Abstract:
:Studies on cardiac conduction disorders and pacemaker tachycardias are usually conducted in patients because the phenomenon of ventriculoatrial (retrograde) conduction resulting from ectopic beats and pacing the ventricles has only been reported in humans. This study was conducted to characterize the ventriculoatrial (VA) conduction and retrograde P wave electrogram (EGM) amplitude and slew rate in 10 anesthetized pigs. Three transvenous pacemaker leads were positioned in the heart: one in the right atrial appendage, one in the sinoatrial (SA) node region, and another in the apex of the right ventricle. Ventriculoatrial conduction always occurred when the heart was paced from the right ventricle. There was a significant difference (p less than 0.05) between the amplitude and slew rate of the intrinsic P wave EGM (6.36 +/- 1.88 mV, 1.03 +/- 0.35 mV/msec) compared to the retrograde P wave EGM (3.12 +/- 1.37 mV, 0.57 +/- 0.18 mV/msec) detected at the SA node region. However, there was no significant difference between the intrinsic P wave EGM (4.81 +/- 2.01 mV, 0.40 +/- 0.26 mV/msec) and the retrograde P wave EGM (4.13 +/- 3.74 mV, 0.13 +/- 0.05 mV/msec) detected in the atrial appendage. The advantage of positioning an electrode in close proximity to the SA node for optimum atrial EGM detection and differentiation from retrograde P wave EGM is evident. The VA conduction time (178.5 +/- 8.5 msec) was significantly greater (p less than 0.01) than the antegrade conduction time (120.0 +/- 18.2 msec). The pig with its VA conduction is a useful model for pacemaker-induced tachycardias and for in vivo testing of drugs and/or pacemaker programs that can be utilized for controlling or preventing them.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Bowman TA,Hughes HCdoi
10.1016/0002-8703(84)90621-5subject
Has Abstractpub_date
1984-08-01 00:00:00pages
337-41issue
2eissn
0002-8703issn
1097-6744pii
0002-8703(84)90621-5journal_volume
108pub_type
杂志文章abstract:BACKGROUND:The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study showed that cholesterol-lowering therapy prevented further events in patients with coronary heart disease and average cholesterol levels. The aim of this subgroup analysis was to assess the effects of pravastatin in women. METHOD...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,meta分析
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更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:The ODYSSEY COMBO I study (http://clinicaltrials.gov/show/NCT01644175) evaluated efficacy and safety of alirocumab as add-on therapy to stable maximally tolerated daily statin with or without other lipid-lowering therapy in high cardiovascular risk patients with suboptimally controlled hypercholesterolemia. ...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-06-01 00:00:00
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doi:10.1016/0002-8703(86)90153-5
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Most analyses of complications after percutaneous coronary intervention have been limited to angiographic predictors of abrupt closure. We sought to determine the relation between baseline clinical and angiographic characteristics and clinical ischemic events and whether treatment with the platelet glycoprot...
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.04.018
更新日期:2006-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.06.020
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/s0002-8703(98)70004-3
更新日期:1998-10-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.12.009
更新日期:2014-04-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,收录出版
doi:10.1016/0002-8703(84)90421-6
更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(88)90482-6
更新日期:1988-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(77)80170-1
更新日期:1977-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2007.03.024
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0002-8703(81)80006-3
更新日期:1981-08-01 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-10-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:1983-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ahj.2008.04.009
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ahj.2017.11.007
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ahj.2018.01.003
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究
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更新日期:2013-10-01 00:00:00