Pathobiology of atherosclerosis and plaque complications.

abstract：OBJECTIVES:The DANHEART trial is a multicenter, randomized (1:1), parallel-group, double-blind, placebo-controlled study in chronic heart failure patients with reduced ejection fraction (HFrEF). This investigator driven study will include 1500 HFrEF patients and test in a 2 × 2 factorial design: 1) if hydralazine-isoso...

journal_title：American heart journal

authors： Wiggers H,Køber L,Gislason G,Schou M,Poulsen MK,Vraa S,Nielsen OW,Bruun NE,Nørrelund H,Hollingdal M,Barasa A,Bøttcher M,Dodt K,Hansen VB,Nielsen G,Knudsen AS,Lomholdt J,Mikkelsen KV,Jonczy B,Brønnum-Schou J,Poenar

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES:The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate ...

journal_title：American heart journal

authors： Berwanger O,Nicolau JC,Carvalho AC,Jiang L,Goodman S,Nicholls SJ,Parkhomenko A,Averkov O,Tajer C,Malaga G,Kerr Saraiva JF,Fonseca F,Guimaraes HP,de Barros E Silva PGM,Damiani LP,Paisani DM,Lasagno CMR,Candido CT,Valei

更新日期：2018-08-01 00:00:00

abstract：:Dobutamine (and dopamine) are potent positive inotropic drugs which are frequently given to treat decompensated congestive heart failure. This study reports on the use of ambulatory dobutamine (and dopamine) infusions in 21 outpatients with advanced congestive heart failure. Each patient was initially hospitalized, an...

journal_title：American heart journal

authors： Applefeld MM,Newman KA,Sutton FJ,Reed WP,Roffman DS,Talesnick BS,Grove WR

更新日期：1987-09-01 00:00:00

abstract：:dal-PLAQUE is a placebo-controlled multicenter study designed to assess the effect of dalcetrapib on imaging measures of plaque inflammation and plaque burden. dal-PLAQUE is a multimodality imaging study in the context of the large dal-HEART Program. Decreased high-density lipoprotein cholesterol is linked to increase...

journal_title：American heart journal

authors： Fayad ZA,Mani V,Woodward M,Kallend D,Bansilal S,Pozza J,Burgess T,Fuster V,Rudd JH,Tawakol A,Farkouh ME

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:We evaluate a simple, bedside test that measures 1-minute heart rate variability in deep breathing as a predictor of death after myocardial infarction. METHODS:Bedside heart rate variability was assessed in 185 consecutive patients 5.1 +/- 2.5 days after a first myocardial infarction. Patients were instruct...

journal_title：American heart journal

authors： Katz A,Liberty IF,Porath A,Ovsyshcher I,Prystowsky EN

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that class III antiarrhythmic agents may have enhanced efficacy in the treatment of ventricular tachycardia. This study describes the first clinical assessment of the new class III agent ibutilide to suppress inducible monomorphic ventricular tachycardia (VT) in human beings. METHODS ...

journal_title：American heart journal

authors： Wood MA,Stambler BS,Ellenbogen KA,Gilligan DM,Perry KT,Wakefield LK,VanderLugt JT

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:More than three fourths of patients with heart failure (HF) are 65 years and older, and older age is associated with worse symptoms and prognoses than is younger age. Reduced exercise capacity is a chief HF complaint and indicates poorer prognosis, especially among elderly persons, but the mechanisms underly...

journal_title：American heart journal

authors： Forman DE,Clare R,Kitzman DW,Ellis SJ,Fleg JL,Chiara T,Fletcher G,Kraus WE,HF-ACTION Investigators.

更新日期：2009-10-01 00:00:00

abstract：:Four children with cor triatriatum underwent intraoperative transesophageal echocardiography. Two patients had cor triatriatum alone and two had associated complex congenital heart disease. Transesophageal echocardiography provided optimal imaging of these defects and provided unique information that facilitated surgi...

journal_title：American heart journal

authors： Shuler CO,Fyfe DA,Sade R,Crawford FA

更新日期：1995-03-01 00:00:00

abstract：:The efficacy of aspirin to prevent ischemic cardiovascular disease has received considerable attention recently. To determine the prevalence of aspirin use for cardiovascular disease prevention, the Minnesota Heart Survey examined population-based samples of Twin Cities' adults in 1981 to 82 and 1985 to 86. Over the 4...

journal_title：American heart journal

authors： Folsom AR,Iso H,Sprafka JM,Edlavitch SA,Luepker RV

更新日期：1988-09-01 00:00:00

abstract：:We studied the effect of propranolol administration on risk assessment based on submaximal exercise testing performed early after myocardial infarction. A total of 70 patients with recent infarction underwent modified Bruce treadmill testing with simultaneous measurement of expired gases in the absence of antianginal ...

journal_title：American heart journal

authors： Curtis JL,Houghton JL,Patterson JH,Koch G,Bradley DA,Adams KF Jr

更新日期：1991-06-01 00:00:00

abstract：:The prevalence of heart failure (HF) is high and still on the rise. In 2004, an estimated 5.2 million adults in the United States carried the diagnosis of HF with a mortality rate of >19%. The incidence of HF is higher in individuals 65 years or older. As the US population grows older, the personal and economic costs ...

journal_title：American heart journal

authors： Gradman AH,Papademetriou V

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders. METHODS:Participants were 955 men and women aged 60 years and older representative of the population in 2 Italian communities (107 with peripheral arterial di...

journal_title：American heart journal

authors： McDermott MM,Guralnik JM,Corsi A,Albay M,Macchi C,Bandinelli S,Ferrucci L

更新日期：2005-08-01 00:00:00

abstract：:Selective inhibition of sinus node function offers the possibility to decrease heart rate and reduce myocardial oxygen consumption in patients with impaired cardiac function, if myocardial contractility is not further attenuated. To study the influence of a specific sinus node inhibitor on myocardial function, alinidi...

journal_title：American heart journal

authors： Koenig W,Stauch M,Sund M,Wanjura D,Henze E

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:The impact of race and sex on clinical outcomes after percutaneous coronary interventions remains incompletely understood. Specific data on patient demographics, lesion characteristics, and outcomes of black versus white patients are poorly described. To further evaluate these issues, we analyzed the New App...

journal_title：American heart journal

authors： Marks DS,Mensah GA,Kennard ED,Detre K,Holmes DR Jr

更新日期：2000-07-01 00:00:00

abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) modulator, was the first oral disease-modifying therapy approved for relapsing forms of multiple sclerosis; it reduces autoreactive lymphocytes' egress from lymphoid tissues by down-regulating S1PRs. Sphingosine-1-phosphate signaling is implicated in a range of phy...

journal_title：American heart journal

authors： Camm J,Hla T,Bakshi R,Brinkmann V

更新日期：2014-11-01 00:00:00

abstract：:Bacterial shock due to Gram-negative bacilli is best managed by prompt control of the infection with appropriate antibiotics and surgical drainage or excision. Corticosteroids for purposes of controlling systemic reactions to bacteria and their toxins constitute adjunctive therapy. Volume repletion and respiratory sup...

journal_title：American heart journal

authors： Shubin H,Weil MH,Carlson RW

更新日期：1977-07-01 00:00:00

abstract：:Therapeutics involves the careful balance between treatment disadvantages and advantages--the so-called risk-benefit ratio. Even after 20 years beta-blockers must be selected carefully to suit the patient's needs. This review examines several problems associated with beta-blockade. Generally, beta1-cardioselectivity i...

journal_title：American heart journal

authors： Reid JL

更新日期：1988-11-01 00:00:00

abstract：:Doxorubicin (Adriamycin) is an effective anticancer agent but its therapeutic value is limited by its myocardial cardiotoxicity. To improve early detection of doxorubicin cardiotoxicity, studies were performed in patients with long-term doxorubicin treatment using pulsed Doppler echocardiography to assess the changes ...

journal_title：American heart journal

authors： Marchandise B,Schroeder E,Bosly A,Doyen C,Weynants P,Kremer R,Pouleur H

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:No-reflow after primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) is associated with poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor that might aggravate reperfusion injury. The aim of our study was to assess the relationship be...

journal_title：American heart journal

authors： Eitel I,Nowak M,Stehl C,Adams V,Fuernau G,Hildebrand L,Desch S,Schuler G,Thiele H

更新日期：2010-05-01 00:00:00

abstract：:Acute ventricular septal rupture in the setting of acute myocardial infarction continues to present clinicians with a difficult therapeutic dilemma. The role of surgical intervention and its timing remains unresolved. A collaborative study from three institutions was undertaken to examine various clinical outcomes in ...

journal_title：American heart journal

authors： Held AC,Cole PL,Lipton B,Gore JM,Antman EM,Hockman JS,Corrao J,Goldberg RJ,Alpert JS

更新日期：1988-11-01 00:00:00

abstract：:Minnesota codes (MC), expressing Q-QS, ST segment, and T wave abnormalities in ECGs taken during the acute event and at a 1-year follow-up were studied in 256 survivors of myocardial infarction (MI). On the 1-year ECGs large Q waves (MC 1.1) were more common in patients with a history of previous MI than in those with...

journal_title：American heart journal

authors： Rissanen V,Raunio H,Halinen MO,Rehnberg S

更新日期：1986-02-01 00:00:00

abstract：:Patients with impaired glucose tolerance (IGT) have increased risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Lifestyle modification and medication can prevent or delay progression to diabetes (PD), but whether such interventions also reduce the risk of CVD has not been rigorously...

journal_title：American heart journal

authors： Califf RM,Boolell M,Haffner SM,Bethel M,McMurray J,Duggal A,Holman RR,NAVIGATOR Study Group.

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves symptoms, reduces heart failure (HF)-related hospitalizations, and reverses left ventricular remodeling in some patients with moderate to severe HF and ventricular dyssynchrony defined by a prolonged QRS duration. The effects of CRT on HF outcomes in patients ...

journal_title：American heart journal

authors： Linde C,Gold M,Abraham WT,Daubert JC,REVERSE Study Group.

更新日期：2006-02-01 00:00:00

abstract：:A longitudinal study was performed in nine nonhydropic and nine hydropic fetuses with supraventricular tachycardia (SVT). First, because of a lack of reference methods in utero, the validity of spatial (length and area) and temporal parameters for semiquantitative grading of atrioventricular (AV) valve regurgitation b...

journal_title：American heart journal

authors： Gembruch U,Redel DA,Bald R,Hansmann M

更新日期：1993-05-01 00:00:00

abstract：:Currently, automated systems for quantitative analysis by intracoronary ultrasound (ICUS) are restricted to the detection of the lumen. The aim of this study was to determine the accuracy and reproducibility of a new semiautomated contour detection method, providing off-line identification of the intimal leading edge ...

journal_title：American heart journal

authors： von Birgelen C,Di Mario C,Li W,Schuurbiers JC,Slager CJ,de Feyter PJ,Roelandt JR,Serruys PW

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Diabetes is associated with a high rate of events after acute coronary syndrome and percutaneous coronary intervention despite aspirin treatment. Once daily aspirin might not provide 24-hour stable biological efficacy in patients with diabetes. We compared the biological efficacy of the same daily dose of as...

journal_title：American heart journal

authors： Dillinger JG,Drissa A,Sideris G,Bal dit Sollier C,Voicu S,Manzo Silberman S,Logeart D,Drouet L,Henry P

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bi...

journal_title：American heart journal

authors： Pan M,Medina A,Romero M,Ojeda S,Martin P,Suarez de Lezo J,Segura J,Mazuelos F,Novoa J,Suarez de Lezo J

更新日期：2014-09-01 00:00:00

abstract：:Incidence of myonecrosis in patients undergoing rotational atherectomy was evaluated by preprocedural statin use. The incidence of any myonecrosis (24.1% vs 52.3%, P < .001) or significant myonecrosis (7.5% vs 21.8%, P < .001) was significantly lower among patients pretreated with statins. This difference remained sig...

journal_title：American heart journal

authors： Gurm HS,Breitbart Y,Vivekanathan D,Yen MH,Fathi R,Ziada KM,Whitlow PL,Ellis SG

更新日期：2006-05-01 00:00:00

abstract：:To determine the results of coronary angioplasty for a first restenosis, the clinical, anatomic, and procedural data of 400 consecutive patients were compared with the data of 507 consecutive patients undergoing a first angioplasty. After angioplasty for restenosis, emergency redilatation had to be performed in only 0...

journal_title：American heart journal

authors： Piessens JH,Stammen F,Desmet W,De Scheerder IK,Willems JL

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown. METHODS:Coronary artery calcium screening strategies focused on MHR su...

journal_title：American heart journal

authors： Patel MJ,de Lemos JA,McGuire DK,See R,Lindsey JB,Murphy SA,Grundy SM,Khera A

更新日期：2009-06-01 00:00:00