Abstract：
BACKGROUND:Inflammation might promote the development of atherosclerosis, and high levels of C-reactive protein (CRP) and fibrinogen are associated with an increased risk of acute coronary events. OBJECTIVE:We assessed the levels of CRP and other risk factors in patients with angiographically documented coronary artery disease compared with healthy volunteers and patients undergoing coronary angiography who had normal coronary angiograms. METHODS:Ultrasensitive immunoassay was used to measure CRP levels in 142 patients with coronary disease (group 1), 37 patients with normal coronary angiograms (group 2), and 37 control healthy subjects (group 3). RESULTS:CRP levels were higher in group 1 (7.1 +/- 11.2 mg/L) compared with group 2 (4.8 +/- 4.0 mg/L) and group 3 (2.3 +/- 3.6 mg/L). In group 1, CRP levels were higher for patients with previous myocardial infarction (8.7 +/- 9.2 mg/L) or unstable angina (11.6 +/- 18.8 mg/L). Though CRP levels in patients with coronary artery disease and stable symptoms were higher compared with healthy volunteers (5.15 +/- 7.2 mg/L vs 2.3 +/- 3.6 mg/L, P <.05), they were similar to those observed in the control population of patients with normal coronary angiograms (4.8 +/- 4.0 mg/L). Furthermore, CRP levels were positively correlated to plasma fibrinogen but not to Chlamydia pneumoniae or Helicobacter pylori serology. CONCLUSION:These results suggest that CRP has a strong association with acute coronary events but do not support the hypothesis that CRP is a potent determinant of chronic stable coronary disease.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Abdelmouttaleb I,Danchin N,Ilardo C,Aimone-Gastin I,Angioï M,Lozniewski A,Loubinoux J,Le Faou A,Guéant JLdoi
10.1053/hj.1999.v137.92052subject
Has Abstractpub_date
1999-02-01 00:00:00pages
346-51issue
2eissn
0002-8703issn
1097-6744pii
S0002-8703(99)00511-6journal_volume
137pub_type
杂志文章abstract：:An expression representative of the rate of change of ventricular power during ejection was derived. The primary advantages of the expression are its theoretical value and its ability to characterize ventricular performance. The rate of change of ventricular power, measured during ejection, is virtually free of assump...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80577-7
更新日期：1976-02-01 00:00:00
abstract：:Epinephrine increases coronary blood flow but may not improve the balance between myocardial oxygen supply and demand during cardiopulmonary resuscitation (CPR). The objective of this study was to determine whether this balance can be improved by administering a relatively pure alpha-adrenergic vasoconstrictor, alone ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(94)90120-1
更新日期：1994-02-01 00:00:00
abstract：:Vasodilators facilitate ventricular emptying by affording earlier onset of left ventricular (LV) ejection and increased stroke volume with achievement of a reduced end-systolic pressure and volume. Agents with positive inotropic properties increase stroke volume by shifting the end-systolic pressure-volume curve to th...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(81)90738-9
更新日期：1981-09-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(81)80006-3
更新日期：1981-08-01 00:00:00
abstract：:Cross-sectional echocardiography identified two abnormal patterns of mitral valve closure in 14 patients with mitral regurgitation due to papillary muscle dysfunction: (1) in three patients with an akinetic inferior-posterior wall but normal cavity size, papillary muscle fibrosis was associated with late systolic mitr...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(79)90430-7
更新日期：1979-03-01 00:00:00
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journal_title：American heart journal
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更新日期：2006-01-01 00:00:00
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journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-04-01 00:00:00
abstract：:The aim of this study was to examine the effect of ventricular fibrillation and a subsequent defibrillation shock on ventricular excitability and refractoriness in human beings. We studied 16 consecutive patients with implantable cardioverter-defibrillators undergoing follow-up studies. The pre- and post-shock pacing ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(96)90086-1
更新日期：1996-06-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,评审
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更新日期：1993-09-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90825-1
更新日期：1984-05-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90056-6
更新日期：1986-03-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(79)90219-9
更新日期：1979-08-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2009.02.001
更新日期：2009-05-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2008.03.011
更新日期：2008-08-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80137-8
更新日期：1976-05-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90227-6
更新日期：1975-11-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2004.03.037
更新日期：2004-08-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(81)90383-5
更新日期：1981-01-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70153-x
更新日期：1998-12-01 00:00:00
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pub_type： 信件
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更新日期：1992-09-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2012-05-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(82)90275-7
更新日期：1982-03-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70014-6
更新日期：1998-10-01 00:00:00
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journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-8703(99)70262-0
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is associated with an adverse prognosis in patients with coronary heart disease. Cardiac rehabilitation (CR) improves morbidity and mortality among patients with coronary heart disease, but its impact on patients with concomitant CKD has not been described. METHODS:We compared b...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2005.01.048
更新日期：2005-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2007.03.019
更新日期：2007-06-01 00:00:00
abstract：:The purpose of this study were to determine the specificity of the head-up tilt test in normal subjects when a graded isoproterenol infusion is used, and to evaluate the role of dynamic ventricular volume change during head-up tilt as a mechanism of syncope. We prospectively studied 12 normal volunteers, each of whom ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(94)90016-7
更新日期：1994-07-01 00:00:00
abstract：:In this study, we reviewed M-mode and two-dimensional (2DE) echocardiographic observations in 13 patients with pulmonary atresia with ventricular septal defect and in six patients with truncus arteriosus in order to attempt to identify echocardiographic features distinguishing these two abnormalities in which no anato...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90528-8
更新日期：1983-02-01 00:00:00
abstract：:Over the past 11 years, a considerable body of evidence has accumulated implicating defects in the mitochondrial energy-generating pathway, oxidative phosphorylation, in a wide variety of degenerative diseases including myopathy and cardiomyopathy. Most classes of pathogenic mitochondrial DNA mutations affect the hear...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1067/mhj.2000.103934
更新日期：2000-02-01 00:00:00
