当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Effects of heart rate on phasic coronary blood flow pattern and flow reserve in patients with normal coronary arteries: a study with an intravascular Doppler catheter and spectral analysis.

Effects of heart rate on phasic coronary blood flow pattern and flow reserve in patients with normal coronary arteries: a study with an intravascular Doppler catheter and spectral analysis.

Abstract：

:To assess the effects of pacing-induced tachycardia on phasic coronary blood flow pattern and flow reserve of left anterior descending artery, we examined 16 patients with chest pain and angiographically normal coronary arteries by using an intravascular Doppler catheter with spectral analysis of the velocity signal. The heart rate was increased from a mean of 68 +/- 11 beats/min during sinus rhythm to 100 beats/min and again to 120 beats/min. Cross-sectional area of the epicardial artery and resting systolic and diastolic coronary blood flows increased progressively, resulting in an elevation of total coronary flow from 142 +/- 54 ml/min during sinus rhythm to 190 +/- 66 ml/min at 100 beats/min (p < 0.05) and to 219 +/- 69 ml/min at 120 beats/min (p < 0.01). During maximal hyperemia with intracoronary injection of 10 to 12 mg of papaverine, there was an increase in the systolic coronary blood flow with a decrease in the diastolic flow, resulting in no significant change in the total flow. These alterations led to progressive reductions in coronary flow reserve from 3.9 +/- 0.7 during sinus rhythm to 2.9 +/- 0.9 at 100 beats/min (p < 0.01) and to 2.3 +/- 0.3 at 120 beats/min (p < 0.001). Thus careful consideration should be given to the effects of heart rate when phasic coronary blood flow pattern and flow reserve are assessed.

journal_name

Am Heart J

journal_title

American heart journal

authors

Hongo M,Nakatsuka T,Watanabe N,Takenaka H,Tanaka M,Kinoshita O,Okubo S,Sekiguchi M

doi

10.1016/0002-8703(94)90661-0

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

545-51

issue

3

eissn

0002-8703

issn

1097-6744

pii

0002-8703(94)90661-0

journal_volume

127

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • The influence of risk status on guideline adherence for patients with non-ST-segment elevation acute coronary syndromes.

    abstract：BACKGROUND:Practice guidelines for patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) recommend targeting evidence-based therapies for the highest-risk patients. We characterized guideline adherence for NSTE ACS by risk status. METHODS:We analyzed inhospital treatments and outcomes for 77760 ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.08.006

    authors： Roe MT,Peterson ED,Newby LK,Chen AY,Pollack CV Jr,Brindis RG,Harrington RA,Christenson RH,Smith SC Jr,Califf RM,Braunwald E,Gibler WB,Ohman EM

    更新日期：2006-06-01 00:00:00

  • Hemodynamic response patterns to mental stress: diagnostic and therapeutic implications.

    abstract：:Stress has been identified as contributing to the development of cardiovascular disease. The pathophysiologic link between stress and disease still remains unclear. Because experimental stress testing in the laboratory permits the examination of the underlying mechanism for stress-induced blood pressure, analyses of c...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90560-1

    authors： Rüddel H,Langewitz W,Schächinger H,Schmieder R,Schulte W

    更新日期：1988-08-01 00:00:00

  • Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents.

    abstract：BACKGROUND:Whether low-molecular-weight heparin (LMWH) is superior to unfractionated heparin (UFH) in acute ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) remains unclear. METHODS:A total of 3,372 STEMI patients wh...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ahj.2009.12.041

    authors： Li YJ,Rha SW,Chen KY,Poddar KL,Jin Z,Minami Y,Wang L,Dang Q,Li GP,Ramasamy S,Park JY,Choi CU,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ,Jeong MH,Ahn YK,Hong TJ,Park JS,Kim YJ,Hur SH,Seong IW,Chae JK,Cho MC,Bae

    更新日期：2010-04-01 00:00:00

  • Outcomes after STEMI in old multimorbid patients with complex health needs and the effect of invasive management.

    abstract：BACKGROUND:The aim of this study was to assess one-year outcomes of invasive and non-invasive strategies in ST-elevation myocardial infarction (STEMI) among multimorbid older people with complex health needs. METHODS:We included patients, registered between 2006 and 2013 in the SWEDEHEART registry, who were 70 years o...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2019.01.008

    authors： Gudnadottir GS,James SK,Andersen K,Lagerqvist B,Thrainsdottir IS,Ravn-Fischer A,Varenhorst C,Gudnason T

    更新日期：2019-05-01 00:00:00

  • A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

    abstract：BACKGROUND:The aim of this study was to compare rate of onset, magnitude, and consistency of platelet inhibition after administration of prasugrel or clopidogrel and to relate platelet inhibition to systemic exposure to each active metabolite. Thienopyridines are prodrugs, metabolized in vivo to active metabolites that...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2006.10.010

    authors： Brandt JT,Payne CD,Wiviott SD,Weerakkody G,Farid NA,Small DS,Jakubowski JA,Naganuma H,Winters KJ

    更新日期：2007-01-01 00:00:00

  • Drug interactions with amiodarone.

    abstract：:There are a number of important drug interactions with amiodarone. This agent appears to have a marked effect on the kinetics of some commonly used cardiovascular drugs, such as warfarin, digoxin, quinidine, and procainamide, and has dynamic interactions with others, such as the beta blockers and some calcium antagoni...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90017-0

    authors： Marcus FI

    更新日期：1983-10-01 00:00:00

  • Induction of neointimal hyperplasia by coronary angioplasty balloon overinflation: comparison of feeder pigs to Yucatan minipigs.

    abstract：:We evaluated the use of simple balloon overinflation to induce neointimal hyperplasia in a porcine model of coronary artery restenosis. By using standard percutaneous transluminal coronary angioplasty techniques, left anterior descending (LAD) and/or left circumflex (LCX) coronary arteries of either juvenile feeder pi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90505-3

    authors： Humphrey WR,Simmons CA,Toombs CF,Shebuski RJ

    更新日期：1994-01-01 00:00:00

  • Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study.

    abstract：BACKGROUND:According to a recent meta-analysis, parathyroid hormone (PTH) excess is associated with increased cardiovascular disease (CVD) risk, but existing studies are limited. We examined in a prospective study the association of PTH with the incidence of CVD, taking into account vitamin D and other confounding vari...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2014.04.017

    authors： Folsom AR,Alonso A,Misialek JR,Michos ED,Selvin E,Eckfeldt JH,Coresh J,Pankow JS,Lutsey PL

    更新日期：2014-09-01 00:00:00

  • New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft.

    abstract：BACKGROUND:New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. METHODS:Among ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2013.12.010

    authors： Lee SH,Kang DR,Uhm JS,Shim J,Sung JH,Kim JY,Pak HN,Lee MH,Joung B

    更新日期：2014-04-01 00:00:00

  • Precordial ST-segment mapping 3. Stability of maps in the early phase of acute myocardial infarction.

    abstract：:To evaluate the stability of precordial ST-segment mapping techniques in assessing ischemic myocardial injury, we studied 28 patients with acute anterior myocardial infarction using a 49-lead electrocardiographic system (1 mV. = 10 mm.). The sum of ST elevations in millimeters was taken as an index of ischemic injury,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(77)80011-2

    authors： Madias JE,Hood WB Jr

    更新日期：1977-05-01 00:00:00

  • Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.

    abstract：:The effects of lorcainide, a new antiarrhythmic drug, on serum electrolytes and osmolality are described in a series of 33 patients with organic heart disease and complex ventricular arrhythmias treated with lorcainide. In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 2...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90690-2

    authors： Somani P,Temesy-Armos PN,Leighton RF,Goodenday LS,Fraker TD Jr

    更新日期：1984-12-01 00:00:00

  • Response of the left ventricle in idiopathic dilated cardiomyopathy to postextrasystolic potentiation.

    abstract：:The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90661-2

    authors： Yamazoe M

    更新日期：1987-06-01 00:00:00

  • Estimation of regional end-systolic wall stress during exercise in coronary artery disease.

    abstract：:Estimating left ventricular wall stress has recognized applications, but formulae for global stress cannot be applied to ischemic ventricles. A mathematic method for estimating regional stress in infarcted ventricles has been described. The hypothesis tested was that exercise-induced ischemia increases end-systolic wa...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90305-1

    authors： Ginzton LE,Rodrigues D,Shapiro SM,Laks MM,Conant R,Lobodzinski SM

    更新日期：1996-10-01 00:00:00

  • Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE).

    abstract：BACKGROUND:Research has shown that vaccination with Streptococcus pneumoniae reduced the extent of atherosclerosis in experimental animal models. It is thought that phosphorylcholine lipid antigens in the S. pneumoniae cell wall induce the production of antibodies that cross-react with oxidized low-density lipoprotein,...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2016.04.003

    authors： Ren S,Hure A,Peel R,D'Este C,Abhayaratna W,Tonkin A,Hopper I,Thrift AG,Levi C,Sturm J,Durrheim D,Hung J,Briffa T,Chew DP,Anderson P,Moon L,McEvoy M,Hansbro P,Newby D,Attia J,AUSPICE study group.

    更新日期：2016-07-01 00:00:00

  • Successful left ventricular opacification following peripheral venous injection of sonicated contrast agent: an experimental evaluation.

    abstract：:A new agent for use in contrast echocardiography that is capable of passing through the pulmonary circulation and opacifying the left ventricular cavity after intravenous injection was evaluated in a canine model. Air-filled albumin microbubbles were produced by sonication. A Coulter counter was used to size and count...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90754-x

    authors： Keller MW,Feinstein SB,Watson DD

    更新日期：1987-09-01 00:00:00

  • Percutaneous coronary mid-infra-red laser angioplasty.

    abstract：:A pilot study was performed to determine the safety and efficacy of coronary pulsed mid-infra-red laser angioplasty. The laser was coupled with a novel 2.0 mm multifiber catheter consisting of 37 optical fibers of 150 microns each arranged concentrically around a 0.018-inch central lumen and a soft leading tapered dis...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)91015-f

    authors： Geschwind HJ,Dubois-Rande JL,Zelinsky R,Morelle JF,Boussignac G

    更新日期：1991-08-01 00:00:00

  • Effect of discontinuance of type A behavioral counseling on type A behavior and cardiac recurrence rate of post myocardial infarction patients.

    abstract：:Three hundred post infarction participants who had received type A behavioral counseling in the Recurrent Coronary Prevention Project, (RCPP) agreed to be followed for 1 additional year after stopping 4.5 years of continuous type A behavioral counseling. One hundred fourteen participants who had served for 4.5 years a...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(87)90742-3

    authors： Friedman M,Powell LH,Thoresen CE,Ulmer D,Price V,Gill JJ,Thompson L,Rabin DD,Brown B,Breall WS

    更新日期：1987-09-01 00:00:00

  • Factors associated with development of atrial septal restriction in patients with tricuspid atresia involving the right-sided atrioventricular valve.

    abstract：BACKGROUND:Clinical practice is discrepant regarding routine enlargement of the interatrial communication (IAC) in patients with right-sided atrioventricular valve atresia. We determined the percentage and risk factors of those who develop a restrictive IAC. METHODS:Medical records were reviewed for patients treated f...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.07.037

    authors： Tzifa A,Gauvreau K,Geggel RL

    更新日期：2007-12-01 00:00:00

  • Acute and chronic effects of amiodarone on delayed afterdepolarization and triggered automaticity in rabbit ventricular myocardium.

    abstract：:The effects of amiodarone on delayed afterdepolarization (DAD) and triggered automaticity induced by low potassium (0.5 mEq/L) were evaluated on isolated rabbit right ventricular muscles, by means of standard microelectrode techniques. Triggered automaticity was induced in 6 of 10 muscles in the control group, in four...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90267-5

    authors： Ohta M,Karagueuzian HS,Mandel WJ,Peter T

    更新日期：1987-02-01 00:00:00

  • Immediate and late outcome of patients aged 80 years and older undergoing isolated aortic valve replacement: a systematic review and meta-analysis of 48 studies.

    abstract：OBJECTIVE:This study was planned to evaluate the outcome of patients ≥80 years old undergoing isolated conventional aortic valve replacement (AVR). METHODS:Systematic review of the literature and meta-analysis of data on octogenarians and nonagenarians who underwent isolated AVR were performed. RESULTS:The literature...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ahj.2011.12.005

    authors： Vasques F,Messori A,Lucenteforte E,Biancari F

    更新日期：2012-03-01 00:00:00

  • Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention.

    abstract：BACKGROUND:In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce t...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2016.07.001

    authors： deFilippi CR,de Lemos JA,Newman AB,Guralnik JM,Christenson RH,Pahor M,Church T,Espeland M,Krithevsky SB,Stafford R,Seliger SL,LIFE Study Group.

    更新日期：2016-09-01 00:00:00

  • Efficacy of intravenous amiodarone as short-term treatment for refractory ventricular tachycardia.

    abstract：:The antiarrhythmic efficacy and safety of intravenous amiodarone were evaluated in 13 patients with recurrent sustained ventricular tachycardia. All patients had been refractory to at least three prior antiarrhythmic agents (mean, 3.3 per patient), and 11 had multiple direct current cardioversions. Intravenous amiodar...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90523-6

    authors： Klein RC,Machell C,Rushforth N,Standefur J

    更新日期：1988-01-01 00:00:00

  • Outpatient dobutamine and dopamine infusions in the management of chronic heart failure: clinical experience in 21 patients.

    abstract：:Dobutamine (and dopamine) are potent positive inotropic drugs which are frequently given to treat decompensated congestive heart failure. This study reports on the use of ambulatory dobutamine (and dopamine) infusions in 21 outpatients with advanced congestive heart failure. Each patient was initially hospitalized, an...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90757-5

    authors： Applefeld MM,Newman KA,Sutton FJ,Reed WP,Roffman DS,Talesnick BS,Grove WR

    更新日期：1987-09-01 00:00:00

  • Effects of coronary artery bypass surgery and angioplasty on the total ischemic burden: a study of exercise testing and ambulatory ST segment monitoring.

    abstract：:To assess the effects of standard therapeutic interventions on the total ischemic burden, 86 patients with stable angina underwent 48 hours of ambulatory ST segment monitoring and treadmill exercise testing before and at a mean of 10 weeks after coronary artery bypass surgery (CABG) (group 1, N = 46) or percutaneous t...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90495-h

    authors： Mulcahy D,Keegan J,Phadke K,Wright C,Sparrow J,Purcell H,Fox K

    更新日期：1992-03-01 00:00:00

  • Design of the RELAXin in acute heart failure study.

    abstract：BACKGROUND:Acute heart failure (AHF) remains a major public health burden with a high prevalence and poor prognosis. Relaxin is a naturally occurring peptide hormone that increases cardiac output, arterial compliance, and renal blood flow during pregnancy. The RELAX-AHF-1 study will evaluate the effect of RLX030 (recom...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2011.10.009

    authors： Ponikowski P,Metra M,Teerlink JR,Unemori E,Felker GM,Voors AA,Filippatos G,Greenberg B,Teichman SL,Severin T,Mueller-Velten G,Cotter G,Davison BA

    更新日期：2012-02-01 00:00:00

  • Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model.

    abstract：:This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90081-0

    authors： Haas GJ,McCune SA,Brown DM,Cody RJ

    更新日期：1995-10-01 00:00:00

  • The safety and efficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX) trial.

    abstract：BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2016.12.004

    authors： Gibson CM,Halaby R,Korjian S,Daaboul Y,Arbetter DF,Yee MK,Goldhaber SZ,Hull R,Hernandez AF,Lu SP,Bandman O,Leeds JM,Gold A,Harrington RA,Cohen AT,APEX Investigators.

    更新日期：2017-03-01 00:00:00

  • Paradoxical embolism: clinical presentation, diagnostic strategies, and therapeutic options.

    abstract：:Thirty cases of paradoxical embolism are reviewed to consolidate clinical presentations and common predisposing factors. The presence of patent foramen ovale in the great majority of these patients in association with maneuvers that transiently elevate right atrial pressure is emphasized in relation to the pathophysio...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(86)90692-7

    authors： Loscalzo J

    更新日期：1986-07-01 00:00:00

  • The influence of exercise training on the ventilatory threshold of patients with coronary heart disease.

    abstract：:Out of 156 patients with stable coronary heart disease randomized to either an exercise intervention group or a control group, 41 had complete gas analysis data. Continuous gas exchange data, including the ventilatory threshold, and selected heart rates were determined initially and at 1 year. The mean attendance for ...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(85)90548-4

    authors： Sullivan M,Ahnve S,Froelicher VF,Meyers J

    更新日期：1985-03-01 00:00:00

  • Clinical comparison of "normal-hours" vs "off-hours" percutaneous coronary interventions for ST-elevation myocardial infarction.

    abstract：BACKGROUND:High mortality rates were reported in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary interventions (PPCI) "off-hours." The objective of this study was to evaluate this issue in a more recent population of patients with STEMI treated with PPCI in a high-volume ter...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.04.025

    authors： Ortolani P,Marzocchi A,Marrozzini C,Palmerini T,Saia F,Aquilina M,Baldazzi F,Silenzi S,Taglieri N,Grosseto D,Bacchi-Reggiani ML,Guastaroba P,Grilli R,Branzi A

    更新日期：2007-08-01 00:00:00