当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Combined vasodilator and inotropic therapy of heart failure: experimental and clinical concepts.

Combined vasodilator and inotropic therapy of heart failure: experimental and clinical concepts.

Abstract：

:Vasodilators facilitate ventricular emptying by affording earlier onset of left ventricular (LV) ejection and increased stroke volume with achievement of a reduced end-systolic pressure and volume. Agents with positive inotropic properties increase stroke volume by shifting the end-systolic pressure-volume curve to the left through augmented force and velocity of contraction. With impedence reduction, improvement in pump performance occurs concomitant with reduced cardiac energy requirements (MVO2); positive inotropic agents most circumstances increase MVO2. The combination of a vasodilator and positive inotropic agent, as opposed to either alone, in the conscious animal shifts to the left and increases the slope of the LV end-systolic pressure-volume relation. Cardiac efficiency, defined by the slope of the relation between stroke volume and systolic tension, is increased by the combination of the drugs. In clinical heart failure, nitroprusside alone lowers LV preload with a modest increase in cardiac output (CO); dopamine markedly increases CO with little fall in LV preload. In combination the two agents achieve the individual beneficial effects of each drug, and cardiac efficiency indices are improved. Thus combined vasodilator and inotropic therapy appears to have a sound physiologic rationale and clinically documented beneficial effect superior to either modality alone.

journal_name

Am Heart J

journal_title

American heart journal

authors

Miller RR,Palomo AR,Brandon TA,Hartley CJ,Quinones MA

doi

10.1016/0002-8703(81)90738-9

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

500-8

issue

3 Pt 2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(81)90738-9

journal_volume

102

pub_type

杂志文章,评审

相关文献

AMERICAN HEART JOURNAL文献大全
  • Transient U wave inversion during variant angina.

    abstract：:We studied the prevalence and clinical significance of transient U wave inversion in 43 patients with variant angina. Twenty-four patients (group A) had ST segment elevation in the anterolateral and 19 patients (group B) had this finding in the inferoposterior leads of the ECG during spontaneous angina. In none of the...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90452-6

    authors： Matsuguchi T,Koiwaya Y,Nakagaki O,Takeshita A,Nakamura M

    更新日期：1984-10-01 00:00:00

  • A double-blind, randomized study of the effect of immediate intravenous nitroglycerin on the incidence of postprocedural chest pain and minor myocardial necrosis after elective coronary stenting.

    abstract：BACKGROUND:Anginal chest pain without creatine kinase (CK) elevation is frequently observed in the first hours after coronary stenting. Possible causes of ischemic episodes are microembolism, side branch occlusion, coronary vasospasm, and disturbances of microvascular circulation. In a prospective, double-blind, random...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(00)90306-5

    authors： Kurz DJ,Naegeli B,Bertel O

    更新日期：2000-01-01 00:00:00

  • The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

    abstract：BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.04.003

    authors： de Groote P,Lamblin N,Helbecque N,Mouquet F,Hermant X,Amouyel P,Dallongeville J,Bauters C

    更新日期：2006-10-01 00:00:00

  • Effect of older age on diagnostic and prognostic performance of high-sensitivity troponin T in patients presenting to an emergency department.

    abstract：BACKGROUND:The effect of age on diagnostic and prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) has not been addressed adequately, so far. METHODS:High-sensitivity cardiac troponin T was measured serially in patients with acute symptoms presenting to our emergency department. We tested the diagn...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.08.003

    authors： Normann J,Mueller M,Biener M,Vafaie M,Katus HA,Giannitsis E

    更新日期：2012-11-01 00:00:00

  • Two-dimensional echocardiographic determination of ventricular septal defect size: correlation with autopsy.

    abstract：:The presence of a large ventricular septal defect (VSD) may affect the surgical treatment of congenital heart defects. VSD size and shape by two-dimensional echocardiography (2DE) and at autopsy were compared in 18 patients, average age 6 months, who had 2DE studies shortly prior to death. Six had isolated VSD and the...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90415-8

    authors： Sharif DS,Huhta JC,Marantz P,Hawkins HK,Yoon GY

    更新日期：1989-06-01 00:00:00

  • Coronary angioplasty in symptomatic patients after bypass surgery.

    abstract：:With the availability of percutaneous transluminal coronary angioplasty (PTCA), the management of patients who present with recurrent angina following coronary artery bypass surgery (CABG) has changed. From January 1987 to December 1988, 149 symptomatic post CABG patients underwent coronary angiography at our institut...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90121-d

    authors： Tabbalat RA,Haft JI

    更新日期：1990-11-01 00:00:00

  • Prognostic value of echocardiographic evaluation of septal function in acute anteroseptal myocardial infarction.

    abstract：:To determine the clinical usefulness of echocardiography in patients with anteroseptal myocardial infarction, echocardiograms were performed within 24 hours of admission on 40 patients with acute transmural anteroseptal myocardial infarction. Twenty-one patients had normal septal motion and septal systolic thickening,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(79)90007-3

    authors： Wiener I,Meller J,Packer M,Herman MV,Teichholz LE

    更新日期：1979-06-01 00:00:00

  • Relation between collateral flow assessed by Doppler guide wire and angiographic collateral grades.

    abstract：:We investigated the relation between the angiographic collateral grade (Rentrop's classification) and the collateral flow velocity pattern in 43 patients with angina pectoris. Collateral flow velocity was measured with a Doppler guide wire during balloon occlusion in coronary angioplasty. Collateral flow was detected ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90232-5

    authors： Yamada T,Okamoto M,Sueda T,Hashimoto M,Kajiyama G

    更新日期：1995-07-01 00:00:00

  • Aggregating traditional cardiovascular disease risk factors to assess the cardiometabolic health of childhood cancer survivors: an analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study.

    abstract：BACKGROUND:Childhood cancer survivors are at increased risk of cardiovascular disease (CVD), which may be associated with traditional CVD risk factors. We used CVD risk aggregation instruments to describe survivor cardiometabolic health and compared their results with sibling controls. METHODS:Traditional CVD risk fac...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2011.11.008

    authors： Landy DC,Miller TL,Lopez-Mitnik G,Lipsitz SR,Hinkle AS,Constine LS,French CA,Rovitelli AM,Adams MJ,Lipshultz SE

    更新日期：2012-02-01 00:00:00

  • Acute myocardial infarction-related coronary artery residual narrowing after intravenous streptokinase: relationship with previous coronary symptoms.

    abstract：:In 72 patients who received streptokinase within 6 hours of the onset of an acute myocardial infarction (AMI), the relationship between the presence of a previous coronary event and the severity of the residual coronary artery stenosis was studied. Fifty-five patients were either asymptomatic or had recent onset angin...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90219-6

    authors： Sarmiento RA,Blüguermann JJ,González Mora RC,Riccitelli MA,Bertolasi CA

    更新日期：1989-11-01 00:00:00

  • The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988.

    abstract：:Digoxin intoxication has been reported to be a common adverse drug reaction with an in-hospital incidence of 6% to 23% and an associated mortality rate as high as 41%. A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hos...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90135-k

    authors： Mahdyoon H,Battilana G,Rosman H,Goldstein S,Gheorghiade M

    更新日期：1990-11-01 00:00:00

  • Beneficial effects of the alpha-adrenergic antagonist nicergoline during acute myocardial ischemia and reperfusion in the dog.

    abstract：:Recent experimental and clinical data have stimulated interest in the use of alpha-adrenergic antagonists in acute myocardial infarction. We evaluated nicergoline, a new relatively selective alpha 1-antagonist which uniquely lowers heart rate. Open-chest dogs, randomized to control (n = 25) or intravenously treated gr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90646-4

    authors： Bolli R,Brandon TA,Fisher DJ,Fernandez GC,Miller RR

    更新日期：1983-11-01 00:00:00

  • Cognitive decline and ischemic microlesions after coronary catheterization. A comparison to coronary artery bypass grafting.

    abstract：BACKGROUND:Postinterventional cognitive dysfunction (PICD) is a known complication of coronary artery bypass grafting (CABG). However, it is largely unknown whether PICD occurs after coronary catheterization. METHODS:Neuropsychologic data were obtained from 37 patients who received coronary catheterization and 47 pati...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2011.07.021

    authors： Schwarz N,Schoenburg M,Möllmann H,Kastaun S,Kaps M,Bachmann G,Sammer G,Hamm C,Walther T,Gerriets T

    更新日期：2011-10-01 00:00:00

  • Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS).

    abstract：:The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in ...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2019.12.020

    authors： Huang L,Tian M,Yu J,Li Q,Liu Y,Yin X,Wu JH,Marklund M,Wu Y,Li N,Elliott P,Yan LL,Labarthe DR,Hao Z,Shi J,Feng X,Zhang J,Zhang Y,Zhang R,Zhou B,Li Z,Sun J,Zhao Y,Yu Y,Neal B

    更新日期：2020-03-01 00:00:00

  • Effects of heart rate on phasic coronary blood flow pattern and flow reserve in patients with normal coronary arteries: a study with an intravascular Doppler catheter and spectral analysis.

    abstract：:To assess the effects of pacing-induced tachycardia on phasic coronary blood flow pattern and flow reserve of left anterior descending artery, we examined 16 patients with chest pain and angiographically normal coronary arteries by using an intravascular Doppler catheter with spectral analysis of the velocity signal. ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90661-0

    authors： Hongo M,Nakatsuka T,Watanabe N,Takenaka H,Tanaka M,Kinoshita O,Okubo S,Sekiguchi M

    更新日期：1994-03-01 00:00:00

  • The choice of arterial access for percutaneous coronary intervention and its impact on outcome: An expert opinion perspective.

    abstract：:The prevention of major bleeding during percutaneous coronary intervention is one of the most widely discussed and often controversial topics within interventional cardiology. The choice of arterial access should be considered a mechanism for bleeding avoidance, and various strategies have been proposed to prevent or ...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2015.04.023

    authors： Baker NC,Ansel GM,Rao SV,Jolly SS,Pichard AD,Steinberg D,Lipinski MJ,Escarcega RO,Minha S,Lhermusier T,Magalhães MA,Waksman R

    更新日期：2015-07-01 00:00:00

  • Clinical and pathologic findings of aortic dissection at autopsy: Review of 336 cases over nearly 6 decades.

    abstract：BACKGROUND:We aimed to characterize the clinical and pathologic findings of aortic dissection (AD) over a nearly 60-year period. METHODS:The Jesse E. Edwards Registry of Cardiovascular Disease database was queried for cardiac specimens from autopsies with AD as a diagnosis and compared 2 cohorts: early (1956-1992) and...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2018.11.006

    authors： Huynh N,Thordsen S,Thomas T,Mackey-Bojack SM,Duncanson ER,Nwuado D,Garberich RF,Harris KM

    更新日期：2019-03-01 00:00:00

  • Rapid, sensitive detection of myoglobulinemia by improved counterimmunoelectrophoresis in cases of acute myocardial infarction.

    abstract：:A counterimmunoelectrophoresis technique for detection of serum myoglobin (Mb) was improved using non-ionic polymer dextran. Precipitin lines were graded according to their strength, which was ascertained by radioimmunoassay data. By this method, serum Mb in concentrations of 500 ng./ml. before stain and of 200 ng./ml...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90084-4

    authors： Hiramori K,Sumiyoshi T,Motegi S,Honda T,Kimata S,Hirosawa K,Kawai H,Kondo A,Iwaasa M,Miyoshi K

    更新日期：1978-08-01 00:00:00

  • Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy.

    abstract：BACKGROUND:Coronary artery disease (CAD) is the most common cause of left ventricular systolic dysfunction (LVSD). Patients with ischemia as the cause of LVSD may warrant revascularization. Angiography is the most accurate method of CAD diagnosis but is invasive, expensive, and associated with some risk. Noninvasive im...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ahj.2010.03.026

    authors： Reynolds HR,Steckman DA,Tunick PA,Kronzon I,Lobach I,Rosenzweig BP

    更新日期：2010-06-01 00:00:00

  • Angiographic methods to assess human coronary angiogenesis.

    abstract：:It is unclear how agents designed to promote angiogenesis in the human heart affect the arteriographic appearance of the collateral circulation. Possible changes in collateral vessels include new collateral vessels arising from epicardial arteries, new branches emanating from existing collateral vessels, wider or long...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-8703(99)70473-4

    authors： Gibson CM,Ryan K,Sparano A,Moynihan JL,Rizzo M,Kelley M,Marble SJ,Laham R,Simons M,McClusky TR,Dodge JT Jr

    更新日期：1999-01-01 00:00:00

  • Long-term efficacy of mexiletine alone and in combination with class Ia antiarrhythmic drugs for refractory ventricular arrhythmias.

    abstract：:The efficacy of mexiletine used alone, and in combination with a class Ia antiarrhythmic drug, was assessed in 159 previously drug-refractory patients with ventricular tachycardia (VT) during serial electrophysiologic studies and during long-term (5-year) clinical follow-up. Electrically-inducible ventricular tachycar...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90482-6

    authors： Whitford EG,McGovern B,Schoenfeld MH,Garan H,Newell JB,McElroy M,Ruskin JN

    更新日期：1988-02-01 00:00:00

  • Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension.

    abstract：BACKGROUND:Circulating mediators, including thromboxane A2, the vasoconstrictor, platelet aggregant, and smooth muscle mitogen, may contribute to the progression of vascular narrowing in primary pulmonary hypertension (PPH). METHODS:To further understand the contribution of thromboxane and to provide novel therapy for...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1067/mhj.2002.121806

    authors： Langleben D,Christman BW,Barst RJ,Dias VC,Galiè N,Higenbottam TW,Kneussl M,Korducki L,Naeije R,Riedel A,Simonneau G,Hirsch AM,Rich S,Robbins IM,Oudiz R,McGoon MD,Badesch DB,Levy RD,Mehta S,Seeger W,Solèr M

    更新日期：2002-05-01 00:00:00

  • Duration of red cell storage before transfusion and in-hospital mortality.

    abstract：BACKGROUND:Red cell transfusions are lifesaving in severely anemic or acutely bleeding patients but may be associated with an increased risk of cardiovascular events in critically ill patients. The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.12.045

    authors： Eikelboom JW,Cook RJ,Liu Y,Heddle NM

    更新日期：2010-05-01 00:00:00

  • Simultaneous invasive and noninvasive evaluations of baroreflex sensitivity with bolus phenylephrine technique.

    abstract：:Estimation of baroreflex sensitivity (BRS) is receiving increasing attention in clinical and experimental cardiology. Until recently, in most studies BRS has been assessed on the basis of invasive blood pressure measurement, which limits its use in large-scale studies and in clinical practice. The development of conti...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(95)90443-3

    authors： Hartikainen JE,Tahvanainen KU,Mäntysaari MJ,Tikkanen PE,Länsimies EA,Airaksinen KE

    更新日期：1995-08-01 00:00:00

  • Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study.

    abstract：OBJECTIVES:To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans. BACKGROUND:African-Americans reportedly have a lower risk of AF than whites despite their higher exposure to AF risk factors. However, precise estimates of AF incidence in Af...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.05.010

    authors： Alonso A,Agarwal SK,Soliman EZ,Ambrose M,Chamberlain AM,Prineas RJ,Folsom AR

    更新日期：2009-07-01 00:00:00

  • Pulmonary valve annulus grows after balloon dilatation of neonatal critical pulmonary valve stenosis.

    abstract：BACKGROUND:Neonates with critical pulmonary valve stenosis often demonstrate small or hypoplastic right ventricular structures. Relief of the obstruction enhances forward flow across the right ventricle and reduces its pressure load. Growth of the right ventricle and especially of the pulmonary valve annulus was evalua...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1053/hj.1998.v136.89576

    authors： Gildein HP,Kleinert S,Goh TH,Wilkinson JL

    更新日期：1998-08-01 00:00:00

  • "Silent" myocardial ischemia during and after exercise testing in patients with coronary artery disease.

    abstract：:Although many patients with coronary artery disease (CAD) have a positive exercise test without pain, the frequency and significance of this "silent" ischemia is unclear. Therefore, we studied 122 consecutive clinically stable patients with angiographically defined CAD (greater than 75 per cent luminal stenosis) and a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90234-x

    authors： Lindsey HE Jr,Cohn PF

    更新日期：1978-04-01 00:00:00

  • Changes in glycoprotein IIb/IIIa inhibitor excess dosing with site-specific safety feedback in the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) initiative

    abstract：BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors can improve outcomes in patients with non-ST-segment elevation acute coronary syndromes but raise the risk of bleeding, particularly if dosed in excess. The impact of GP IIb/IIIa dosing feedback on safety and major bleeding is unknown. METHODS:Glycoprotein IIb/IIIa dosi...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2010.08.008

    authors： Mudrick DW,Chen AY,Roe MT,Newby LK,Gibler WB,Ohman EM,Peterson ED,Alexander KP

    更新日期：2010-12-01 00:00:00

  • Heart failure disease management in an indigent population.

    abstract：BACKGROUND:Multidisciplinary disease management programs (MDMP) have demonstrated reduced hospitalizations in motivated pretransplant heart failure populations, but little is known about their effectiveness in largely indigent patients who are not transplant candidates. METHODS AND RESULTS:We studied 35 patients with ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.111956

    authors： O'Connell AM,Crawford MH,Abrams J

    更新日期：2001-02-01 00:00:00

  • Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial.

    abstract：OBJECTIVES:SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure. METHODS AND RESULTS:The study was designed as a 2-armed partially blinded parallel...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2018.09.007

    authors： SUPPORT-HF 2 Investigators and Committees. Electronic address: kazem.rahimi@georgeinstitute.ox.ac.uk.

    更新日期：2019-02-01 00:00:00