Abstract:
:Patients with syndrome X have been found to have an abnormal coronary blood flow reserve. The physical performance during exercise, however, has been incompletely investigated. Cardiopulmonary exercise testing (CPX) is a reliable noninvasive method to provide indexes of lung, heart, circulation, and muscle functions. In 15 patients (10 women) with syndrome X and in age and sex-matched normal individuals, CPX was performed twice a day (8 AM and 4 PM) on two separate occasions 2 months apart. Time and oxygen consumption at peak exercise, at ventilatory anaerobic and electrocardiographic thresholds, as well as norepinephrine plasma concentrations at each work load and at peak exercise in both tests were obtained. In syndrome X in both evaluations, the 4 PM performance was characterized by an earlier onset of both ventilatory anaerobic and electrocardiographic thresholds despite lower values of VO2 and double-product, and by a greater peak ST segment depression despite similar total exercise time, VO2, and double-product. No difference between tests was found in the norepinephrine response to exercise. Normal subjects showed reproducible CPX and hormonal responses in the two tests. Thus these data may suggest a circadian variation of coronary vascular response to exercise in patients with syndrome X, leading to a lower ischemic threshold early in the afternoon. The parallel earlier onset of the ventilatory anaerobic threshold may reflect a concomitant abnormal muscular blood flow response (that is, vasoconstriction of working muscle arteries), suggesting a link between coronary and peripheral circulations.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Montorsi P,Agostoni PG,Annoni L,Vincenzi P,Guazzi MDdoi
10.1016/0002-8703(93)90162-3subject
Has Abstractpub_date
1993-03-01 00:00:00pages
711-7issue
3eissn
0002-8703issn
1097-6744pii
0002-8703(93)90162-3journal_volume
125pub_type
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pub_type: 杂志文章,随机对照试验
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更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-07-01 00:00:00