Abstract：
BACKGROUND:Patients with diabetes have an increased incidence and severity of ischemic heart disease, which leads to an increased requirement for coronary revascularization. Comparative information regarding mode of revascularization--coronary artery bypass graft surgery surgery (CABG) or percutaneous coronary intervention (PCI)--is limited, mainly confined to a subanalysis of the Bypass Angioplasty Revascularization (BARI) trial, suggesting a mortality benefit of CABG over PCI. No prospective trial has specifically compared these modes of revascularization in patients with diabetes. OBJECTIVE:The Coronary Artery Revascularisation in Diabetes (CARDia) trial is designed to address the hypothesis that optimal PCI is not inferior to modern CABG as a revascularization strategy for diabetics with multivessel or complex single-vessel coronary disease. The primary end point is a composite of death, nonfatal myocardial infarction, and cerebrovascular accident at 1 year. METHOD:A total of 600 patients with diabetes are to be randomized to either PCI or CABG, with few protocol restrictions on operative techniques or use of new technology. This gives a power of 80% to detect non-inferiority of PCI assuming that the PCI 1-year event rate is 9%. A cardiac surgeon and a cardiologist must agree that a patient is suitable for revascularization by either technique prior to recruitment into the study. Twenty-one centers in the United Kingdom and Ireland are recruiting patients. Data on cost effectiveness, quality of life, and neurocognitive function are being collected. Long-term (3-5 year) follow-up data will also be collected.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Kapur A,Malik IS,Bagger JP,Anderson JR,Kooner JS,Thomas M,Punjabi P,Mayet J,Millane T,Goedicke J,Jamrozik K,de Belder MA,Hall RJ,Beatt KJdoi
10.1016/j.ahj.2004.07.001subject
Has Abstractpub_date
2005-01-01 00:00:00pages
13-9issue
1eissn
0002-8703issn
1097-6744pii
S0002870304004119journal_volume
149pub_type
杂志文章abstract：:To evaluate the mechanisms involved in nitrate tolerance, we randomized 23 patients with congestive heart failure resulting from coronary artery disease to an isosorbide dinitrate or a molsidomine infusion. The drugs were titrated to decrease pulmonary capillary wedge pressure by > or = 30% or > or = 10 mm Hg. Then is...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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