A population-based analysis of the class effect of beta-blockers after myocardial infarction.

Abstract:

BACKGROUND:Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. METHODS:We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of AMI from April 1996 to March 2000. Administrative data from Quebec, Ontario, and British Columbia were merged. We compared patients prescribed with metoprolol, acebutolol, or atenolol within 90 days after discharge. RESULTS:Among 31576 patients, 67% were prescribed with metoprolol, 24% with atenolol, and 9% with acebutolol. Clinical characteristics and proportion of days covered with a beta-blocker prescription were similar across groups. Although controlling for time-dependent covariates representing current use and dosage, as well as for age, sex, congestive heart failure, and several other comorbidities, patients who filled a prescription for acebutolol (hazard ratio 0.71, 95% CI 0.62-0.81) or atenolol (hazard ratio 0.79, 95% CI 0.73-0.87) had significantly lower mortality in comparison with metoprolol. CONCLUSIONS:The higher mortality observed in patients receiving metoprolol compared with those receiving atenolol or acebutolol challenges the concept of a class effect of beta-blockers for secondary prevention of AMI.

journal_name

Am Heart J

journal_title

American heart journal

authors

Rinfret S,Abrahamowicz M,Tu J,Humphries K,Eisenberg MJ,Richard H,Austin PC,Pilote L

doi

10.1016/j.ahj.2006.11.008

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

224-30

issue

2

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(06)00987-2

journal_volume

153

pub_type

杂志文章
  • Impedance measurement of absolute blood flow using an angioplasty catheter: a validation study.

    abstract::An angioplasty catheter was developed to allow measurement of absolute coronary blood flow during interventional procedures. This method uses electrical impedance changes induced by a 0.5 ml bolus of 5% dextrose solution and indicator-dilution principles. The indicator is injected through a port located just proximal ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90184-j

    authors: Martin LW,Johnson RA,Scott H,Robinson S,Beauman G,Englehardt M,Vogel RA

    更新日期:1991-03-01 00:00:00

  • Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging.

    abstract::Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 micrograms/kg/min) was performed in 11 subjects. Subjec...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(07)80015-9

    authors: Villegas BJ,Hendel RC,Dahlberg ST,McSherry BA,Leppo JA

    更新日期:1993-07-01 00:00:00

  • Left atrial thrombus resolution in atrial fibrillation or flutter: Results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF).

    abstract:BACKGROUND:Data on left atrial/left atrial appendage (LA/LAA) thrombus resolution after non-vitamin K antagonist (VKA) oral anticoagulant treatment are scarce. The primary objective of X-TRA was to explore the use of rivaroxaban for the resolution of LA/LAA thrombi in patients with nonvalvular atrial fibrillation (AF) ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2016.05.007

    authors: Lip GY,Hammerstingl C,Marin F,Cappato R,Meng IL,Kirsch B,van Eickels M,Cohen A,X-TRA study and CLOT-AF registry investigators.

    更新日期:2016-08-01 00:00:00

  • Female sex is associated with a lower risk of stroke in patients with heart failure.

    abstract:BACKGROUND:Stroke in patients with heart failure is associated with poor outcomes. Risk stratification schemes may improve clinical decision making in this patient population. This study investigated whether female sex is a risk factor for stroke in patients with heart failure in sinus rhythm. METHODS:This is a popula...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2014.12.004

    authors: Melgaard L,Gorst-Rasmussen A,Lip GY,Rasmussen LH,Larsen TB

    更新日期:2015-03-01 00:00:00

  • Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation.

    abstract::The purpose of this study was to determine whether myocardium salvaged by reperfusion following coronary occlusion could respond to inotropic stimulation by dopamine. Mongrel dogs underwent a 2-hour occlusion of the proximal left anterior descending coronary artery, followed by reperfusion for 5 or 28 hours. Dopamine ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90126-1

    authors: Ellis SG,Wynne J,Braunwald E,Henschke CI,Sandor T,Kloner RA

    更新日期:1984-01-01 00:00:00

  • Pulsed wave tissue Doppler-derived myocardial performance index for the assessment of left ventricular thrombus formation risk after acute myocardial infarction.

    abstract:BACKGROUND:Assessment of left ventricular (LV) thrombosis risk after acute myocardial infarction (AMI) is important because of potential embolic sequelae that are reduced by oral anticoagulant agents. The goal of this study was to investigate whether early assessment of LV systolic and diastolic performance with pulsed...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ahj.2004.05.025

    authors: Yilmaz R,Celik S,Baykan M,Orem C,Kasap H,Durmus I,Erdol C

    更新日期:2004-12-01 00:00:00

  • Regional metabolism during coronary occlusion, reperfusion, and reocclusion using phosphorus31 nuclear magnetic resonance spectroscopy in the intact rabbit.

    abstract::Few studies have examined metabolic consequences of coronary occlusion and reperfusion using phosphorus31 nuclear magnetic resonance (31P-NMR) in an intact animal model. Accordingly, we developed a model to study serial changes in myocardial metabolism in the intact open-chest rabbit. Ten animals underwent 20 +/- 2 mi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90656-x

    authors: Kavanaugh KM,Aisen AM,Fechner KP,Chenevert TL,Dunham WR,Buda AJ

    更新日期:1989-01-01 00:00:00

  • Mid-cavity obstruction in apical hypertrophy: Doppler evidence of diastolic intraventricular gradient with higher apical pressure.

    abstract::Three cases of apical left ventricular hypertrophy demonstrating a sequestered small left ventricular apical cavity with complete systolic and partial diastolic intraventricular obstruction are described. Doppler studies revealed that flow from the apical chamber is aborted during early systole with further emptying d...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90730-2

    authors: Zoghbi WA,Haichin RN,Quinones MA

    更新日期:1988-12-01 00:00:00

  • Combined vasodilator and inotropic therapy of heart failure: experimental and clinical concepts.

    abstract::Vasodilators facilitate ventricular emptying by affording earlier onset of left ventricular (LV) ejection and increased stroke volume with achievement of a reduced end-systolic pressure and volume. Agents with positive inotropic properties increase stroke volume by shifting the end-systolic pressure-volume curve to th...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(81)90738-9

    authors: Miller RR,Palomo AR,Brandon TA,Hartley CJ,Quinones MA

    更新日期:1981-09-01 00:00:00

  • Prognostic implications of complicated ventricular arrhythmias early after hospital discharge in acute myocardial infarction: a serial ambulatory electrocardiography study.

    abstract::To assess the prevalence and prognostic implications of complicated ventricular ectopic depolarizations (VEDs) after hospital discharge in patients with acute myocardial infarction (AMI), we obtained serial 24-hour Holter recordings in 85 patients during the first 6 weeks after AMI. Recordings were obtained during two...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90745-2

    authors: Olson HG,Lyons KP,Troop P,Butman SM,Piters KM

    更新日期:1984-11-01 00:00:00

  • Age and outcome after acute coronary syndromes without persistent ST-segment elevation.

    abstract:BACKGROUND:Although age is the most important variable associated with death among patients with persistent ST-segment elevation, its impact on outcome among patients without persistent ST-segment elevation remains unknown. Moreover, the impact of age on the efficacy of antiplatelet therapy with eptifibatide is unknown...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(00)90018-8

    authors: Hasdai D,Holmes DR Jr,Criger DA,Topol EJ,Califf RM,Harrington RA

    更新日期:2000-05-01 00:00:00

  • Usefulness of magnetic resonance imaging for evaluating great-vessel anatomy after arterial switch operation for D-transposition of the great arteries.

    abstract::Magnetic resonance imaging (MRI) produces high-resolution images of great-vessel anatomy in pediatric patients. In this study seven patients, aged 6 to 27 months were evaluated by using gated MRI and two-dimensional echocardiography 4 to 26 months after arterial switch operation for D-transposition of the great arteri...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90486-3

    authors: Hardy CE,Helton GJ,Kondo C,Higgins SS,Young NJ,Higgins CB

    更新日期:1994-08-01 00:00:00

  • Does programmed stimulation really help in the evaluation of patients with nonsustained ventricular tachycardia? Results of a meta-analysis.

    abstract::There has been considerable debate regarding the value of programmed electrical stimulation in patients who present with asymptomatic, or minimally symptomatic, nonsustained VT. Unfortunately, there has never been a sufficiently large study of an untreated group of patients to make any sense of the issue. We culled th...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1016/0002-8703(92)90664-h

    authors: Kowey PR,Taylor JE,Marinchak RA,Rials SJ

    更新日期:1992-02-01 00:00:00

  • Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention.

    abstract:BACKGROUND:Peak creatine kinase (CK)-MB concentration is related to reperfusion success and clinical outcomes after fibrinolytic therapy for acute myocardial infarction. However, prognostic implications of CK-MB measurements after primary percutaneous coronary intervention (PCI), which provides more predictable and con...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2014.06.008

    authors: Bagai A,Schulte PJ,Granger CB,Mahaffey KW,Christenson RH,Bell G,Lopes RD,Green CL,Lincoff AM,Armstrong PW,Roe MT

    更新日期:2014-10-01 00:00:00

  • N-terminal pro-brain natriuretic peptide levels and aortic diameters.

    abstract:BACKGROUND:Women with X-chromosome monosomy or Turner syndrome (TS) are at increased risk for aortic dilation and dissection. To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro-brain natriuretic peptide (BNP) (NT-proBNP) levels in women with TS and...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2012.06.021

    authors: Gutin LS,Bakalov VK,Rosing DR,Arai AE,Gharib AM,Bondy CA

    更新日期:2012-09-01 00:00:00

  • Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting.

    abstract::Adventitial heparin delivery has been shown to inhibit thrombosis and neointimal thickening in a rat carotid injury model. To determine whether sustained, local delivery of hirulog, a potent antithrombin agent, inhibits thrombus formation and neointimal thickening after arterial stenting, silicone polymers containing ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90343-9

    authors: Muller DW,Gordon D,Topol EJ,Levy RJ,Golomb G

    更新日期:1996-02-01 00:00:00

  • Effect of direct stenting on clinical outcome in patients treated with percutaneous coronary intervention on saphenous vein graft.

    abstract:BACKGROUND:Percutaneous coronary intervention (PCI) of saphenous vein graft (SVG) is associated with frequent postprocedural enzyme elevation and late cardiac events. New strategies are proposed to minimize distal embolization and to improve the outcome of patients treated with stenting for SVG lesions. The objectives ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/S0002-8703(03)00309-0

    authors: Leborgne L,Cheneau E,Pichard A,Ajani A,Pakala R,Yazdi H,Satler L,Kent K,Suddath WO,Pinnow E,Canos D,Waksman R

    更新日期:2003-09-01 00:00:00

  • Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression.

    abstract:BACKGROUND:The study rationale was to compare the biomarker profile of metalloproteinases (MMPs) and inflammation markers (IMs) in patients requiring revascularization with that of patients with long-term, clinically quiescent coronary artery disease (CAD). METHODS:Seventy-eight patients with symptomatic CAD (S-CAD) (...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.08.021

    authors: Gurbel PA,Kreutz RP,Bliden KP,DiChiara J,Tantry US

    更新日期:2008-01-01 00:00:00

  • The impact of implantable cardioverter defibrillator therapy on health care systems.

    abstract::Implantable cardioverter defibrillators (ICDs) are now widely used for the secondary prevention of sudden cardiac death and are being offered as a primary preventive therapy. This technology has potential for significant fiscal impact on health care budgets. Technologic innovation will result in more complex devices t...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90109-0

    authors: Saksena S

    更新日期:1994-04-01 00:00:00

  • Systolic anterior motion of the mitral chordae tendineae: prevalence and clinical and Doppler-echocardiographic features.

    abstract::The objective of this investigation was to determine the prevalence and clinical associations of systolic anterior motion (SAM) of the mitral chordae (chordal SAM) in patients without evidence of hypertrophic cardiomyopathy. Although SAM of the mitral valve is thought to be a specific marker of hypertrophic obstructiv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90282-3

    authors: Pearson AC,Pasierski TJ,Orsinelli DA,Gray P,Huschart K

    更新日期:1996-04-01 00:00:00

  • Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry.

    abstract:BACKGROUND:Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. METHODS:Using the Get W...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2019.01.006

    authors: Ziaeian B,Hernandez AF,DeVore AD,Wu J,Xu H,Heidenreich PA,Matsouaka RA,Bhatt DL,Yancy CW,Fonarow GC

    更新日期:2019-05-01 00:00:00

  • Impact of beta-blockade on complex cognitive functioning.

    abstract::Fifty adult men with mild to moderate hypertension were recruited to participate in a double-blind crossover study. Each subject received 14 days of drug treatment and 14 days of placebo treatment (random order). Half the subjects were assigned to a metoprolol (150 mg/day) vs placebo treatment regimen and half to an a...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(88)90106-8

    authors: Streufert S,DePadova A,McGlynn T,Pogash R,Piasecki M

    更新日期:1988-07-01 00:00:00

  • Effects of intracoronary streptokinase in acute myocardial infarction.

    abstract::Intracoronary streptokinase (SK) was administered to 11 patients with evolving acute transmural myocardial infarction 5.5 +/- 0.4 hours from the onset of symptoms. Ten patients (91%) had total coronary occlusion, and one had subocclusion of the vessel corresponding to the ECG site of infarction. Intracoronary nitrogly...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(81)90646-3

    authors: Cowley MJ,Hastillo A,Vetrovec GW,Hess ML

    更新日期:1981-12-01 00:00:00

  • Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.

    abstract:BACKGROUND:Bleeding and blood transfusion are associated with increased morbidity and mortality among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, the economic consequences of these complications are not well defined. We sought to determine the relationship between bleeding, bloo...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.10.014

    authors: Rao SV,Kaul PR,Liao L,Armstrong PW,Ohman EM,Granger CB,Califf RM,Harrington RA,Eisenstein EL,Mark DB

    更新日期:2008-02-01 00:00:00

  • Flosequinan: a vasodilator with positive inotropic activity.

    abstract::Flosequinan is an oral arterial and venous vasodilator that is currently under investigation for the treatment of congestive heart failure. The effects of flosequinan on ventricular performance and myocardial contractility were studied in 10 patients with severe congestive heart failure during right and left cardiac c...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90723-u

    authors: Corin WJ,Monrad ES,Strom JA,Giustino S,Sonnenblick ES,LeJemtel T

    更新日期:1991-02-01 00:00:00

  • Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism.

    abstract:BACKGROUND:Plasma levels of brain natriuretic peptide (BNP) are increased in patients with left heart failure. In patients with severe pulmonary embolism (PE), primary right ventricular (RV) dysfunction is frequent. Little is known about BNP secretion in acute RV failure. METHODS:We prospectively studied 50 consecutiv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(03)00528-3

    authors: Krüger S,Graf J,Merx MW,Koch KC,Kunz D,Hanrath P,Janssens U

    更新日期:2004-01-01 00:00:00

  • Posttreatment platelet reactivity on clopidogrel is associated with the risk of adverse events after off-pump coronary artery bypass.

    abstract:BACKGROUND:Dual antiplatelet therapy with aspirin and clopidogrel is currently recommended in off-pump coronary artery bypass (OPCAB). However, no data exist concerning platelet reactivity on clopidogrel after OPCAB. The aim of this study was to assess the relationship between platelet reactivity and late major adverse...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2014.01.016

    authors: Youn YN,Yi G,Lee S,Joo HC,Yoo KJ

    更新日期:2014-06-01 00:00:00

  • Relation between cardiac troponin I and mortality in acute decompensated heart failure.

    abstract:BACKGROUND:Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain. METHODS:In the EFFECT study, we determined the association between cardiac troponin I and all-cause mo...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.01.027

    authors: You JJ,Austin PC,Alter DA,Ko DT,Tu JV

    更新日期:2007-04-01 00:00:00

  • Mixed venous oxygen saturation for differentiating stable from unstable tachycardias.

    abstract::Current antitachycardia systems are incapable of adequately distinguishing stable from unstable tachycardias. Previously, integration of a pressure sensor or an impedance sensor, together with electrogram analysis, has been investigated as an improved method of identifying unstable arrhythmias. A mixed venous oxygen s...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90519-n

    authors: Cohen TJ,Liem LB

    更新日期:1991-09-01 00:00:00

  • Comparative diagnostic value of exercise polarcardiography and 14-lead electrocardiography in the detection of coronary artery disease.

    abstract::Early postexercise polarcardiographic (PCG) changes in the ST segment vector, as reflected in the variable MS X theta, are reported to clearly distinguish normal subjects from those with myocardial ischemia. We prospectively assessed the value of this test in detecting coronary artery disease (CAD) during treadmill ex...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90019-5

    authors: Lam JC,Chaitman BR,Hanson JS,Bernard P,Bourassa MG

    更新日期:1985-12-01 00:00:00