Can computerization of the exercise test replace the cardiologist?

Abstract:

BACKGROUND:The type of practitioners who use the standard exercise test is changing. Once a tool of the cardiologist, the standard exercise test is now being performed by internists and other noncardiologists. Because this change could be facilitated by computerization similar to the computerized interpretation programs available for the resting electrocardiograph (ECG), we performed this analysis. A secondary aim was to demonstrate the effects of medication status and resting ECG abnormalities on test diagnostic characteristics because these factors affect utility of the exercise test by the generalist. METHODS AND RESULTS:A retrospective analysis was performed of consecutive patients referred at 2 university-affiliated Veteran's Affairs Medical Centers and a Hungarian Hospital for evaluation of chest pain and possible ischemic heart disease. There were 1384 consecutive male patients without a prior myocardial infarction with complete data who had exercise tests and coronary angiography between 1987 and 1997. Measurements included clinical, exercise test data, and visual interpretation of the ECG recordings as well as more than 100 computed measurements from the digitized ECG recordings and compilation of angiographic data from clinical reports. The computer measurements had similar diagnostic power compared with visual interpretation. Computerized measurements from maximal exercise or recovery were equivalent or superior to all other measurements. Prediction equations applied by computer were superior to single ECG measurements. Beta-blockers had no effect on test characteristics, whereas resting ST depression was associated with decreased specificity and increased sensitivity. CONCLUSIONS:Computerized exercise ST measurements are comparable to visual ST measurements by a cardiologist; computerized scores that included clinical and exercise test results exhibited the greatest diagnostic power. Applying scores with a computer allows the practicing physician to improve the diagnostic characteristics of the standard exercise test. This approach is successful even when there is resting ST depression, thus lessening the need for more expensive nuclear or imaging studies.

journal_name

Am Heart J

journal_title

American heart journal

authors

Atwood JE,Do D,Froelicher V,Chilton R,Dennis C,Froning J,Janosi A,Mortara D,Myers J

doi

10.1016/s0002-8703(98)70233-9

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

543-52

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002870398001380

journal_volume

136

pub_type

杂志文章,多中心研究
  • Dual chamber sequential pacing management of sinus node dysfunction: advantages over single-chamber pacing.

    abstract::Sixty-nine patients receiving atrioventricular sequential (DVI) pacemakers are compared to 67 patients receiving ventricular demand (VVI) pacemakers for control of the symptoms of sinus node dysfunction. The populations were similar with comparable preparing incidences of each assayed symptom and number of symptoms pe...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90162-4

    authors: Stone JM,Bhakta RD,Lutgen J

    更新日期:1982-12-01 00:00:00

  • Chlamydia pneumoniae infection and atherosclerotic coronary disease.

    abstract:BACKGROUND:Previous works have suggested an association between Chlamydia pneumoniae infection and coronary heart disease. We evaluated the prevalence of C. pneumoniae infection in patients with acute myocardial infarction (AMI) and coronary heart disease (CHD). METHODS AND RESULTS:Ninety-eight patients with AMI, 80 p...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(99)70371-6

    authors: Sessa R,Di Pietro M,Santino I,del Piano M,Varveri A,Dagianti A,Penco M

    更新日期:1999-06-01 00:00:00

  • Association of gut-related metabolites with outcome in acute heart failure.

    abstract:BACKGROUND:Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO is the final product of a complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates a panel of metabolites involved in...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2021.01.006

    authors: Israr MZ,Bernieh D,Salzano A,Cassambai S,Yazaki Y,Heaney LM,Jones DJL,Ng LL,Suzuki T

    更新日期:2021-01-14 00:00:00

  • Revival of transcatheter PFO closure: A meta-analysis of randomized controlled trials - impact of shunt size and age.

    abstract:BACKGROUND:Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have be...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2018.03.025

    authors: Reinthaler M,Ozga AK,Sinning D,Curio J,Al-Hindwan HS,Bäckemo Johansson J,Jung F,Lendlein A,Rauch G,Landmesser U

    更新日期:2018-07-01 00:00:00

  • Serial thallium-201 imaging after dipyridamole for coronary disease detection: quantitative analysis using myocardial clearance.

    abstract::After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patient...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90088-7

    authors: Okada RD,Dai YH,Boucher CA,Pohost GM

    更新日期:1984-03-01 00:00:00

  • Echocardiographic classification of complete atrioventricular canal defects.

    abstract::M-mode echocardiographic records of 26 patients with surgically proven complete atrioventricular canal defect were reviewed. Fragmentation of the interventricular septum and anterior displacement of the mitral annulus into the left ventricular outflow tract were noted in all patients. In 25 of 26 a common atrioventric...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(81)90228-3

    authors: Johnson GL,Twyman RE,Todd EP,Cottrill CM,Noonan JA

    更新日期:1981-05-01 00:00:00

  • Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging.

    abstract:BACKGROUND:No-reflow after primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) is associated with poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor that might aggravate reperfusion injury. The aim of our study was to assess the relationship be...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.02.019

    authors: Eitel I,Nowak M,Stehl C,Adams V,Fuernau G,Hildebrand L,Desch S,Schuler G,Thiele H

    更新日期:2010-05-01 00:00:00

  • Racial differences in long-term survival among patients with coronary artery disease.

    abstract:BACKGROUND:Cardiovascular disease is the leading cause of death among blacks and whites in the United States. Despite this, there are insufficient data on the long-term prognosis of black patients with coronary artery disease (CAD) as well as the major clinical related determinants of outcome. METHODS:We studied 22,61...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.06.014

    authors: Thomas KL,Honeycutt E,Shaw LK,Peterson ED

    更新日期:2010-10-01 00:00:00

  • The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS).

    abstract:BACKGROUND:Embolic events to the central nervous system are a major cause of morbidity and mortality in patients with infective endocarditis (IE). The appropriate role of valvular surgery in reducing such embolic events is unclear. The purpose of this study was to determine the relationship between the initiation of an...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.07.023

    authors: Dickerman SA,Abrutyn E,Barsic B,Bouza E,Cecchi E,Moreno A,Doco-Lecompte T,Eisen DP,Fortes CQ,Fowler VG Jr,Lerakis S,Miro JM,Pappas P,Peterson GE,Rubinstein E,Sexton DJ,Suter F,Tornos P,Verhagen DW,Cabell CH,ICE In

    更新日期:2007-12-01 00:00:00

  • Effects of subsequent pregnancy on left ventricular function in peripartum cardiomyopathy.

    abstract::Pregnancy has been discouraged in patients with peripartum cardiomyopathy (PPCM) to avoid the risk of precipitating recurrent or progressive left ventricular dysfunction. We assessed left ventricular size and contractile function using echocardiography in four PPCM patients prior to pregnancy, during the third trimest...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90025-d

    authors: Sutton MS,Cole P,Plappert M,Saltzman D,Goldhaber S

    更新日期:1991-06-01 00:00:00

  • Alterations in heart rate variability in patients undergoing dobutamine stress echocardiography, including patients with neurocardiogenic hypotension.

    abstract::Frequency-domain analysis of heart rate variability (HRV) appears to distinguish sympathetic and parasympathetic modulation of heart rate. The effects of acute reflex, as opposed to tonically augmented, cardiac vagal tone on HRV are not clearly defined. Power spectral components of HRV were measured in 36 patients und...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90143-4

    authors: Hogue CW Jr,Dávila-Román VG,Stein PK,Feinberg M,Lappas DG,Pérez JE

    更新日期:1995-12-01 00:00:00

  • Clinical and electrophysiologic effects of calcium channel blockers in patients receiving ibutilide.

    abstract:BACKGROUND:Ibutilide is indicated for the acute termination of atrial fibrillation and atrial flutter. Recent work concludes that ibutilide activates a late inward sodium current that is blocked by nifedipine. Because calcium channel blockers are commonly used in patients with atrial fibrillation, it is important to ex...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1067/mhj.2002.120156

    authors: Wood MA,Gilligan DM,Brown-Mahoney C,Nematzadeh F,Stambler BS,Ellenbogen KA

    更新日期:2002-01-01 00:00:00

  • Prognostic significance of the Karnofsky Performance Status score in patients with acute myocardial infarction: comparison with the left ventricular ejection fraction and the exercise treadmill test performance. The MILIS Study Group.

    abstract::The prognostic significance of functional status has not been previously studied in the setting of acute myocardial infarction. We assessed the Karnofsky Performance Status (KPS) score, a simple functional status scale that is commonly used to categorize physical ability, in 849 patients with acute myocardial infarcti...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/0002-8703(91)90141-4

    authors: Brezinski D,Stone PH,Muller JE,Tofler GH,Davis V,Parker C,Hartley LH,Braunwald E

    更新日期:1991-05-01 00:00:00

  • Baseline characteristics of patients in the coronary artery bypass graft (CABG) Patch Trial.

    abstract:BACKGROUND:Patients with left ventricular dysfunction who undergo coronary artery bypass graft (CABG) surgery frequently have late sudden cardiac death. The CABG Patch Trial is a prospective, randomized, multicenter clinical trial that randomized patients at high risk at the completion of CABG surgery to implantation o...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(97)80001-4

    authors: Curtis AB,Cannom DS,Bigger JT Jr,DiMarco JP,Estes NA 3rd,Steinman RC,Parides MK

    更新日期:1997-11-01 00:00:00

  • Arterial switch operation after Mustard procedures in adult patients with transposition of the great arteries: is it time to revise our strategy?

    abstract:BACKGROUND:After the Mustard or Senning procedure, adults with transposition of the great arteries may have right ventricular failure and require consideration of new therapies. A 2-stage arterial switch operation (ASO) may be performed as an alternative to heart transplantation. This procedure is relatively successful...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2003.09.015

    authors: Benzaquen BS,Webb GD,Colman JM,Therrien J

    更新日期:2004-03-01 00:00:00

  • A population-based analysis of the class effect of beta-blockers after myocardial infarction.

    abstract:BACKGROUND:Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. METHODS:We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of AMI from April 1996 to...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.11.008

    authors: Rinfret S,Abrahamowicz M,Tu J,Humphries K,Eisenberg MJ,Richard H,Austin PC,Pilote L

    更新日期:2007-02-01 00:00:00

  • Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis.

    abstract:BACKGROUND:Coronary artery disease in women appears 10 to 15 years later than in men. To test the hypothesis that the effects of estrogen may manifest themselves as histologic differences in coronary plaques, we examined the hearts of premenopausal and postmenopausal women who died suddenly from coronary artery disease...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.109946

    authors: Burke AP,Farb A,Malcom G,Virmani R

    更新日期:2001-02-01 00:00:00

  • Association of left ventricular dilatation and hypertrophy with chronotropic incompetence in the Framingham Heart Study.

    abstract:BACKGROUND:Chronotropic incompetence and left ventricular (LV) dilatation have both been shown to be markers of an adverse cardiovascular prognosis. Chronotropic incompetence has been described in patients with symptomatic LV dilatation and dysfunction, but the effect of asymptomatic LV dilatation and hypertrophy on ex...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(99)70415-1

    authors: Lauer MS,Larson MG,Evans JC,Levy D

    更新日期:1999-05-01 00:00:00

  • Changes occurring in the postinfarction ECG in relation to age, sex, and previous myocardial infarction.

    abstract::Minnesota codes (MC), expressing Q-QS, ST segment, and T wave abnormalities in ECGs taken during the acute event and at a 1-year follow-up were studied in 256 survivors of myocardial infarction (MI). On the 1-year ECGs large Q waves (MC 1.1) were more common in patients with a history of previous MI than in those with...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90141-9

    authors: Rissanen V,Raunio H,Halinen MO,Rehnberg S

    更新日期:1986-02-01 00:00:00

  • The acute effects of flecainide in the swine heart failing from incessant supraventricular tachycardia.

    abstract::The acute hemodynamic and electrophysiologic effects of flecainide in tachycardia-induced ventricular dysfunction were investigated using an animal model. Seven swine were initially (CON) evaluated by echocardiography and then by right heart catheterization and provocative electrical ventricular stimulation both befor...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90018-d

    authors: Trippel DL,Harold ME,Spinale FG,Buckles DS,Gillette PC

    更新日期:1991-06-01 00:00:00

  • The association between socioeconomic status of high-risk patients with coronary heart disease and the treatment rates of evidence-based medicine for coronary heart disease secondary prevention in China: Results from the Bridging the Gap on CHD Secondary

    abstract:BACKGROUND:In China, low socioeconomic status (SES) may be a barrier for patients with coronary heart disease (CHD) to receive adequate treatment because of their inadequate access to health resources. This study aims to evaluate whether and to what extent SES is associated with the treatment of CHD patients. METHODS:...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.12.009

    authors: Niu S,Zhao D,Zhu J,Liu J,Liu Q,Liu J,Wang W,Smith SC Jr,BRIG project.

    更新日期:2009-04-01 00:00:00

  • Augmentation of vessel squeezing at coronary-myocardial bridge by nitroglycerin: study by quantitative coronary angiography and intravascular ultrasound.

    abstract:BACKGROUND:Nitroglycerin is known to augment vessel wall squeezing at the site with coronary-myocardial bridging (CMB). This study was designed to define the mechanism of nitroglycerin-induced augmentation of CMB in clinical settings. METHODS:We analyzed nitroglycerin reactivity at the site with CMB in 39 patients. Ma...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(99)70123-7

    authors: Hongo Y,Tada H,Ito K,Yasumura Y,Miyatake K,Yamagishi M

    更新日期:1999-08-01 00:00:00

  • National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension.

    abstract:BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is associated with an increased risk of adverse cardiovascular outcomes. We studied the frequency and intensity of care for aTRH among participants aged 65 years and older in the US-based REGARDS study linked with Medicare claims. METHODS:Blood pressure (BP) ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2017.01.008

    authors: Vemulapalli S,Deng L,Patel MR,Kilgore ML,Jones WS,Curtis LH,Irvin MR,Svetkey LP,Shimbo D,Calhoun DA,Muntner P

    更新日期:2017-04-01 00:00:00

  • An open, noncomparative study of doxazosin in essential hypertension: experience in general practice in The Netherlands.

    abstract::The antihypertensive efficacy, safety, and lipid effects of doxazosin, a selective alpha 1-inhibitor, were assessed in a general practice setting. Three hundred twenty-six patients were entered into the study, which involved three phases: (1) a 2-week baseline period, (2) an 8-week period in which patients received 1 ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(91)90857-e

    authors: Naber FB

    更新日期:1991-01-01 00:00:00

  • Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial.

    abstract:BACKGROUND:Clinical outcomes and the effects of oral anticoagulants among patients with acute coronary syndrome (ACS) and either a history of or acute heart failure (HF) are largely unknown. We aimed to assess the relationship between prior HF or acute HF complicating an index ACS event and subsequent clinical outcomes...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2014.12.022

    authors: Cornel JH,Lopes RD,James S,Stevens SR,Neely ML,Liaw D,Miller J,Mohan P,Amerena J,Raev D,Huo Y,Urina-Triana M,Gallegos Cazorla A,Vinereanu D,Fridrich V,Harrington RA,Wallentin L,Alexander JH,APPRAISE-2 Study Group.

    更新日期:2015-04-01 00:00:00

  • A comparison of standard and high-dose regimens for the initiation of amiodarone therapy.

    abstract::The effects of two regimens for the initiation of amiodarone therapy were compared in 92 patients with inducible sustained ventricular tachycardia (VT) at baseline electrophysiologic testing. Two groups of 46 patients each received a total of 16.8 gm of oral amiodarone before follow-up electrophysiologic testing. Grou...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(92)90599-q

    authors: Summitt J,Morady F,Kadish A

    更新日期:1992-08-01 00:00:00

  • Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.

    abstract::Serum digoxin and/quinidine concentration were measured before and following the institution of quinidine therapy in 11 patients who were receiving maintenance oral digoxin therapy and who required quinidine therapy for suppression of extrasystoles. Steady-state serum digoxin concentrations after quinidine administra...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90643-3

    authors: Friedman HS,Chen TS

    更新日期:1982-07-01 00:00:00

  • Precordial ST-segment mapping 3. Stability of maps in the early phase of acute myocardial infarction.

    abstract::To evaluate the stability of precordial ST-segment mapping techniques in assessing ischemic myocardial injury, we studied 28 patients with acute anterior myocardial infarction using a 49-lead electrocardiographic system (1 mV. = 10 mm.). The sum of ST elevations in millimeters was taken as an index of ischemic injury,...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(77)80011-2

    authors: Madias JE,Hood WB Jr

    更新日期:1977-05-01 00:00:00

  • Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA).

    abstract:BACKGROUND:The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior an...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2017.02.020

    authors: Bansilal S,Vedanthan R,Kovacic JC,Soto AV,Latina J,Björkegren JLM,Jaslow R,Santana M,Sartori S,Giannarelli C,Mani V,Hajjar R,Schadt E,Kasarskis A,Fayad ZA,Fuster V

    更新日期:2017-05-01 00:00:00

  • Atrial coronary hyperemia and ischemia in response to variations in atrial pressure in dogs.

    abstract::We altered the mechanical activity of the atrial myocardium in open-chest dogs and measured changes in coronary blood flow distribution, using the radioactive microsphere technique. When left and right atrial pressures were decreased to 2 mm Hg by hypovolemia, atrial coronary blood flow fell to values nearly 50% below...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90701-9

    authors: Neill WA,Sewell DH,Gosalia KP,Kingsley EM,Oxendine JM

    更新日期:1983-09-01 00:00:00