Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model.

Abstract:

:This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) were compared. Wistar-Kyoto and Sprague-Dawley strains served as the normotensive control group. SHHF rats had significantly greater left ventricular mass than did rats in the normotensive control group. Although left ventricular mass was not different between SHHF and SHR, significant differences were seen in the pattern of left ventricular remodeling as determined by relative wall thickness. These differences in left ventricular remodeling may explain the earlier development of heart failure in SHHF. The different patterns of left ventricular hypertrophy in SHHF and SHR suggests that heart failure in SHHF is not mediated by hypertension alone.

journal_name

Am Heart J

journal_title

American heart journal

authors

Haas GJ,McCune SA,Brown DM,Cody RJ

doi

10.1016/0002-8703(95)90081-0

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

806-11

issue

4

eissn

0002-8703

issn

1097-6744

pii

0002-8703(95)90081-0

journal_volume

130

pub_type

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