Abstract:
:The efficacy of aspirin to prevent ischemic cardiovascular disease has received considerable attention recently. To determine the prevalence of aspirin use for cardiovascular disease prevention, the Minnesota Heart Survey examined population-based samples of Twin Cities' adults in 1981 to 82 and 1985 to 86. Over the 4-year period, reported use of aspirin for cardiovascular disease prophylaxis increased from 0.6% to 2.4% in women (p less than 0.05) and from 1.7% to 3.3% in men (p = 0.10). Prophylactic aspirin use was more common in older than in younger adults, in whites than in blacks, in those with a history of cardiovascular disease or hypercholesterolemia, and in health professionals and nonsmokers. Some individuals were apparently taking aspirin for "primary" prevention, although it has not yet been approved for that reason. Use of aspirin for cardiovascular disease prevention has been increasing and is likely to increase more rapidly over the next few years. This could favorably impact on mortality rates of cardiovascular disease, but untoward side effects of aspirin may be expected to increase as well.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Folsom AR,Iso H,Sprafka JM,Edlavitch SA,Luepker RVdoi
10.1016/0002-8703(88)90344-4subject
Has Abstractpub_date
1988-09-01 00:00:00pages
827-30issue
3eissn
0002-8703issn
1097-6744pii
0002-8703(88)90344-4journal_volume
116pub_type
杂志文章abstract::Of 26,294 consecutive patients monitored in a comprehensive drug surveillance program, 1067 (4 per cent) received methyldopa for treatment of hypertension. Adverse reactions attributed to methyldopa were reported in 149 patients (14 per cent), the most frequent being hypotension. Life-threatening adverse effects were ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(78)90192-8
更新日期:1978-11-01 00:00:00
abstract::In this study we have performed human leukocyte antigen (HLA)-A and B typing on nine patients with hypertrophic cardiomyopathy (HCM) and their relatives. Four patients had relatives who also had the disease. HLA typing of the familial form of HCM revealed a very close association of a given HLA-A,B haplotype with the ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90401-5
更新日期:1983-06-01 00:00:00
abstract::Histological study of the sinoatrial node (SAN) was performed in 111 patients in order to estabilsh correlations between the ECG findings and the anatomical lesions. This series includes both patients with sinus rhythm and patients with atrial arrhythmias. The results are as fololows: (a) the amount of nodal cells in ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(77)80070-7
更新日期:1977-06-01 00:00:00
abstract::Urodilatin [ANP-95-126] is a new natriuretic peptide of renal origin not subjected to tolerance in experimental congestive heart failure (CHF). To evaluate its therapeutic potentials in CHF, we investigated the efficacy of a prolonged infusion of urodilatin (15 ng/kg/min for 10 hours) in 12 patients with CHF (New York...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(95)90328-3
更新日期:1995-04-01 00:00:00
abstract::Atherosclerosis and its vascular sequela are responsible for considerable morbidity and mortality rates. Several risk factors have been implicated in the pathogenesis of atherosclerosis, and the search for other risk factors continues on the medical horizon. Renin-angiotensin system (RAS), a multienzyme, multilocale a...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/s0002-8703(97)70089-9
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is associated with increased risk of death, thromboembolic complications, and a lowered quality of life. Despite this burden, pharmacologic agents for prevention of AF in patients who achieved normal sinus rhythm are of limited utility, mostly because of serious and frequent side eff...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2008.10.027
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Insulin, in addition to its known metabolic effects, has sympatho-excitatory and vasodilatory actions on muscular blood vessels. The goal of this study was to evaluate insulin sensitivity in young women with vasovagal syncope and positive tilt test results (HUT+) and to compare it with that in patients with ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(02)94707-1
更新日期:2003-05-01 00:00:00
abstract::Selective inhibition of sinus node function offers the possibility to decrease heart rate and reduce myocardial oxygen consumption in patients with impaired cardiac function, if myocardial contractility is not further attenuated. To study the influence of a specific sinus node inhibitor on myocardial function, alinidi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80185-1
更新日期:1990-06-01 00:00:00
abstract::To assess the influence of viscosity and iodine concentration, three matched and standardized left coronary arteriograms were obtained in 20 patients using iopamidol (Isovue-370), ioversol (Optiray-320), and iohexol (Omnipaque-350). The order of contrast media was randomized and the administration of contrast was doub...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(92)90760-s
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Under the hypothesis that the G-308A polymorphism in the promoter region of the tumor necrosis factor alpha gene might increase tumor necrosis factor alpha expression, several investigations have been performed to examine the influence of the -308A allele on the risk of cardiovascular events. The results of ...
journal_title:American heart journal
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ahj.2007.02.031
更新日期:2007-05-01 00:00:00
abstract::Fasting mongrel dogs underwent hyperbaric oxygen treatment (HBOT), recombinant tissue plasminogen activator (rt-PA) treatment, and simultaneous HBOT and rt-PA treatment following prior experimental left anterior descending coronary artery occlusion for 2 hours. Thrombosis in and around a copper coil was recorded angio...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(90)90194-3
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:As stenting practice has evolved to include greater numbers of stents and adjunctive balloon catheters per case, concern has focused on the increasing costs of equipment for the delivery of stents. METHODS AND RESULTS:To evaluate temporal changes in costs of intracoronary stenting, we examined total costs, ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70193-0
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:P2Y12 receptor antagonist therapy is recommended in addition to ASA for up to 1 year after acute coronary syndrome to reduce ischemic events. In contrast, the benefit of long-term dual antiplatelet therapy beyond 1 year remains unclear. Ticagrelor is a potent, reversibly binding P2Y12 receptor-antagonist tha...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2013.12.020
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:A large proportion of patients with heart failure (HF) have a large and poorly contracting left ventricle. The noninvasive recognition of the ischemic etiology of such patients is difficult, and for this purpose, usually patients undergo coronary angiography. It has been shown that cardiovascular magnetic re...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.03.068
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Aggressive management to reduce pulmonary artery systolic pressure (PASP) and pulmonary capillary wedge pressure (PCWP) reduces hospitalization rates and is crucial for patients awaiting transplantation but may require periodic invasive monitoring with right heart catheterization. METHODS:The purpose of thi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(00)90008-5
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Preoperative use of angiotensin-blocking drug therapy (ABDT) with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and its link to occurrence of postoperative atrial fibrillation (POAF), a common marker of poor outcomes after cardiac surgery, remain controversial. METHODS:From 19...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.05.033
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.06.039
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Left atrial (LA) volume is a prognostic index in chronic mitral regurgitation (MR). However, little is known about LA function in this setting. We hypothesized that LA dysfunction is related to pulmonary hypertension in chronic MR. METHODS:Seventy-one patients with organic chronic MR who underwent real-time...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2009.05.030
更新日期:2009-08-01 00:00:00
abstract::Heart failure is associated with a hypercoagulable state. A single-center, randomized, double-blind, placebo-controlled trial was performed to test the hypothesis that warfarin will modify a hypercoagulable state in heart failure. This study included 76 patients with heart failure. At baseline, patients had evidence f...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-8703(97)70103-0
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The type of practitioners who use the standard exercise test is changing. Once a tool of the cardiologist, the standard exercise test is now being performed by internists and other noncardiologists. Because this change could be facilitated by computerization similar to the computerized interpretation program...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/s0002-8703(98)70233-9
更新日期:1998-09-01 00:00:00
abstract::In order to validate the measurement of pressure-volume loops and stroke work in humans, simultaneous digital subtraction ventriculography (DSA) and first-pass radionuclide angiocardiography (RNA) coupled with high-fidelity micromanometer left ventricular pressure measurements were undertaken in 34 patients, mean age ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90234-2
更新日期:1989-11-01 00:00:00
abstract::We report the angiographic studies of 53 consecutive patients with angiographic coronary artery disease (CAD) and recurrent sustained ventricular tachycardia occurring at least 6 weeks remote from an acute myocardial infarction. Triple-vessel disease was present in 25 patients (47%), double-vessel disease in 19 patien...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90392-7
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is a...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.05.049
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Protease inhibitors (PIs) may be associated with accelerated atherosclerosis in individuals infected with human immunodeficiency virus (HIV). We assessed the effects of HIV PIs on subclinical atherosclerosis. METHODS:The lipid profiles, C-reactive protein (CRP) levels, coronary artery calcification (CAC) sc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.125009
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers effectively reduce blood pressure in patients with renovascular disease (RVD); yet, randomized cardiovascular prevention trials of these drugs typically exclude individuals with this condition. PATIENTS AND METHODS:We studied the ass...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.05.013
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The diameter pulse waveforms (DPWs) are known to reflect the pressure waveforms at the target vessel. Our purpose was to clarify the usefulness of DPWs recorded noninvasively from the fetal inferior vena cava (IVC) for detecting cardiac function. METHODS:A paired ultrasonic phase-locked echo tracking system...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.06.015
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Today most patients with congenital heart disease survive childhood to be cared for by adult cardiologists. The number of physicians that should be trained to manage these lesions is unknown because we do not know the number of patients. METHODS:To answer this question, the expected numbers of infants with ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2003.05.003
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Chest pain in the absence of obstructive coronary artery disease (CAD) is common in women; it is frequently associated with debilitating symptoms and repeated evaluations and may be caused by coronary microvascular dysfunction. However, the prevalence and determinants of microvascular dysfunction in these wo...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.114198
更新日期:2001-05-01 00:00:00
abstract::A 35-year-old man suffered transmural diaphragmatic wall infarction immediately after receiving a nonpenetrating trauma to his chest. During subsequent months crippling angina pectoris developed and coronary arteriography was performed. A complete obstruction of the left circumflex coronary artery was demonstrated 2 c...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(76)80051-8
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Despite lower risks of access site-related complications with transradial approach (TRA), its clinical benefit for percutaneous coronary intervention (PCI) is uncertain. We conducted a systematic review and meta-analysis of clinical studies comparing TRA and transfemoral approach (TFA) for PCI. METHODS:Rand...
journal_title:American heart journal
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ahj.2012.01.015
更新日期:2012-04-01 00:00:00