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Efficacy of prolonged infusion of urodilatin [ANP-(95-126)] in patients with congestive heart failure.

Abstract：

:Urodilatin [ANP-95-126] is a new natriuretic peptide of renal origin not subjected to tolerance in experimental congestive heart failure (CHF). To evaluate its therapeutic potentials in CHF, we investigated the efficacy of a prolonged infusion of urodilatin (15 ng/kg/min for 10 hours) in 12 patients with CHF (New York Heart Association functional classes II and III) in a randomized, double-blind, placebo-controlled study. Urodilatin elevated plasma cyclic guanosine monophosphate (cGMP) concentrations and increased urinary cGMP excretion. Systolic blood pressure (121 +/- 9 mm Hg to 111 +/- 7 mm Hg) and central venous pressure (7.4 +/- 3.3 mm Hg to 5.2 +/- 3.4 mm Hg) decreased significantly, and diastolic blood pressure and heart rate remained unchanged. Urine flow (0.7 +/- 0.6 ml/min to 1.5 +/- .6 ml/min) and urinary sodium excretion (48 +/- 16 mumol/min to 180 +/- 97 mumol/min) were significantly increased. Plasma norepinephrine, renin, aldosterone, and vasopressin were unaltered. The substance was well tolerated. Thus prolonged infusion of urodilatin lowers preload and increases diuresis and natriuresis without neurohumoral activation or adverse side effects, demonstrating a profile of effects that may be beneficial in patients with CHF.

journal_name

Am Heart J

journal_title

American heart journal

authors

Elsner D,Muders F,Müntze A,Kromer EP,Forssmann WG,Riegger GA

doi

10.1016/0002-8703(95)90328-3

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

766-73

issue

4

eissn

0002-8703

issn

1097-6744

pii

0002-8703(95)90328-3

journal_volume

129

pub_type

临床试验,杂志文章,随机对照试验

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