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Incidence and natural history of coronary artery aneurysm developing after drug-eluting stent implantation.

Abstract：

AIMS:There is a growing concern about the occurrence of coronary artery aneurysms (CAAs) after drug-eluting stent (DES) implantation and their long-term course. We assessed the occurrence and the factors affecting the long-term outcome of DES-associated CAA. METHODS AND RESULTS:We analyzed 3,612 consecutive patients (4,419 lesions) who underwent follow-up angiography after DES implantation. All 34 CAAs (0.76% per lesion) in 29 patients (0.8% per patient) were detected at follow-up, and the mean elapsed time from DES implantation to CAA diagnosis was 414 ± 213 days. Angiographically, CAAs developed almost exclusively in complex (type B2/C) de novo lesions (30 [88.2%] of 34 lesions), and lesion length was significantly greater in patients with CAA than without CAA (26.9 ± 9.03 vs 23.1 ± 7.14 mm; P = .004). Myocardial infarction with stent thrombosis occurred in 5 patients with CAA (17.2%), 4 of whom were on aspirin only without clopidogrel. CONCLUSION:Although CAAs rarely develop after DES implantation and show mostly favorable clinical courses, long-term maintenance of clopidogrel therapy might be required to minimize occurrence of adverse clinical events resulting from stent thrombosis.

journal_name

Am Heart J

journal_title

American heart journal

authors

Ahn CM,Hong BK,Kim JY,Min PK,Yoon YW,Lee BK,Kwon HM,Kim JS,Ko YG,Choi D,Hong MK,Jang Y,Shim WH,Cho SY,Kim BK,Oh S,Jeon DW,Yang JY,Jung JH

doi

10.1016/j.ahj.2010.07.013

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

987-94

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00652-6

journal_volume

160

pub_type

杂志文章,多中心研究

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