mean age 58 years) undergoing exercise stress testing with myocardial perfusio...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.06.028

    authors： D'Antono B,Dupuis G,Fortin C,Arsenault A,Burelle D

    更新日期：2006-04-01 00:00:00

  • Incidence, presentation, diagnosis, and management of malfunctioning implantable cardioverter-defibrillator rate-sensing leads.

    abstract：:Recognition of tachyarrhythmia by an implantable cardioverter-defibrillator (ICD) requires an intact rate-sensing lead. We retrospectively examined 266 consecutive patients requiring an ICD to characterize the incidence, clinical presentation, diagnosis, and management of a defective rate-sensing lead. To identify cli...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90585-1

    authors： Daoud EG,Kirsh MM,Bolling SF,Strickberger SA,Morady F,Kou WH

    更新日期：1994-11-01 00:00:00

  • Reduction of neointimal hyperplasia after coronary stenting by pioglitazone in nondiabetic patients with metabolic syndrome.

    abstract：BACKGROUND:This study investigates whether pioglitazone reduces neointimal hyperplasia after coronary stenting in nondiabetic patients with metabolic syndrome (MS) using intravascular ultrasound (IVUS). Pioglitazone, a novel insulin-sensitizing thiazolidinedione, has been shown to reduce neointimal hyperplasia after co...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2007.02.022

    authors： Katayama T,Ueba H,Tsuboi K,Kubo N,Yasu T,Kuroki M,Saito M,Momomura S,Kawakami M

    更新日期：2007-05-01 00:00:00

  • Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS).

    abstract：:The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in ...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2019.12.020

    authors： Huang L,Tian M,Yu J,Li Q,Liu Y,Yin X,Wu JH,Marklund M,Wu Y,Li N,Elliott P,Yan LL,Labarthe DR,Hao Z,Shi J,Feng X,Zhang J,Zhang Y,Zhang R,Zhou B,Li Z,Sun J,Zhao Y,Yu Y,Neal B

    更新日期：2020-03-01 00:00:00

  • Effect of older age on diagnostic and prognostic performance of high-sensitivity troponin T in patients presenting to an emergency department.

    abstract：BACKGROUND:The effect of age on diagnostic and prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) has not been addressed adequately, so far. METHODS:High-sensitivity cardiac troponin T was measured serially in patients with acute symptoms presenting to our emergency department. We tested the diagn...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.08.003

    authors： Normann J,Mueller M,Biener M,Vafaie M,Katus HA,Giannitsis E

    更新日期：2012-11-01 00:00:00

  • Technetium 99m-Q12 kinetics in perfused rat myocardium: effects of hypoxia and low flow.

    abstract：:Technetium 99m-Q12 is a new cationic myocardial perfusion imaging agent that produces excellent images in human beings. The purpose of this study was to examine the separate effects of hypoxia and low flow on myocardial clearance kinetics. After a 1 mCi bolus injection, myocardial 99mTc-Q12 clearance was monitored for...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90397-x

    authors： Okada RD,Nguyen KN,Lauinger M,Allton IL,Johnson G 3rd

    更新日期：1996-07-01 00:00:00

  • Reversibility of bronchospasm in airway obstruction.

    abstract：:In a double-blind, randomized crossover study of 12 patients suffering from chronic bronchitis, the comparative influence of equipotent doses of pindolol (5 mg) and metoprolol (100 mg) on the bronchodilatory potential of inhaled fenoterol (0.4 mg), a beta 2-agonist, was investigated by means of body plethysmography. N...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(82)90138-7

    authors： von Wichert P

    更新日期：1982-08-01 00:00:00

  • Peripheral hemodynamic effects of captopril in patients with congestive heart failure.

    abstract：:In 14 patients with severe congestive heart failure, the effects of captopril on the forearm circulation were evaluated with strain gauge plethysmography. Changes in plasma renin activity, angiotensin II, norepinephrine, epinephrine, bradykinin, prostaglandin E2, and 6-keto-prostaglandin F1 alpha concentrations were a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90662-5

    authors： Nishimura H,Kubo S,Ueyama M,Kubota J,Kawamura K

    更新日期：1989-01-01 00:00:00

  • Longer-term impact of cardiology e-consults.

    abstract：AIMS:Cardiac e-consults may be an effective way to deliver value-oriented outpatient cardiology care in an accountable care organization. Initial results of cardiac e-consults have demonstrated high satisfaction among both patients and referring providers, no known adverse events, and low rates of diagnostic testing. N...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2015.11.019

    authors： Wasfy JH,Rao SK,Kalwani N,Chittle MD,Richardson CA,Gallen KM,Isselbacher EM,Kimball AB,Ferris TG

    更新日期：2016-03-01 00:00:00

  • Left atrial thrombus resolution in atrial fibrillation or flutter: Results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF).

    abstract：BACKGROUND:Data on left atrial/left atrial appendage (LA/LAA) thrombus resolution after non-vitamin K antagonist (VKA) oral anticoagulant treatment are scarce. The primary objective of X-TRA was to explore the use of rivaroxaban for the resolution of LA/LAA thrombi in patients with nonvalvular atrial fibrillation (AF) ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2016.05.007

    authors： Lip GY,Hammerstingl C,Marin F,Cappato R,Meng IL,Kirsch B,van Eickels M,Cohen A,X-TRA study and CLOT-AF registry investigators.

    更新日期：2016-08-01 00:00:00