Protection of ischemic myocardium by whole-body hypothermia after coronary artery occlusion in dogs.

Abstract:

:Anesthetized dogs were cooled to a core body temperature of 26 degree C. or maintained at a body temperature of 37 degree C. during periods of 5 and 10 hours of LAD coronary artery occlusion. Subsequent macroscopic dehydrogenase enzyme mapping showed that ischemic injury was 25 per cent less after 5 hours of coronary occlusion and 20 per cent less after 10 hours of occlusion in hypothermic dogs than in normothermic controls. The heart rate and left ventricular minute work in hypothermic dogs decreased to roughly half the levels measured in normothermic animals, while left ventricular contractility was 10 to 40 per cent lower in hypothermic dogs than in normothermic dogs. However, cardiac index and left ventricular end-diastolic pressure were unchanged by whole-body cooling. Thus, hypothermia appeared to diminish the oxygen requirements of the ischemic myocardium without reducing the performance of the heart as a pump. Hypothermia may be useful as a therapeutic adjunct to myocardial revascularization or pharmacologic interventions.

journal_name

Am Heart J

journal_title

American heart journal

authors

Abendschein DR,Tacker WA Jr,Babbs CF

doi

10.1016/0002-8703(78)90010-8

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

772-80

issue

6

eissn

0002-8703

issn

1097-6744

pii

0002-8703(78)90010-8

journal_volume

96

pub_type

杂志文章
  • Pathobiology of atherosclerosis and plaque complications.

    abstract::To understand the process of atherosclerosis, the homeostatic and protective functions of the endothelium must be considered. The endothelium serves as the interface between blood flow and the vascular tissues. It normally regulates vascular tone and structure through the release of vasoactive substances and maintenan...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90251-8

    authors: Dzau VJ

    更新日期:1994-12-01 00:00:00

  • Design and rationale of the ANALYZE ST study: a prospective, nonrandomized, multicenter ST monitoring study to detect acute coronary syndrome events in implantable cardioverter-defibrillator patients.

    abstract:BACKGROUND:In the setting of ST-segment elevation myocardial infarction, timely restoration of normal blood flow is associated with improved myocardial salvage and survival. Despite improvements in door-to-needle and door-to-balloon times, there remains an unmet need with respect to improved symptom-to-door times. A pr...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.ahj.2014.05.010

    authors: Gibson CM,Krucoff M,Kirtane AJ,Rao SV,Mackall JA,Matthews R,Saba S,Waksman R,Holmes D

    更新日期:2014-10-01 00:00:00

  • Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: the comparison of efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial.

    abstract:AIMS:Paclitaxel-eluting stents (PESs) have been shown to inhibit neointimal hyperplasia after percutaneous coronary intervention. Coroflex Please (B Braun, Melsungen, Germany) is a newly developed PES. We compared the clinical and angiographic efficacy of Coroflex Please with Taxus Liberte (Boston Scientific, Natick, M...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2013.02.009

    authors: Seo JB,Kang SH,Hur SH,Park KW,Youn TJ,Park JS,Yang HM,Lee HY,Kang HJ,Koo BK,Bae JH,Kim SW,Moon KW,Choi JW,Lee SG,Chung WY,Kim SJ,Kim DI,Kim BO,Hyon MS,Park KS,Cha TJ,Yoo CW,Jeon HK,Kim HS

    更新日期:2013-05-01 00:00:00

  • The Coronary Artery Revascularisation in Diabetes (CARDia) trial: background, aims, and design.

    abstract:BACKGROUND:Patients with diabetes have an increased incidence and severity of ischemic heart disease, which leads to an increased requirement for coronary revascularization. Comparative information regarding mode of revascularization--coronary artery bypass graft surgery surgery (CABG) or percutaneous coronary interven...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.07.001

    authors: Kapur A,Malik IS,Bagger JP,Anderson JR,Kooner JS,Thomas M,Punjabi P,Mayet J,Millane T,Goedicke J,Jamrozik K,de Belder MA,Hall RJ,Beatt KJ

    更新日期:2005-01-01 00:00:00

  • Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol.

    abstract:BACKGROUND:In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement. However, although the benefits of this beta-blocker have been established in patients with chronic heart failure, the mechanisms underlying them and the changes in left ventricular systolic fun...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0002-8703(00)90036-x

    authors: Capomolla S,Febo O,Gnemmi M,Riccardi G,Opasich C,Caporotondi A,Mortara A,Pinna GD,Cobelli F

    更新日期:2000-04-01 00:00:00

  • Expanding the outcomes in clinical trials of heart failure: the quality of life and economic components of EPHESUS (EPlerenone's neuroHormonal Efficacy and SUrvival Study).

    abstract:BACKGROUND:Although quantification of the impact of treatment on survival remains the cornerstone of clinical research, the assessment of a broader range of disease outcomes is growing increasingly important. This manuscript provides an overview of the considerations made regarding quantification of a range of clinical...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1067/mhj.2002.120775

    authors: Spertus JA,Tooley J,Jones P,Poston C,Mahoney E,Deedwania P,Hurley S,Pitt B,Weintraub WS

    更新日期:2002-04-01 00:00:00

  • Physiologic responses to epinephrine infusion: the basis for a new stress test for coronary artery disease.

    abstract::Since many patients with chest pain cannot exercise adequately, an alternative stress would be useful to evaluate coronary reserve. We studied the physiologic responses to epinephrine to assess its potential. We report on 39 patients with chest pain. Doses from 0.03 to 0.30 micrograms/kg/min were administered intraven...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90477-5

    authors: Schechter E,Wilson MF,Kong YS

    更新日期:1983-04-01 00:00:00

  • Randomized evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with the COMBO dual therapy stent: rationale and design of the REDUCE trial.

    abstract:BACKGROUND:The optimal duration of dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients treated with drug eluting stents (DES) is still under debate. Recent meta-analyses on ≤6months versus 12months DAPT suggest that bleeding rates can be reduced, without a higher rate of thrombotic complications....

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2016.04.016

    authors: Camaro C,Damen SA,Brouwer MA,Kedhi E,Lee SW,Verdoia M,Barbieri L,Rognoni A,van T Hof AW,Ligtenberg E,de Boer MJ,Suryapranata H,De Luca G

    更新日期:2016-08-01 00:00:00

  • Effect of eplerenone versus spironolactone on cortisol and hemoglobin A₁(c) levels in patients with chronic heart failure.

    abstract:BACKGROUND:It has been reported that mineralocorticoid receptor antagonist improves the prognosis of chronic heart failure (CHF). Recently, hemoglobin A₁(c) (HbA₁(c)) levels have been reported to be an independent risk factor for mortality in CHF, suggesting the important role of insulin resistance in CHF. We compared ...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2010.04.024

    authors: Yamaji M,Tsutamoto T,Kawahara C,Nishiyama K,Yamamoto T,Fujii M,Horie M

    更新日期:2010-11-01 00:00:00

  • Unusual manifestations of severe sick sinus syndrome.

    abstract::An extremely athletic 56-year-old male physician was found to have profound sinus bradycardia. His only symptom was markedly increased alertness while actively exercising. During pacemaker insertion he had an episode of prolonged sinus arrest terminated by a precordial thump. This case suggests that exercise can alter...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90284-7

    authors: Marmor BM,Black MM

    更新日期:1980-07-01 00:00:00

  • Percutaneous transseptal balloon mitral valvuloplasty: the Chinese experience in 30 patients.

    abstract::The results of percutaneous transseptal balloon mitral valvuloplasty (PTBMV) in 30 Chinese patients with rheumatic mitral stenosis are reported. PTBMV with the Inoue balloon catheter was successfully performed in 27 patients without any significant complications. The mean left atrial pressure decreased from 20.15 +/- ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90061-0

    authors: Chen CR,Lo ZX,Huang ZD,Inoue KJ,Cheng TO

    更新日期:1988-05-01 00:00:00

  • Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:BACKGROUND:According to a recent meta-analysis, parathyroid hormone (PTH) excess is associated with increased cardiovascular disease (CVD) risk, but existing studies are limited. We examined in a prospective study the association of PTH with the incidence of CVD, taking into account vitamin D and other confounding vari...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2014.04.017

    authors: Folsom AR,Alonso A,Misialek JR,Michos ED,Selvin E,Eckfeldt JH,Coresh J,Pankow JS,Lutsey PL

    更新日期:2014-09-01 00:00:00

  • Mechanisms of arterial thrombosis: foundation for therapy.

    abstract::Intravascular thrombus often occurs when the rupture or fissure of an atherosclerotic plaque exposes procoagulant elements lying below the plaque surface. This process of plaque rupture is the result both of passive mechanical forces and an active cell-mediated mechanism. Recently a number of investigators have develo...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1053/hj.1998.v135.90300

    authors: Fuster V

    更新日期:1998-06-01 00:00:00

  • Editorial: Observations on the diagnosis of isolated rheumatic carditis.

    abstract::There are many similarities between the clinical features of viral heart disease and of rheumatic carditis, as defined in the revised Jones criteria for the diagnosis of rheumatic fever. Because of this, it is likely that viral heart disease has been, and still is, diagnosed as rheumatic. This situation can be avoided...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(76)80137-8

    authors: Ward C

    更新日期:1976-05-01 00:00:00

  • Does ST resolution achieved via different reperfusion strategies (fibrinolysis vs percutaneous coronary intervention) have different prognostic meaning in ST-elevation myocardial infarction? A systematic review.

    abstract:OBJECTIVE:We perform a systematic review to discern if ST resolution achieved via percutaneous coronary intervention (PCI) has a different meaning to that achieved via fibrinolysis. BACKGROUND:Resolution of ST-segment elevation in acute myocardial infarction has been widely used as a surrogate for treatment success. A...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2010.06.050

    authors: Wong CK,de la Barra SL,Herbison P

    更新日期:2010-11-01 00:00:00

  • Coaxial laser energy delivery using a steerable catheter in canine coronary arteries.

    abstract::Intracoronary delivery of argon laser energy was studied in eight anesthetized mongrel dogs. A No. 4.5 French single lumen catheter, with steerable guidewire and an optical fiber, was introduced through a Judkins-type femoral-coronary guiding catheter into three left anterior descending and eight left circumflex coron...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90007-x

    authors: Anderson HV,Zaatari GS,Roubin GS,Leimgruber PP,Gruentzig AR

    更新日期:1987-01-01 00:00:00

  • How should changes in life-style be measured in cardiovascular disease?

    abstract::Traditionally, assessment of therapy has been judged by the ability of treatment to alleviate symptoms with tolerable side effects or toxicity. In recent years, it has become obvious that more subtle and patient-oriented approaches are urgently needed to evaluate progression of cardiovascular disease and to monitor th...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90963-x

    authors: Storstein L

    更新日期:1987-07-01 00:00:00

  • Measuring costs and financial benefits in randomized controlled trials.

    abstract::Economic assessment can be incorporated into clinical trials to evaluate and compare the costs and benefits of different health care programs. In this article the three main types of evaluation are discussed: cost-effectiveness analysis, cost-utility analysis, and cost-benefit analysis. The measurement of direct and i...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-8703(05)80059-6

    authors: Bulpitt CJ,Fletcher AE

    更新日期:1990-03-01 00:00:00

  • The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction.

    abstract:BACKGROUND:CSL112 (apolipoprotein A-I [human]) is a plasma-derived apolipoprotein A-I developed for early reduction of cardiovascular risk following an acute myocardial infarction (AMI). The safety of CSL112 among AMI subjects with moderate, stage 3 chronic kidney disease (CKD) is unknown. METHODS:CSL112_2001, a multi...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2018.11.008

    authors: Gibson CM,Kerneis M,Yee MK,Daaboul Y,Korjian S,Mehr AP,Tricoci P,Alexander JH,Kastelein JJP,Mehran R,Bode C,Lewis BS,Mehta R,Duffy D,Feaster J,Halabi M,Angiolillo DJ,Duerschmied D,Ophuis TO,Merkely B

    更新日期:2019-02-01 00:00:00

  • Effect of delay on racial differences in thrombolysis for acute myocardial infarction.

    abstract:OBJECTIVE:To analyze the effect of delay times on racial differences in thrombolysis for acute myocardial infarction. BACKGROUND:Lower rates of thrombolytic therapy in blacks with acute myocardial infarction have recently been reported, but the reasons for this disparity are unknown. We hypothesized that lower rates o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.109644

    authors: Syed M,Khaja F,Rybicki BA,Wulbrecht N,Alam M,Sabbah HN,Goldstein S,Borzak S

    更新日期:2000-10-01 00:00:00

  • Sex differences in depression after coronary artery bypass graft surgery.

    abstract:BACKGROUND:Previous research suggests that after coronary artery bypass graft (CABG) surgery, women fare worse than men. This study investigates sex differences in depression during recovery from CABG surgery. METHODS:We followed 137 patients (72 men, 65 women) undergoing elective isolated first CABG surgery between J...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2005.05.005

    authors: Mitchell RH,Robertson E,Harvey PJ,Nolan R,Rodin G,Romans S,Abramson BL,Brister SJ,Ivanov J,Stewart DE

    更新日期:2005-11-01 00:00:00

  • Effects of subsequent pregnancy on left ventricular function in peripartum cardiomyopathy.

    abstract::Pregnancy has been discouraged in patients with peripartum cardiomyopathy (PPCM) to avoid the risk of precipitating recurrent or progressive left ventricular dysfunction. We assessed left ventricular size and contractile function using echocardiography in four PPCM patients prior to pregnancy, during the third trimest...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90025-d

    authors: Sutton MS,Cole P,Plappert M,Saltzman D,Goldhaber S

    更新日期:1991-06-01 00:00:00

  • Acute positive inotropic intervention: the phosphodiesterase inhibitors.

    abstract::Phosphodiesterase inhibitors that are selective for cAMP-specific cardiac and vascular PDE III comprise a new group of agents for the treatment of heart failure, which at present are limited to clinical shortterm intravenous use and research uses only. Although both intravenous amrinone and milrinone are FDA approved,...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90078-v

    authors: DiBianco R

    更新日期:1991-06-01 00:00:00

  • Changes in the QRS complex and ST segment in transmural and subendocardial myocardial infarctions. A clinicopathologic study.

    abstract::The QRS complex and ST segment in the ECGs of 80 patients who died of an acute myocardial infarction (MI) were studied in relation to the extent of the MI (subendocardial vs. transmural). Changes in the QRS complex developed in nine out of the 15 cases with an acute subendocardial MI. Five of these cases fulfilled the...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(79)90219-9

    authors: Raunio H,Rissanen V,Romppanen T,Jokinen Y,Rehnberg S,Helin M,Pyörälä K

    更新日期:1979-08-01 00:00:00

  • Clinical status of patients removed from a transplant waiting list rivals that of transplant recipients at significant cost savings.

    abstract::We retrospectively contrasted the medical outcome of patients removed from the heart transplant consideration list because of clinical improvement with that of transplant recipients. Of 60 patients awaiting transplantation, 18 were removed from the list (group A), and 42 required transplant or died (group B). Group A ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90462-7

    authors: Levine TB,Levine AB,Goldberg AD,Tobes M,Narins B,Lesch M

    更新日期:1996-12-01 00:00:00

  • Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from

    abstract:BACKGROUND:Although inflammation is a core element of atherogenesis and plasma levels of fibrinogen (FGB), homocysteine, and intercellular adhesion molecule-1 (ICAM-1) differ by race/ethnicity, little is known about the role of genetic polymorphisms in the FGB, methylenetetrahydrofolate reductase (MTHFR), and ICAM-1 ge...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.12.012

    authors: Albert MA,Pare G,Morris A,Rose L,Buring J,Ridker PM,Zee RY

    更新日期:2009-04-01 00:00:00

  • The effect of captopril on renal, coronary, and systemic hemodynamics in patients with severe congestive heart failure.

    abstract::The effects of captopril (CPT), an oral angiotensin-converting enzyme (ACE) inhibitor, on systemic failure (CHF). In 15 patients, CPT decreased mean arterial pressure from 75 +/- 3 to 60 +/- 3 mm Hg associated with a 16% increase in cardiac output, a 24% reduction in systemic vascular resistance, and a 36% decrease in...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90052-7

    authors: Powers ER,Bannerman KS,Stone J,Reison DS,Escala EL,Kalischer A,Weiss MB,Sciacca RR,Cannon PJ

    更新日期:1982-11-01 00:00:00

  • Myocardial infarction in young Indian patients: risk factors and coronary arteriographic profile.

    abstract::One hundred four patients (101 men, three women), under 40 years of age, with myocardial infarction (MI), underwent coronary arteriography. Eighty patients had significant obstructive coronary artery disease (CAD) (group 1), 23 had normal coronary arteries (group 2), and one patient had coronary ostial stenosis as a r...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90680-0

    authors: Kaul U,Dogra B,Manchanda SC,Wasir HS,Rajani M,Bhatia ML

    更新日期:1986-07-01 00:00:00

  • Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.

    abstract:BACKGROUND:Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS:We investigated sex-based differences in NIT results and subsequent cl...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2018.11.002

    authors: Pagidipati NJ,Coles A,Hemal K,Lee KL,Dolor RJ,Pellikka PA,Mark DB,Patel MR,Litwin SE,Daubert MA,Shah SH,Hoffmann U,Douglas PS,PROMISE Investigators.

    更新日期:2019-02-01 00:00:00

  • Trends and disparities in referral to cardiac rehabilitation after percutaneous coronary intervention.

    abstract:BACKGROUND:Despite the known benefits of cardiac rehabilitation in patients with coronary artery disease, referral rates to rehabilitation programs remain low. We determined the incidence and determinants of cardiac rehabilitation referral rates for patients undergoing percutaneous coronary intervention (PCI). METHODS...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2010.11.016

    authors: Aragam KG,Moscucci M,Smith DE,Riba AL,Zainea M,Chambers JL,Share D,Gurm HS

    更新日期:2011-03-01 00:00:00